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Kortüm, Klaus M

Mayo Clinic

Division of Hematology - Oncology, Mayo Clinic, Scottsdale, AZ, USA.

Citations 1

Targeted sequencing using a 47 gene multiple myeloma mutation panel (M3P) in ‐17p high risk disease
Langer, Christian , Monge, Jorge , Bruins, Laura A., Egan, Jan B. , Zhu, Yuan Xiao , Jedlowski, Patrick , Schmidt, Jessica, Ojha, Juhi, Bullinger, Lars , Liebisch, Peter, Kull, Miriam, Champion, Mia D., Wier, Scott Van, Ahmann, Gregory , Rasche, Leo , Knop, Stefan , Stewart, A. Keith, Braggio, Esteban , Kortüm, Klaus M, Kortüm, K. Martin , Chang, Shi , Fonseca, Rafaël , Einsele, Hermann , Braggio, Esteban

British Journal of Haematology | October 10, 2014 | Volume: 168 | Issue: 4 | Pages: 507-510

10.1111/bjh.13171 Get It

SummaryWe constructed a multiple myeloma (MM)‐specific gene panel for targeted sequencing and investigated 72 untreated high‐risk (del17p) MM patients. Mutations were identified in 78% of the patients. While the majority of studied genes were mutated at similar frequency to published literature, the prevalence of TP53 mutation was increased (28%) and no mutations were found in FAM46C. This study provides a comprehensive insight into the mutational landscape of del17p high‐risk MM. Additionally, our work demonstrates the practical use of a customized sequencing panel, as an easy, cheap and fast approach to characterize the mutational profile of MM.