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Le Grange, Daniel

0000-0001-7293-9496

Mayo Clinic

Department of Psychiatry and Behavioral Sciences, University of California, san Francisco, San Francisco, USA.

Citations 3

Family‐Based Treatment for Primary Care: An Observational Study of a Community Sample of Youth With Restrictive Eating Disorders
Mattke, Angela, Partain, Paige , Billings, Marcie, Geske, Jennifer R. , O’Brien, Janna R. Gewirtz , Narr, Cassandra, Breland, Renee, Schmit, Tammy L. , Grange, Daniel Le , Loeb, Katharine L. , Sim, Leslie , Lebow, Jocelyn , Partain, Paige , Geske, Jennifer , Gewirtz O'Brien, Janna R , Schmit, Tammy, Le Grange, Daniel , Loeb, Katharine , Sim, Leslie A , Lebow, Jocelyn , Jacobson, Robert M.

International Journal of Eating Disorders | March 15, 2025 | Volume: 58 | Issue: 6 | Pages: 1085-1095

10.1002/eat.24416 Get It

ABSTRACTObjectiveTo examine the outcomes of a clinical sample of young patients with restrictive eating disorders who received Family‐Based Treatment for Primary Care (FBT‐PC).MethodsParticipants were 134 youth (mean age = 15.7 years) and their caregiver(s). Participants and caregivers completed measures of eating disorder symptomatology, quality of life, and caregiver self‐efficacy.ResultsOf the 134 patients who received at least one session of FBT‐PC, 55.9% completed treatment, 20.1% were followed until they began a higher level of care, and 23.8% were non‐completers. Weekly measures for the full sample were evaluated using intention‐to‐treat analyses. Patient‐reported scores on the ED‐15 improved by −0.1 (SE = 0.02, F (1,133)= 26.4, p < 0.0001) per week, and caregivers' ratings of patient symptoms also improved by 0.85 (SE = 0.2, F (1,133)=13.1, p = 0.0003) per week. Patient's BMI percentile increased by 1.25 points per week (SE = 0.14, F (1,133) = 83.9, p < 0.0001). For patients who completed FBT‐PC, eating disorder symptoms, per patient‐ (M = −1.43, p < 0.0001) and caregiver‐report (M = −1.33 p < 0.0001) decreased significantly from baseline to end of treatment. Patient's quality of life increased significantly from baseline to end of treatment (M = 21.6, p < 0.0001) and caregivers showed significant increases in self‐efficacy (M = 3.41, p < 0.0001, d = 0.856). At the end of treatment, 62.5% of patients with complete data met criteria for full research remission, and 44.6% met criteria for full clinical remission.DiscussionFindings provide preliminary support for FBT‐PC as an effective treatment for youth with restrictive eating disorders. Additional research is needed to replicate these findings in other primary care settings and to understand the durability of treatment effects.
A primary care modification of family-based treatment for adolescent restrictive eating disorders
Lebow, Jocelyn , O’Brien, Janna R. Gewirtz , Mattke, Angela, Narr, Cassandra, Geske, Jennifer R. , Billings, Marcie, Clark, Matthew M. , Grange, Daniel Le , Sim, Leslie , Geske, Jennifer, Jacobson, Robert M. , Phelan, Sean, Le Grange, Daniel , Sim, Leslie A , Lebow, Jocelyn , Geske, Jennifer , Phelan, Sean M.

Eating Disorders | November 1, 2019 | Volume: 29 | Issue: 4 | Pages: 376-389

10.1080/10640266.2019.1656468 Get It

Weight gain trajectories during outpatient family‐based treatment for adolescents with anorexia nervosa
Lebow, Jocelyn , Sim, Leslie , Goldschmidt, Andrea B. , Grange, Daniel Le , Accurso, Erin C. , Goldschmidt, Andrea B , Le Grange, Daniel , Accurso, Erin C , Lebow, Jocelyn , Crosby, Ross D.

International Journal of Eating Disorders | December 22, 2018 | Volume: 52 | Issue: 1 | Pages: 88-94

10.1002/eat.23000 Get It

AbstractObjectiveGiven that weight gain patterns in adolescents receiving outpatient Family‐Based Treatment (FBT) have not been characterized, the purpose of this study was to examine trajectories of weight gain in a group of adolescent patients with a restrictive eating disorder [e.g., anorexia nervosa (AN) and atypical AN] receiving FBT. This study also examined the association of patient characteristics with weight gain trajectories, including age, diagnosis, weight suppression, presenting BMI‐for‐age percentile, and eating pathology.MethodLatent growth mixture modeling was used to identify distinct weight trajectories, as defined by change in BMI‐for‐age percentile, for 153 adolescents with AN or atypical AN, receiving FBT.ResultsThere were five distinct weight gain trajectory profiles for adolescents receiving FBT for a restrictive eating disorder. Younger age and greater weight suppression were associated with more rapid weight gain trajectories. A pattern of slow and consistent weight gain was associated with older age and less eating pathology.DiscussionThere was considerable variability in weight gain trajectories in youth receiving outpatient FBT for a restrictive eating disorder. This suggests that patients' presenting information can be used to inform expectations regarding weight gain trajectories.