Weinshenker, Brian G

Mayo Clinic

From the Department of Neurology (S.S.S., M.B., D.T., B.G.W., S.J.P., E.P.F., M.T.B., J.J.C.), and Center for Multiple Sclerosis and Autoimmune Neurology (S.S.S., M.B., D.M.W., B.G.W., S.J.P., E.P.F., J.J.C.), Mayo Clinic, Rochester, MN; Department of Neur

Citations 140

Western vs optic-spinal MS

Weinshenker, Brian, Weinshenker, Brian G. , Weinshenker, Brian G

Neurology | June 14, 2011 | Volume: 64 | Issue: 4 | Pages: 594-595

10.1212/01.wnl.0000154673.37555.6f

Paraneoplastic isolated myelopathy

Flanagan, Eoin P. , McKeon, Andrew , Lennon, Vanda A. , Kearns, John E., Weinshenker, B. G., Krecke, Karl N. , Matiello, Marcelo , Mokri, Bahram, Aksamit, Allen J. , Pittock, Sean J. , Weinshenker, Brian G. , Keegan, B. Mark , Pittock, S J , Flanagan, E P , Weinshenker, Brian G , McKeon, Andrew

Neurology | June 14, 2011 | Volume: 76 | Issue: 24 | Pages: 2089-2095

10.1212/wnl.0b013e31821f468f

Neuromyelitis optica unique area postrema lesions

Popescu, Bogdan F. Gh., Lennon, Vanda A. , Parisi, Joseph E. , Howe, Charles L. , Weigand, Stephen D. , Cabrera-Gómez, JA , Newell, Kathy L. , Mandler, Raúl N. , Pittock, Sean J. , Weinshenker, Brian G. , Lucchinetti, Claudia F. , Pittock, S J , Weinshenker, Brian G , Howe, Charles L

Neurology | March 3, 2011 | Volume: 76 | Issue: 14 | Pages: 1229-1237

10.1212/wnl.0b013e318214332c

Do old HLA and mitochondrial DNA variants associate with demyelination types in young patients?

Kálmán, Bernadette , Weinshenker, Brian G. , Weinshenker, Brian G

Neurology | February 3, 2011 | Volume: 76 | Issue: 9 | Pages: 768-769

10.1212/wnl.0b013e31820e7bfc

Pearls & Oy-sters: Clues for spinal dural arteriovenous fistulae

McKeon, Andrew , Lindell, E. Paul , Atkinson, J.L.D. , Weinshenker, Brian G. , Piepgras, D. G., Pittock, Sean J. , Pittock, S J , Weinshenker, Brian G , McKeon, Andrew

Neurology | January 17, 2011 | Volume: 76 | Issue: 3 | Pages: No page available

10.1212/wnl.0b013e3182074a42

Association of IL2RA p olymorphisms with susceptibility to multiple sclerosis is not explained by missense mutations in IL2RA

Matiello, Marcelo , Weinshenker, Brian G. , Atkinson, Elizabeth J. , Schaefer-Klein, Janet, Kantarci, Orhun H. , Weinshenker, Brian G

Multiple Sclerosis Journal | January 14, 2011 | Volume: 17 | Issue: 5 | Pages: 634-636

10.1177/1352458510394703

Genome-wide association studies have identified an association between two intronic single nucleotide polymorphisms (SNPs), rs12722489 and rs2104286, in the interleukin-2 receptor alpha-chain gene ( IL2RA) and susceptibility to multiple sclerosis (MS). We studied these SNPs in association with susceptibility to and severity of MS in a population-based cohort of 220 patients from Olmsted County, Minnesota, compared with 442 matched controls. We sequenced the exons, splice sites and 5’ and 3’ untranslated regions in 27 randomly selected MS patients (powered for allele frequency ≥0.04) to search for mutations. No novel missense mutation was identified. Two patients (7.5%) had an exon 2 SNP ( rs4308625) and two patients had an exon 4 SNP ( rs2228149), both synonymous.