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Ballard, Clive

0000-0003-0022-5632

Mayo Clinic

From the Newcastle University (I.G.M., A.J.T., P.D., J.P.T.); Mayo Clinic (T.J.F.), Jacksonville; University of Strasbourg (F.B.); Mayo Clinic (B.F.B., K.K.), Rochester; Nagoya University (H.F.), Kawasaki Memorial Hospital; Istituto Neurologico "Carlo Best

Citations 3

Revisiting Criteria for Psychosis in Alzheimer’s Disease and Related Dementias: Toward Better Phenotypic Classification and Biomarker Research
Ismail, Zahinoor , Youakim, James M. , Kumar, Sanjeev , Núñez, Nicolás A. , Darby, R. Ryan , D’Antonio, Fabrizia , Lena, Carlo de , McGeown, William J. , Ravona, Ramit, Rasmussen, J , Bell, J. Simon , Wang, Huali , Bruneau, Marie‐Andrée , Agüera-Ortíz, Luis , Lyketsos, Constantine G. , Sano, Mary , Devanand, Davangere P. , Ballard, Clive , Nunez, Nicolas, Ballard, Clive , Fischer, Corinne Eleanor , Creese, Byron , Vita, Antonella Di , Panegyres, Peter K. , Lanctôt, Krista L. , Cummings, Jeffrey L. , Jeste, Dilip V. , Sweet, Robert A.

Journal of Alzheimer’s Disease | December 27, 2019 | Volume: 73 | Issue: 3 | Pages: 1143-1156

10.3233/jad-190828 Get It

Background: Psychotic symptoms are common in Alzheimer’s disease (AD) and related neurodegenerative disorders and are associated with more rapid disease progression and increased mortality. It is unclear to what degree existing criteria are utilized in clinical research and practice. Objective: To establish research criteria for the diagnosis of psychosis in AD. Methods: The International Society to Advance Alzheimer’s Research and Treatment (ISTAART) Neuropsychiatric Symptoms (NPS) Professional Interest Area (PIA) psychosis subgroup reviewed existing criteria for psychosis in AD and related dementias. Through a series of in person and on-line meetings, a priority checklist was devised to capture features necessary for current research and clinical needs. PubMed, Medline and other relevant databases were searched for relevant criteria. Results: Consensus identified three sets of criteria suitable for review including those of Jeste and Finkel, Lyketsos, and the Diagnostic and Statistical Manual for Mental Disorders, 5th edition. It was concluded that existing criteria could be augmented by including a more specific differentiation between delusions and hallucinations, address overlap with related conditions (agitation in particular), adding the possibility of symptoms emerging in the preclinical and prodromal phases, and building on developing research in disease biomarkers. Conclusion: We propose criteria, developed to improve phenotypic classification of psychosis in AD, and advance the research agenda in the field to improve epidemiological, biomarker, and genetics research in the field. These criteria serve as a complement to the International Psychogeriatric Association criteria for psychosis in neurocognitive disorders.
Neuropsychiatric symptoms in Alzheimer's disease: Past progress and anticipation of the future
Geda, Yonas E. , Schneider, Lon S. , Gitlin, Laura N. , Smith, Gwenn S. , Evans, Jovier D., Lee, Michael K. , Porsteinsson, Anton P. , Lanctôt, Krista L. , Rosenberg, Paul B. , Sultzer, David L. , Francis, Paul T. , Brodaty, Henry , Padala, Prasad P., Onyike, Chiadikaobi, Ortiz, Luis Agüera, Vitiello, Michael V. , Yaffe, Kristine , Zee, Phyllis C. , Herrmann, Nathan , Ballard, Clive , Khin, Ni A. , Alfaro, Cara L., Murray, Patrick S. , Schultz, Susan K. , Lyketsos, Constantine G. , ISTAART, Neuropsychiatric Syndromes Professional Interest Area of, Miller, David S. , Bell, J. Simon , Padala, Prasad R. , Ancoli‐Israel, Sonia , Bliwise, Donald L. , Martin, Jennifer L. , Sweet, Robert A. , ISTAART, Neuropsychiatric Syndromes Professional Interest Area of, Lanctôt, Krista L , Brodaty, Henry , Ballard, Clive , Geda, Yonas E

Alzheimer's & Dementia | April 4, 2013 | Volume: 9 | Issue: 5 | Pages: 602-608

10.1016/j.jalz.2012.12.001 Get It

Abstract Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) are widespread and disabling. This has been known since Dr. Alois Alzheimer's first case, Frau Auguste D., presented with emotional distress and delusions of infidelity/excessive jealousy, followed by cognitive symptoms. Being cognizant of this, in 2010 the Alzheimer's Association convened a research roundtable on the topic of NPS in AD. A major outcome of the roundtable was the founding of a Professional Interest Area (PIA) within the International Society to Advance Alzheimer's Research and Treatment (ISTAART). The NPS‐PIA has prepared a series of documents that are intended to summarize the literature and provide more detailed specific recommendations for NPS research. This overview paper is the first of these living documents that will be updated periodically as the science advances. The overview is followed by syndrome‐specific synthetic reviews and recommendations prepared by NPS‐PIA workgroups on depression, apathy, sleep, agitation, and psychosis.