Citations 3
Plasma proteomics reveals divergent sex-specific senescence and bone biology signatures across neurodegenerative diseases
Kaipa, Siddharth, Moran-Losada, Patricia, He, Zihuai, Channappa, Divya, Oh, Hamilton Se-Hwee , Rutledge, Jarod, Zeineh, Michael , Agudelo, Anthony, Nair, R, Wilson, Edward N., Raghuraman, Keerthana, Al-Rajhi, Amal, Akkiraju, Anika, Hwang, Janet, Longo, Frank M., Ramirez, Veronica, Poston, Kathleen, Wyss‐Coray, Tony , Henderson, Victor W., He, Zihuai , Poston, Kathleen L. , Se-Hwee Oh, Hamilton , Zeineh, Michael , Khosla, Sundeep , Wyss-Coray, Tony , Suryadevara, Vidyani , Zhai, Ting , Meka, Sai Rama Krishna , Moran‐Losada, Patricia, Rutledge, Jarod , Nair, Ramesh V. , Wilson, Edward N. , Bandela, Mounica , Longo, Frank M. , Neretti, Nicola , Khosla, Sundeep , Snyder, Michael , Henderson, Victor W.
No container title available | May 27, 2026 | Volume: No volume available | Issue: No issue available | Pages: No page available
SUMMARY Neurodegenerative diseases are often accompanied by systemic comorbidities, including changes in bone health, but the molecular relationship between neurodegeneration, skeletal decline, and cellular senescence remains poorly understood. In this study, we investigated sex-specific changes in circulating bone- and senescence-related proteins across the spectrum of Alzheimer’s disease(AD), Lewbody dementia(LB) and Parkinson’s disease(PD). Plasma proteomic profiling was performed on samples from 408 participants deeply phenotyped for neurodegenerative diseases, followed by differential protein and pathway analyses. This study reveals sex-dependent alterations in bone and senescence-related circulating proteins in AD-related, PD and LB-related neurodegenerative diseases, providing insights into the complex relationship between neurodegeneration and bone health. Several candidate proteins were also associated with established plasma neurodegeneration biomarkers, particularly pTau181. Pathway analyses revealed shared mitochondrial and metabolic dysfunction across neurodegenerative diseases, with disease-specific features including vesicle trafficking disruption in AD and inflammatory-senescence pathways in LB, plus sex-divergent patterns in inflammatory signaling and bone-related pathways.
Toward actionable interventions in human aging (12th ARDD meeting, 2025)
Dekan, Aleksandr , Lore, Sierra , Yoon, Ye Eun, Sjöholm, Aisyah, Terskikh, Alexey V. , Cuervo, A. M., Georgievskaya, Anastasia , Heinz, Andrea , Adams, Andrew, Tsai, Andy P. , Murray, Anna, Brunet, Anne , Harten, Anne Marije van, Spier, Avi, Shenhar, Ben , Clasen, Berthil, Volbracht, Christiane , Kuppe, Christoph, Cookson, Clive, Banila, Cristiana , Cai, Daisy, Lamming, Dudley W. , Rudnic, Edward, Samra, Elias Bou , Verdin, Eric, Fagagna, Fabrizio d’Adda di, Zmudze, Garri, Jasper, Heinrich, Jang, In Hwa, Lemaitre, J. M., Betts-LaCroix, Joe , Newman, John C. , Kawamura, Kazuto , Schaal, Kennedy Matsagas, Egerton, Kitsu, Fortney, Kristen , Hartenstein, Lars, Niedernhofer, Laura, Katsimpardi, Lida , Melton, Lisa , Ferrucci, Luigi, Sylow, Lykke, Demaria, Marco , Guasch-Ferré, Marta, Borch-Jensen, Martin, Kholin, Maxim, Antonov, Michael, Deleidi, Michela , Mérad, Miriam , Meldal, Morten, Topors, Mourad, Venkatesan, Murali, LeBrasseur, Nathan K., Anzinger, Niklas, Fedichev, Peter O, Kohlhaas, Paul, Mullen, Peter J., Singhal, Priya , Cabo, Raquel, Montgomery, Rusty L. , Rosenzweig-Lipson, Sharon, Jakimov, Sergey, Austad, Steven N. , White, Todd, Zuber, Tom, Rozmaric, Tomaz , Wyss-Coray, Tony, Gladyshev, Vadim N., Sinatti, Vanessa V. C., Wang, Weilan, Harborne, William, Wang, Xing Li, Suh, Yousin , Lee, Y., Koch, Zane, Scheibye-Knudsen, Morten, Niedernhofer, Laura J. , Wyss‐Coray, Tony , Niedernhofer, Laura J , Lamming, Dudley W , Deleidi, Michela , Wyss-Coray, Tony , Bakula, Daniela , Tyshkovskiy, Alexander , Cuervo, Ana M , Seluanov, Andrei , Murray, Anna , Pedersen, Bente Klarlund , Schumacher, Björn , Kennedy, Brian Keith , Suetta, Charlotte , Kuppe, Christoph , Ewald, Collin Y. , Valenzano, Dario Riccardo , Rudnic, Edward M., Teeling, Emma C. , Verdin, Eric , Fang, Evandro Fei , Fagagna, Fabrizio d’Adda di , Galkin, Fedor , Jasper, Heinrich , Jang, In Hwa , Han, Jing‐Dong J. , Justice, Jamie N. , Hoeijmakers, Jan H.J. , Ramos, Javier María Peralta , Lemaı̂tre, Jean-Marc , Aerssens, Jeroen , Belmonte, Juan Carlos Izpisúa , Abdelmohsen, Kotb , Knudsen, Lotte Bjerre , Ferrucci, Luigi , Sylow, Lykke , Schafer, Marissa , Guasch‐Ferré, Marta , Levitt, Michael R. , Meldal, Morten , Fedichev, Peter O. , Mullen, Peter J. , Cabo, Rafael de, Houtkooper, Riekelt H. , Smith, Ryan , Rosenzweig‐Lipson, Sharon, Horvath, Steve , Rando, Thomas A. , White, Todd, Tammela, Tuomas , Gladyshev, Vadim N. , Sinatti, Vanessa V C , Liu, Xiaodong , Suh, Yousin , Koch, Zane , Zhavoronkov, Alex , Scheibye‐Knudsen, Morten
Aging | April 6, 2026 | Volume: 18 | Issue: 1 | Pages: 282-302
Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity
Lyu, Yu-Xuan, Wilczok, Dominika , Antebi, Adam , Vojta, Aleksandar , Stolzing, Alexandra , Moskalev, Alexey , Georgievskaya, Anastasia , Maier, Andrea B. , Olsen, Andrea, Groth, Anja , Brunet, Anne , Jamil, Aisyah, Kulaga, Anton , Bhatti, A.R., Yaden, Benjamin C., Djordjevic, Boris, Chen, Chieh, Huang, Christine Yuan, Chen, Danica , Sołdacki, Dariusz, Meyer, David H. , Chini, Eduardo N. , Morgen, Eric , Vernet, Erik , Pinilla, Estefano, Mercken, Evi M. , Finger, Fabian , Kuipers, Folkert , Gyülvészi, Gábor, Zmudze, Garri, Blander, Gil , Pincus, Harold A., McClure, Joshua, Kirkland, James L. , Peyer, James , McLaughlin, Jerry L., Mannick, Joan B. , Betts-LaCroix, Joe , Sedivy, John M. , Speakman, John R. , Shlain, Jordan, Maltzahn, Julia von , Andreasson, Katrin I. , Moody, Kelsey , Fortney, Kristen , Niedernhofer, Laura J., Veenhoff, Liesbeth M. , Melton, Lisa , Quarta, Marco , Koval, Maria, Marinova, Maria B., Hamalainen, Mark, Unfried, Maximilian , Ringel, Michael S. , Filipović, Miloš R. , Topors, Mourad, Mitin, Natalia , Roy, N. N., Pintar, Nika, Barzilai, Nir , Binetti, Paolo, Kohlhaas, Paul, Rubin, Paul , Kamya, Petrina, Muñoz‐Cánoves, Pura , Конрад, Р. , Ripa, Roberto , Mansukhani, Robin, Büttner, Sabrina , Brunemeier, Sebastian, Jakimov, Sergey, Rosenzweig‐Lipson, Sharon, Tsai, Shih‐Yin , Rando, Thomas A. , Peterson, Timothy R. , Woods, Tina , Wyss‐Coray, Tony , Finkel, Toren , Strauss, Tzipora , Longo, Valter D. , Sorrentino, Vincenzo , Sebastiano, Vittorio , Li, Wenbin , Suh, Yousin , Niedernhofer, Laura J. , Lu, Yuxuan , Passos, Joao, Niedernhofer, Laura J , Wyss-Coray, Tony , Bakula, Daniela , Lyu, Yu-Xuan, Fu, Qiang , Ying, Kejun , King, Aaron, Olsen, Andrea, Simon, Anna Katharina , Jamil, Aisyah, Bhatti, Asif, Pedersen, Bente Klarlund , Schumacher, Björn , Kennedy, Brian Keith , Huang, Christine Yuan, Correll, Christoph Ulrich , Murphy, Coleen Tara , Ewald, Collin Y. , Valenzano, Dario Riccardo , Erritzøe, David , Sinclair, David , Teeling, Emma C. , Verdin, Eric , Pinilla, Estéfano , Fang, Evandro Fei , Bischof, Evelyne Y. , Pun, Frank W. , Civiletto, Gabriele , Justice, Jamie N. , Vijg, Jan , Gruhn, Jennifer R. , McLaughlin, Jerry, Passos, João F. , Baur, Joseph A. , Shlain, Jordan, Palikaras, Konstantinos , Rasmussen, Lene Juel , Ferrucci, Luigi , Koval, Maria, Topors, Mourad, Roy, Nawal, Pintar, Nika , Singh, Parminder Pal , Robbins, Paul D. , Fedichev, Peter O. , Cabo, Rafael de , Faragher, Richard , Konrad, Rob, Wickström, Sara A. , Brunemeier, Sebastian A., Luo, Shan , Dimmeler, Stefanie , Gladyshev, Vadim N. , Dwaraka, Varun B. , Gorbunova, Vera , Acosta-Rodríguez, Victoria A. , Suh, Yousin , Zhavoronkov, Alex , Scheibye‐Knudsen, Morten
Aging | October 16, 2024 | Volume: No volume available | Issue: No issue available | Pages: No page available