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Brum, Doralina Guimarães

https://orcid.org/0000-0002-9050-3319

Mayo Clinic

From the Department of Neurology (M.M., B.G.W.), Mayo Clinic, Rochester, MN; Department of Neurology (H.J.K., W.K.), National Cancer Center, Goyang, South Korea; Department of Neuroscience and Behavior (D.G.B., A.A.B.), Medical School of Riberão Preto, Un

Citations 3

Familial neuromyelitis optica
Matiello, Marcelo , Kim, H.J. , Brum, Doralina Guimarães , Barreira, Amilton Antunes , Kingsbury, D., Plant, Gordon T. , Adoni, Tarso , Weinshenker, Brian G. , Kim, Woorim , Weinshenker, Brian G

Neurology | July 26, 2010 | Volume: 75 | Issue: 4 | Pages: 310-315

10.1212/wnl.0b013e3181ea9f15 Get It

HLA-DRB1*1501 tagging rs3135388 polymorphism is not associated with neuromyelitis optica
Matiello, Marcelo , Schaefer-Klein, Janet, Brum, Doralina Guimarães , Atkinson, Elizabeth J. , Kantarci, Orhun H. , Weinshenker, Brian G. , collaborators, the NMO genetics, Weinshenker, Brian G

Multiple Sclerosis Journal | June 30, 2010 | Volume: 16 | Issue: 8 | Pages: 981-984

10.1177/1352458510374340 Get It

Background: Association of the HLA-DRB1*1501 allele with multiple sclerosis is well established, but its association with neuromyelitis optica has only been evaluated in small populations. Methods: We performed a case-control genetic association study to evaluate the association of HLA-DRB1*1501 with neuromyelitis optica. The single nucleotide polymorphism rs3135388, which tags HLA-DRB1*1501, was genotyped in 164 patients with neuromyelitis optica, 220 patients with multiple sclerosis and 959 controls matched for age, gender and ethnicity. Genotyping for rs3135388 was performed by Taqman-based 5' nuclease assay. Results: Rs3135388*A was positively associated with multiple sclerosis (OR = 3.93; 95% CI = 2.58—5.97, p = 1.18 × 10 -09 ) but negatively associated with NMO (OR = 0.57; 95% CI = 0.36—0.91, p = 0.01). Conclusions: Multiple sclerosis and neuromyelitis optica differ in their associations with DRB1*1501.
HLA-DRB association in neuromyelitis optica is different from that observed in multiple sclerosis
Brum, Doralina Guimarães , Barreira, Amilton Antunes , Kaimen-Maciel, Damacio Ramón , Matiello, Marcelo , Deghaide, Neifi Hassan Saloun, Costa, Laudo Silva, Louzada‐Júnior, Paulo , Diniz, Paula Rejane Beserra , Mendes‐Junior, Celso Teixeira , Donadi, Eduardo Antônio , Santos, Antônio Carlos dos , Costa, Roberta Martins da Silva , Comini-Frota, Elizabeth Regina

Multiple Sclerosis Journal | December 7, 2009 | Volume: 16 | Issue: 1 | Pages: 21-29

10.1177/1352458509350741 Get It

Until recently, neuromyelitis optica (NMO) was considered to be a sub-type of multiple sclerosis (MS), which has a strong predilection for Caucasian populations, whereas NMO is more frequent in non-Caucasian individuals. The objective of this study was to compare the HLA-DRB profile in Brazilian Mulatto patients with NMO spectrum disorders (NMOSDs) with that observed for Mulatto MS patients and healthy Mulatto controls. Twenty seven NMOSD patients (20 women), all seropositive for NMO-IgG, 29 MS patients and 28 Mulatto healthy blood donors were evaluated for HLA-DRB allele groups. HLA-DRB1*03 allele group was overrepresented in NMO patients compared with healthy controls (p = 0.0401; OR = 3.23, 95%CI: 1.07—9.82). In contrast, the HLA-DRB1*15 allele group was overrepresented in Brazilian MS patients (OR = 15.89, 95%CI: 3.51—71.85; p < 0.0001). DRB3 was overrepresented in NMO (p = 0.0064), and DRB5 overrepresented in MS patients (p = 0.0001). The low frequency of HLA-DRB1*15 alleles was associated with the presence of long and central cord lesions at magnetic resonance. In addition, DRB1*15 alleles were associated with the fulfillment of the Barkhof criteria. In conclusion, these results indicate that the DRB profile of NMO patients is different from that observed for MS patients, further corroborating the distinction between NMO and MS.