Citations 1
HLA-DRB1*1501 tagging rs3135388 polymorphism is not associated with neuromyelitis optica
Matiello, Marcelo , Schaefer-Klein, Janet, Brum, Doralina Guimarães , Atkinson, Elizabeth J. , Kantarci, Orhun H. , Weinshenker, Brian G. , collaborators, the NMO genetics, Weinshenker, Brian G
Multiple Sclerosis Journal | June 30, 2010 | Volume: 16 | Issue: 8 | Pages: 981-984
Background: Association of the HLA-DRB1*1501 allele with multiple sclerosis is well established, but its association with neuromyelitis optica has only been evaluated in small populations. Methods: We performed a case-control genetic association study to evaluate the association of HLA-DRB1*1501 with neuromyelitis optica. The single nucleotide polymorphism rs3135388, which tags HLA-DRB1*1501, was genotyped in 164 patients with neuromyelitis optica, 220 patients with multiple sclerosis and 959 controls matched for age, gender and ethnicity. Genotyping for rs3135388 was performed by Taqman-based 5' nuclease assay. Results: Rs3135388*A was positively associated with multiple sclerosis (OR = 3.93; 95% CI = 2.58—5.97, p = 1.18 × 10 -09 ) but negatively associated with NMO (OR = 0.57; 95% CI = 0.36—0.91, p = 0.01). Conclusions: Multiple sclerosis and neuromyelitis optica differ in their associations with DRB1*1501.