Citations 2
Emerging directions in tauopathy research
Wildsmith, Kristin R., Alladi, Suvarna, Bertucci, Taylor, Bowles, Kathryn R. , Boxer, Adam, Brummet, Jennifer, DeVos, Sarah L., Diaz, Kristophe , Duff, Karen, Duran‐Aniotz, Claudia, Farrell, Kurt, Fontana, Igor C., Franzmeier, Nicolai, Frost, Bess, Petrucelli, Leonard, Rexach, Jessica, Reyderman, Larisa, Rommel, Amy, Bohórquez, Sandra M. Sanabria, Schöll, Michael, Schneider, Anja, Silva, Rohan de , Snyder, Heather M. , VandeVrede, Lawren, Varga, Andrew W, Vogel, Jacob W., Yeh, Felix L. , Yoo, Andrew S., Carrillo, Maria C., Duff, Karen , Bertucci, Taylor , Mahinrad, Simin , Buée, Luc , Alladi, Suvarna , Boche, Delphine , DeVos, Sarah L. , Dreyer, Anna J. , Duran‐Aniotz, Claudia , Durrant, Claire S. , Farrell, Kurt , Fontana, Igor C. , Franzmeier, Nicolai , Frost, Bess , Horie, Kanta , Kaňovský, Petr , Kao, Aimee W. , Mahinrad, Simin , Malpetti, Maura , Morris, Huw R. , Palleis, Carla , Petrucelli, Leonard , Rexach, Jessica E. , Reyderman, Larisa, Rowe, James B. , Bohórquez, Sandra Sanabria , Sato, Chihiro , Schneider, Anja , VandeVrede, Lawren , Varga, Andrew W. , Vogel, Jacob W. , Yoo, Andrew S.J. , Carrillo, María C.
Alzheimer's & Dementia | June 22, 2026 | Volume: 22 | Issue: 6 | Pages: No page available
Abstract The Tau Global Conference 2025, hosted by the Alzheimer's Association, CurePSP, and the Rainwater Charitable Foundation, convened international experts from academia, industry, government, and philanthropy to explore advances and challenges in tauopathy research. The meeting highlighted progress across tau biology, including emerging models of tau regulation, degradation, and propagation; advances in biomarker development for the diagnosis and staging of tauopathies; and evolving therapeutic strategies targeting diverse aspects of tau pathophysiology. Discussions also emphasized the importance of cross‐sector collaboration, and global initiatives to address disparities in tau research. This report synthesizes key insights from the conference and underscores the critical role of interdisciplinary, biomarker‐driven, and globally inclusive approaches in accelerating the translation of tau research into effective clinical applications.
Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus
Čarná, Mária , Onyango, Isaac G. , Katina, Stanislav , Holub, Dušan , Nezvedová, Markéta , Jha, Durga , Nedelská, Zuzana , Lacovich, Valentina , Houbrechts, Ruben, Garcia‐Mansfield, Krystine , David‐Dirgo, Victoria , Texlova, Kateřina, Bakkar, Nadine , Pertierra, Lucía , Vinkler, Mojmír, Marková, Hana, Laczó, Jan , Kohoutková, Marcela Hortová , Frič, Jan , Forte, Giancarlo , Bělašková, Silvie , Seyfried, Nicholas T. , Bowser, Robert , Pirrotte, Patrick , Dammer, Eric B. , Limbäck‐Stokin, Clara, Stokin, Gorazd B. , Nedelska, Zuzana , Dammer, Eric B , Novotný, Jan , Vyvere, Thijs Vande , Sharma, Ritin , Vyhnálek, Martin , Chaves, Hernán , Sheardová, Kateřina , Kaňovský, Petr , Damborský, Jiřı́ , Hort, Jakub , Sevlever, Gustavo Emilio , Rissman, Robert A. , Smith, Richard Alan , Hajduch, Marian , Spáčil, Zdeněk
Alzheimer's & Dementia | February 24, 2023 | Volume: 19 | Issue: 8 | Pages: 3537-3554
Abstract The choroid plexus (ChP) produces and is bathed in the cerebrospinal fluid (CSF), which in aging and Alzheimer's disease (AD) shows extensive proteomic alterations including evidence of inflammation. Considering inflammation hampers functions of the involved tissues, the CSF abnormalities reported in these conditions are suggestive of ChP injury. Indeed, several studies document ChP damage in aging and AD, which nevertheless remains to be systematically characterized. We here report that the changes elicited in the CSF by AD are consistent with a perturbed aging process and accompanied by aberrant accumulation of inflammatory signals and metabolically active proteins in the ChP. Magnetic resonance imaging (MRI) imaging shows that these molecular aberrancies correspond to significant remodeling of ChP in AD, which correlates with aging and cognitive decline. Collectively, our preliminary post‐mortem and in vivo findings reveal a repertoire of ChP pathologies indicative of its dysfunction and involvement in the pathogenesis of AD. Highlights Cerebrospinal fluid changes associated with aging are perturbed in Alzheimer's disease Paradoxically, in Alzheimer's disease, the choroid plexus exhibits increased cytokine levels without evidence of inflammatory activation or infiltrates In Alzheimer's disease, increased choroid plexus volumes correlate with age and cognitive performance