Citations 2
Endotherapy for and tailored approaches to treating GERD, and refractory GERD
Locke, G. Richard, Horwhat, John D., Mashimo, Hiroshi , Savarino, Edoardo , Zentilin, Patrizia , Savarino, Vincenzo , Armbruster, Steven, Wong, Roy K.H., Moawad, Fouad J. , Zerbib, Frank , Savarino, Edoardo
Annals of the New York Academy of Sciences | June 6, 2014 | Volume: 1300 | Issue: 1 | Pages: 166-186
This paper presents commentaries on how endoluminal antireflux procedures compare to laparoscopic fundoplication; new endoscopic procedures being studied to treat refractory gastroesophageal reflux disease (GERD); the new Stretta; the relationship between obesity and proton pump inhibitor (PPI) resistance; data concerning acid hypersensitivity and sensory receptors (vallinoid, TRPV1) causing refractory GERD; whether microscopic esophagitis is relevant in determining symptoms of non‐erosive reflux disease (NERD); how concomitant functional gastrointestinal disorders affect the PPI response in NERD; the evidence that a functional esophagus is associated with inflammatory bowel syndrome (IBS); the role of GABA agonists in the treatment of refractory GERD; the role of biofeedback and antidepressants in refractory GERD; and endoluminal fundoplication using the EsophyX device.
Defining esophageal landmarks, gastroesophageal reflux disease, and Barrett's esophagus
DeVault, Kenneth R. , McMahon, Barry P. , Marchese, Michele , Hejazi, Reza , McCallum, Richard W. , Savarino, Vincenzo , Zentilin, Patrizia , Savarino, Edoardo , Thomson, Mike , Souza, Rhonda F. , Donohoe, Claire L. , O’Farrell, Naoimh J. , Reynolds, John V. , DeVault, Kenneth, Çelebi, Altay , Costamagna, Guido , Clarke, John O. , Savarino, Edoardo
Annals of the New York Academy of Sciences | January 6, 2014 | Volume: 1300 | Issue: 1 | Pages: 278-295
The following paper on gastroesophageal reflux disease (GERD) and Barrett's esophagus (BE) includes commentaries on defining esophageal landmarks; new techniques for evaluating upper esophageal sphincter (UES) tone; differential diagnosis of GERD, BE, and hiatal hernia (HH); the use of high‐resolution manometry for evaluation of reflux; the role of fundic relaxation in reflux; the use of 24‐h esophageal pH–impedance testing in differentiating acid from nonacid reflux and its potential inclusion in future Rome criteria; classification of endoscopic findings in GERD; the search for the cell origin that generates BE; and the relationship between BE, Barrett's carcinoma, and obesity.