Citations 1
Ethanol reshapes FFC-driven steatohepatitis through time-dependent fibrosis and lipid-droplet remodeling
Weninger, Jasmin , Lee, Amani L. , Marek, George , Lange, Naomi F. , Mauer, Amy S. , Puri, Gyanendra, Shah, Vijay H. , Malhi, Harmeet , Lee, Amani , Marek, George W , Lange, Naomi , Malhi, Harmeet
American Journal of Physiology-Gastrointestinal and Liver Physiology | August 22, 2026 | Volume: 331 | Issue: 4 | Pages: G399-G413
This study presents a refined murine MetALD model designed to distinguish ethanol-modified features from FFC-driven metabolic steatohepatitis. Chronic ethanol did not uniformly worsen liver injury. Instead, it selectively modified disease trajectory through greater early collagen-positive fibrotic remodeling, altering lipid-droplet architecture, and context-dependent inflammatory chemokine signaling. By 24 wk, FFC and FFC/ethanol injury programs converged, supporting MetALD as a timing- and pathway-dependent modification of metabolic steatohepatitis.