Citations 4
Toward actionable interventions in human aging (12th ARDD meeting, 2025)
Dekan, Aleksandr , Lore, Sierra , Yoon, Ye Eun, Sjöholm, Aisyah, Terskikh, Alexey V. , Cuervo, A. M., Georgievskaya, Anastasia , Heinz, Andrea , Adams, Andrew, Tsai, Andy P. , Murray, Anna, Brunet, Anne , Harten, Anne Marije van, Spier, Avi, Shenhar, Ben , Clasen, Berthil, Volbracht, Christiane , Kuppe, Christoph, Cookson, Clive, Banila, Cristiana , Cai, Daisy, Lamming, Dudley W. , Rudnic, Edward, Samra, Elias Bou , Verdin, Eric, Fagagna, Fabrizio d’Adda di, Zmudze, Garri, Jasper, Heinrich, Jang, In Hwa, Lemaitre, J. M., Betts-LaCroix, Joe , Newman, John C. , Kawamura, Kazuto , Schaal, Kennedy Matsagas, Egerton, Kitsu, Fortney, Kristen , Hartenstein, Lars, Niedernhofer, Laura, Katsimpardi, Lida , Melton, Lisa , Ferrucci, Luigi, Sylow, Lykke, Demaria, Marco , Guasch-Ferré, Marta, Borch-Jensen, Martin, Kholin, Maxim, Antonov, Michael, Deleidi, Michela , Mérad, Miriam , Meldal, Morten, Topors, Mourad, Venkatesan, Murali, LeBrasseur, Nathan K., Anzinger, Niklas, Fedichev, Peter O, Kohlhaas, Paul, Mullen, Peter J., Singhal, Priya , Cabo, Raquel, Montgomery, Rusty L. , Rosenzweig-Lipson, Sharon, Jakimov, Sergey, Austad, Steven N. , White, Todd, Zuber, Tom, Rozmaric, Tomaz , Wyss-Coray, Tony, Gladyshev, Vadim N., Sinatti, Vanessa V. C., Wang, Weilan, Harborne, William, Wang, Xing Li, Suh, Yousin , Lee, Y., Koch, Zane, Scheibye-Knudsen, Morten, Niedernhofer, Laura J. , Wyss‐Coray, Tony , Niedernhofer, Laura J , Lamming, Dudley W , Deleidi, Michela , Wyss-Coray, Tony , Bakula, Daniela , Tyshkovskiy, Alexander , Cuervo, Ana M , Seluanov, Andrei , Murray, Anna , Pedersen, Bente Klarlund , Schumacher, Björn , Kennedy, Brian Keith , Suetta, Charlotte , Kuppe, Christoph , Ewald, Collin Y. , Valenzano, Dario Riccardo , Rudnic, Edward M., Teeling, Emma C. , Verdin, Eric , Fang, Evandro Fei , Fagagna, Fabrizio d’Adda di , Galkin, Fedor , Jasper, Heinrich , Jang, In Hwa , Han, Jing‐Dong J. , Justice, Jamie N. , Hoeijmakers, Jan H.J. , Ramos, Javier María Peralta , Lemaı̂tre, Jean-Marc , Aerssens, Jeroen , Belmonte, Juan Carlos Izpisúa , Abdelmohsen, Kotb , Knudsen, Lotte Bjerre , Ferrucci, Luigi , Sylow, Lykke , Schafer, Marissa , Guasch‐Ferré, Marta , Levitt, Michael R. , Meldal, Morten , Fedichev, Peter O. , Mullen, Peter J. , Cabo, Rafael de, Houtkooper, Riekelt H. , Smith, Ryan , Rosenzweig‐Lipson, Sharon, Horvath, Steve , Rando, Thomas A. , White, Todd, Tammela, Tuomas , Gladyshev, Vadim N. , Sinatti, Vanessa V C , Liu, Xiaodong , Suh, Yousin , Koch, Zane , Zhavoronkov, Alex , Scheibye‐Knudsen, Morten
Aging | April 6, 2026 | Volume: 18 | Issue: 1 | Pages: 282-302
The Fifth Annual Symposium of the Midwest Aging Consortium
Reader, Brenda F. , Rosas, Lorena , Knopf, Bailey A. , Liu, Yang , Bhat, Ajay , Carey, Anna , Elliehausen, Christian J., Englund, Davis A. , Hamilton, H., Johnston, Matthew , Kang, Ping, Konopka, Adam R. , Lepola, Noah, Schafer, Marissa , Singer, Benjamin D. , Song, Min‐Ae , Wei, Wei , Zhang, Lei , Zhang, Lei , Lamming, Dudley W. , Knopf, Bailey Anna , Bhat, Ajay , Carey, Anna , Konopka, Adam R , Presley, Carolyn J , Zhang, Lei , Zhang, Lei , Anderson, Rozalyn M , Bai, Hua , Lamming, Dudley W , Schafer, Marissa J , Englund, Davis A. , Alzate‐Correa, Diego , Cuervo, Ana M , Dayal, Sanjana , Demarco, Rafael Sênos , Kang, Ping, Lepola, Noah , Presley, Carolyn J. , Serrano, Joan , Stanford, Kristin I. , Taylor, Jackson R. , Yeh, Chung‐Yang , Anderson, Rozalyn M. , Robbins, Paul D. , Mihaylova, Maria M. , Rojas, Mauricio M. , Mora, Ana Lucia
The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences | December 20, 2024 | Volume: 80 | Issue: 2 | Pages: No page available
Abstract As the healthcare burden caused by an increasingly aging population rapidly rises, a pressing need exists for innovative geroscience research that can elucidate aging mechanisms and precipitate the development of therapeutic interventions to support healthy aging. The Fifth Annual Midwest Aging Consortium Aging Research symposium, held from April 28 to 30, 2024, was hosted by The Ohio State University in Columbus, Ohio, and featured presentations from investigators across the Midwestern United States. This report summarizes the research presented at the symposium, whose topics included cellular senescence and the aging brain, metabolism and metabolic interventions, nutrition, redox mechanisms and biomarkers, and stress mechanisms. Abstract presentations and short talks highlighted early-stage and young investigators, whereas 2 keynote presentations anchored the symposium. Overall, this symposium showed the robustness of aging research in the Midwest and underscored the advantages of a collaborative approach to geroscience research.
TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy
Alquezar, Carolina , Schoch, Kathleen M. , Geier, Ethan G., Ramos, Eliana Marisa , Scrivo, Aurora , Li, Kathy H., Argouarch, Andrea R. , Mlynarski, Elisabeth E. , Dombroski, Beth A. , DeTure, Michael , Yokoyama, Jennifer S. , Burlingame, Alma L. , Schellenberg, Gerard D. , Miller, Timothy M. , Miller, Bruce L. , Dombroski, Beth , Dickson, Dennis W , Cuervo, Ana M , Burlingame, Alma L , Schellenberg, Gerard D , Miller, Timothy M , Miller, Bruce L , Kao, Aimee W. , DeTure, Michael , Yokoyama, Jennifer , Alquezar, Carolina , Dickson, Dennis W.
Science Advances | November 5, 2021 | Volume: 7 | Issue: 45 | Pages: No page available
TSC1/hamartin haploinsufficiency increases risk for tauopathy by promoting tau acetylation and accumulation.
Extending human healthspan and longevity: a symposium report
DeVito, Loren M., Barzilai, Nir , Niedernhofer, Laura J. , Milman, Sofiya , Ferrucci, Luigi , Kuchel, George A. , Mannick, Joan B. , Gonzales, Mitzi M. , Kirkland, James L. , Campisi, Judith , Niedernhofer, Laura J , Ferrucci, Luigi , Kuchel, George A , Gonzales, Mitzi , Cuervo, Ana M , Levine, Morgan E. , Promislow, Daniel , Justice, Jamie N. , Cohen, Pinchas
Annals of the New York Academy of Sciences | September 9, 2021 | Volume: 1507 | Issue: 1 | Pages: 70-83
AbstractFor many years, it was believed that the aging process was inevitable and that age‐related diseases could not be prevented or reversed. The geroscience hypothesis, however, posits that aging is, in fact, malleable and, by targeting the hallmarks of biological aging, it is indeed possible to alleviate age‐related diseases and dysfunction and extend longevity. This field of geroscience thus aims to prevent the development of multiple disorders with age, thereby extending healthspan, with the reduction of morbidity toward the end of life. Experts in the field have made remarkable advancements in understanding the mechanisms underlying biological aging and identified ways to target aging pathways using both novel agents and repurposed therapies. While geroscience researchers currently face significant barriers in bringing therapies through clinical development, proof‐of‐concept studies, as well as early‐stage clinical trials, are underway to assess the feasibility of drug evaluation and lay a regulatory foundation for future FDA approvals in the future.