Citations 1
Targeted sequencing of refractory myeloma reveals a high incidence of mutations in CRBN and Ras pathway genes
Mai, Elias K., Hanafiah, Nur Hafzan Md , Shi, Chang-Xi, Zhu, Yuan-Xiao, Bruins, Laura A., Barrio, Santiago , Jedlowski, Patrick , Merz, Maximilian , Xu, Jing , Andrulis, Mindaugas , Jauch, Anna , Hillengaß, Jens , Goldschmidt, Hartmut , Bergsagel, P. Leif , Braggio, Esteban , Stewart, A. Keith, Bergsagel, P. Leif , Bruins, Laura, Stewart, Robert A, Raab, Marc S , Kortüm, K. Martin , Mai, Elias K., Stewart, Robert A., Raab, Marc S. , Braggio, Esteban , Merz, Maximilian
Blood | July 25, 2016 | Volume: 128 | Issue: 9 | Pages: 1226-1233
Key Points The incidence of mutations within the MAPK pathway, the CRBN pathway, and TP53 is significantly increased in drug-refractory MM. Mutations in CRBN might contribute to IMiD resistance in drug-refractory MM.