Citations 5
Pathologic Validation of the EADC-ADNI Harmonized Hippocampal Protocol (P6.331)
Apostolova, Liana G. , Zarow, Chris, Biado, Kristina, Babakchanian, Sona, Honarpisheh, Hedieh, Blanken, Anna E., Brook, Jenny , Tung, Spencer, Ng, Denise , Alger, Jeffrey, Vinters, Harry V. , Duvernoy, Henri M., Boccardi, Marina , Somme, Johanne Hatteland , Bocchetta, Martina , Jack, Clifford R. , Frisoni, Giovanni B.
Neurology | December 7, 2023 | Volume: 82 | Issue: 10_supplement | Pages: No page available
Relationship between hippocampal atrophy and neuropathology markers: A 7T MRI validation study of the EADC‐ADNI Harmonized Hippocampal Segmentation Protocol
Apostolova, Liana G. , Zarow, Chris, Biado, Kristina, Hurtz, Sona, Boccardi, Marina , Honarpisheh, Hedieh, Blanken, Anna E., Brook, Jenny , Tung, Spencer, Kraft, Emily, Lo, D.C.W. , Ng, Denise , Alger, Jeffry R. , Vinters, Harry V. , Bocchetta, Martina , Duvernoy, Henri M., Jack, Clifford R. , Frisoni, Giovanni B. , Segmentation, EADC‐ADNI Working Group on the Harmonized Protocol for Manual Hippocampal, Bartzokis, George, Csernansky, John G., deToledo‐Morrell, Leyla, Lehéricy, Stéphane , Malykhin, Nikolai , Pantel, Johannes, Pruessner, Jens C. , Watson, Craig, Boccardi, Marina , Frisoni, Giovanni B. , Somme, Johanne Hatteland , Segmentation, EADC‐ADNI Working Group on the Harmonized Protocol for Manual Hippocampal, Leon, Mony J. de , Killiany, Ronald , Soininen, Hilkka S. , Jack, Clifford R , Bocchetta, Martina
Alzheimer's & Dementia | January 22, 2015 | Volume: 11 | Issue: 2 | Pages: 139-150
AbstractObjectiveThe pathologic validation of European Alzheimer's Disease Consortium Alzheimer’s Disease Neuroimaging Initiative Center Harmonized Hippocampal Segmentation Protocol (HarP).MethodsTemporal lobes of nine Alzheimer's disease (AD) and seven cognitively normal subjects were scanned post‐mortem at 7 Tesla. Hippocampal volumes were obtained with HarP. Six‐micrometer‐thick hippocampal slices were stained for amyloid beta (Aβ), tau, and cresyl violet. Hippocampal subfields were manually traced. Neuronal counts, Aβ, and tau burden for each hippocampal subfield were obtained.ResultsWe found significant correlations between hippocampal volume and Braak and Braak staging (ρ = −0.75, P = .001), tau (ρ = −0.53, P = .034), Aβ burden (ρ = −0.61, P = .012), and neuronal count (ρ = 0.77, P < .001). Exploratory subfield‐wise significant associations were found for Aβ in Cornu Ammonis (CA)1 (ρ = −0.58, P = .019) and subiculum (ρ = −0.75, P = .001), tau in CA2 (ρ = −0.59, P = .016), and CA3 (ρ = −0.5, P = .047), and neuronal count in CA1 (ρ = 0.55, P = .028), CA3 (ρ = 0.65, P = .006), and CA4 (ρ = 0.76, P = .001).ConclusionsThe observed associations provide pathological confirmation of hippocampal morphometry as a valid biomarker for AD and pathologic validation of HarP.
The EADC‐ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity
Frisoni, Giovanni B. , Jack, Clifford R. , Bocchetta, Martina , Frederiksen, Kristian Steen , Liu, Yawu , Preboske, Gregory M., Swihart, Tim, Blair, Melanie , Cavedo, Enrica , Grothe, Michel J. , Lanfredi, Mariangela , Martinez, Oliver, Nishikawa, Masami, Portegies, Marileen, Stoub, Travis , Ward, Chadwich, Apostolova, Liana G. , Ganzola, Rossana , Barkhof, Frederik , Bartzokis, George, DeCarli, Charles , Csernansky, John G., deToledo‐Morrell, Leyla, Geerlings, Mirjam I. , Lehéricy, Stéphane , O’Brien, John T. , Silbert, Lisa C. , Scheltens, Philip , Waldemar, Gunhild, Fellgiebel, Andreas , Barnes, Josephine , Gerritsen, Lotte , Henneman, Wouter J.P., Malykhin, Nikolai , Pruessner, Jens C. , Watson, Craig, Leon, Mony J. de , Pantel, Johannes, Ferrari, Clarissa , Bosco, Paolo , Pasqualetti, Patrizio , Duchesne, Simon , Duvernoy, Henri M., Boccardi, Marina , Initiative, EADC‐ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging, Albert, Marilyn S. , Bennet, David, Camicioli, Richard , Collins, D. Louis , Dubois, Bruno , Hampel, Harald , denHeijer, Tom, Hock, Christofer, Jagust, William J. , Launer, Leonore J., Maller, Jerome J. , Mueller, S. G., Sachdev, Perminder S. , Simmons, Andy, Visser, Peter‐Jelle, Wahlund, Lars‐Olof , Weiner, Michael W. , Winblad, Bengt , Boccardi, Marina , Frisoni, Giovanni B. , DeCarli, Charles , Preboske, Gregory, Bauer, Corinna M. , Wolf, Dominik Georg Friedrich , Kaye, Jeffrey , Killiany, Ronald , Matsuda, Hiroshi , O'Brien, John Tiernan , Soininen, Hilkka S. , Teipel, Stefan Johannes , Waldemar, Gunhild , Firbank, Michael John , Wang, Lei , Wolf, Henrike , Initiative, EADC‐ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging, Thompson, Paul M. , Jack, Clifford R , Sachdev, Perminder S , Barkhof, Frederik , Scheltens, Philip , Wahlund, Lars-Olof , Grothe, Michel J , Bocchetta, Martina , Stoub, Travis
Alzheimer's & Dementia | September 27, 2014 | Volume: 11 | Issue: 2 | Pages: 111-125
Abstract Background An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance. Methods Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web‐platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T. Results The agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P < .001), and physiological variability (49.2%, P < .001). Conclusions The HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms.
O4‐07‐03: PATHOLOGIC VALIDATION OF THE EADC‐ADNI HARMONIZED HIPPOCAMPAL PROTOCOL
Apostolova, Liana G. , Zarow, Chris, Biado, Kristina, Hurtz, Sona, Honarpisheh, Hedieh, Blanken, Anna E., Brook, Jenny , Tung, Spencer, Ng, Denise , Alger, Jeffrey, Vinters, Harry V. , Bocchetta, Martina , Duvernoy, Henri M., Frisoni, Giovanni, Boccardi, Marina , Somme, Johanne Hatteland , Jack, Clifford R. , Bocchetta, Martina
Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_4 | Pages: No page available
Delphi definition of the EADC‐ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance
Boccardi, Marina , Bocchetta, Martina , Apostolova, Liana G. , Barnes, Josephine , Bartzokis, George, Corbetta, Gabriele , DeCarli, Charles , deToledo‐Morrell, Leyla, Ganzola, Rossana , Gerritsen, Lotte , Henneman, Wouter J.P., Malykhin, Nikolai , Pasqualetti, Patrizio , Pruessner, Jens C. , Redolfi, Alberto , Robitaille, Nicolas , Tolomeo, Daniele , Watson, Craig, Duvernoy, Henri M., Duchesne, Simon , Jack, Clifford R. , Frisoni, Giovanni B. , Segmentation, EADC‐ADNI Working Group on the Harmonized Protocol for Manual Hippocampal, Boccardi, Marina , Frisoni, Giovanni B. , DeCarli, Charles , Firbank, Michael John , Killiany, Ronald , Soininen, Hilkka S. , Wang, Lei , Wolf, Henrike , Segmentation, EADC‐ADNI Working Group on the Harmonized Protocol for Manual Hippocampal, Jack, Clifford R , Bocchetta, Martina
Alzheimer's & Dementia | August 15, 2014 | Volume: 11 | Issue: 2 | Pages: 126-138
Abstract Background This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)‐based manual hippocampal segmentation. Methods The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence‐based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher's and binomial tests. Results Agreement was significant on the inclusion of alveus/fimbria ( P = .021), whole hippocampal tail ( P = .013), medial border of the body according to visible morphology ( P = .0006), and on this combined set of features ( P = .001). This definition captures 100% of hippocampal tissue, 100% of Alzheimer’s disease‐related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter‐rater (0.94) estimates. Discussion Consensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol.