Back to Authors

Lee, Amani

0000-0003-2687-3582

Mayo Clinic

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States.

Citations 3

Ethanol reshapes FFC-driven steatohepatitis through time-dependent fibrosis and lipid-droplet remodeling
Weninger, Jasmin , Lee, Amani L. , Marek, George , Lange, Naomi F. , Mauer, Amy S. , Puri, Gyanendra, Shah, Vijay H. , Malhi, Harmeet , Lee, Amani , Marek, George W , Lange, Naomi , Malhi, Harmeet

American Journal of Physiology-Gastrointestinal and Liver Physiology | August 22, 2026 | Volume: 331 | Issue: 4 | Pages: G399-G413

10.1152/ajpgi.00223.2026 Get It

This study presents a refined murine MetALD model designed to distinguish ethanol-modified features from FFC-driven metabolic steatohepatitis. Chronic ethanol did not uniformly worsen liver injury. Instead, it selectively modified disease trajectory through greater early collagen-positive fibrotic remodeling, altering lipid-droplet architecture, and context-dependent inflammatory chemokine signaling. By 24 wk, FFC and FFC/ethanol injury programs converged, supporting MetALD as a timing- and pathway-dependent modification of metabolic steatohepatitis.
Efficacy and Toxicity Analysis of Selective BET Bromodomain Inhibitors in Models of Inflammatory Liver Disease
Doskey, Luke C. , Scholtz, Cole R. , Vail, Nora R. , Khanal, Shalil , Lee, Amani L. , Kandanur, Sai Giridhar Sarma , Hoell, Zachariah J. , Huehls, Amelia M. , Issa, Mohamed, Cao, Sheng , Shah, Vijay H. , Issa, Mohamed R , Reid, Joel M , Pomerantz, William C K , Lee, Amani , Kostallari, Enis , Reid, Joel M. , Malhi, Harmeet , Pomerantz, William C. K.

Journal of Medicinal Chemistry | April 14, 2025 | Volume: 68 | Issue: 8 | Pages: 8091-8105

10.1021/acs.jmedchem.4c02555 Get It

A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes
Cui, Huarui , Divakaran, Anand , Hoell, Zachariah J. , Ellingson, Mikael O., Scholtz, Cole R. , Zahid, Huda , Johnson, Jorden A., Griffith, Elizabeth C., Gee, Clifford T. , Lee, Amani L. , Khanal, Shalil , Shi, Ke , Aihara, Hideki , Shah, Vijay H. , Lee, Richard , Lee, Richard E , Harki, Daniel A , Pomerantz, William C K , Harki, Daniel A. , Pomerantz, William C. K. , Lee, Amani

Journal of Medicinal Chemistry | January 10, 2022 | Volume: 65 | Issue: 3 | Pages: 2342-2360

10.1021/acs.jmedchem.1c01779 Get It