McCrady-Spitzer, Shelly K
Mayo Clinic
Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, United States.
Citations 2
The Sixth Annual Symposium of the Midwest Aging Consortium
Sturmlechner, Ines , Ashiqueali, Sarah , Martini, Hélène , Valdivieso, Karla , Franco, Ana Catarina , Guthikonda, Prashanth Kumar, Dosch, Andrew J. , Prieto, Luis I. , Asmussen, Niels C. , Latham, Amanda S. , Redden, James T, Leitschuh, Ethan A , Mashek, Douglas G. , Rodriguez-Lopez, Jhonny , Bernlohr, David , Knopf, Bailey A. , Lamming, Dudley W. , Johnston, Matthew J, Brown-Borg, Holly M., Tye, Spencer A, Rhoads, Timothy W. , Childs, Bennett G. , Li, Xinna, Jang, In Hwa, Camell, Christina D. , Miller, Zachary, Phatnani, Hemali , Haak, Andrew J. , Vanegas-Avendaño, Natalia, Akula, Ramya N, Limkar, Ajinkya R. , Leiser, Scott F, Correia, Jacinta , Bai, Hua, Olszewski, Szczepan, Seldeen, Kenneth L. , Budinger, G R Scott, Morales-Nebreda, Luisa C, Winter, Deborah R. , Spitzer, Shelly K McCrady, Rojas, Mauricio , Schafer, Marissa , Ashiqueali, Sarah A , Guthikonda, Prashanth, Rodriguez-Lopez, Jhonny , Monroe, T Blake , Bernlohr, David A , Lamming, Dudley W , Brown-Borg, Holly M , Rhoads, Timothy W , Gate, David M , Baker, Darren J , Li, Xinna , Miller, Zachary , Phatnani, Hemali , Konopka, Adam R , Limkar, Ajinkya R , Correia, Jacinta , Bai, Hua , Olszewski, Szczepan , Seldeen, Kenneth L , Morales-Nebreda, Luisa C , Winter, Deborah R , McCrady-Spitzer, Shelly K , Anderson, Rozalyn M , LeBrasseur, Nathan K , Schafer, Marissa J , Sturmlechner, Ines , Redden, James T., Passos, João F. , Robbins, Paul D. , Brown‐Borg, Holly M. , Tye, Spencer, Baker, Darren J. , Jang, In Hwa , Konopka, Adam R. , Ricke, William A. , Leiser, Scott F. , Morales‐Nebreda, Luisa , Anderson, Rozalyn M. , Mihaylova, Maria M. , Mora, Ana Lucia , LeBrasseur, Nathan K.
The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences | December 23, 2025 | Volume: 81 | Issue: 3 | Pages: No page available
Abstract Geroscience research benefits from interdisciplinary approaches, team science, and collaborations, which collectively facilitate the discovery of aging mechanisms and their translation into tangible, clinical interventions. Since its inception in 2019, the Midwest Aging Consortium (MAC) has provided an engaging platform for aging researchers in the United States’ Midwest to connect, collaborate, and exchange ideas. The Sixth Annual Research Symposium of the MAC held at the Mayo Clinic in Rochester, Minnesota, in April 2025 highlighted the continued impact of the MAC in bringing together aging researchers, including many trainees and early career investigators, into a collaborative environment. This record-setting event featured interdisciplinary research on key aging mechanisms, including lipid metabolism, mitochondrial dysfunction, stress response, cellular senescence, and immune adaptations across organ systems. New therapeutic concepts and clinical trial approaches were presented. Cutting-edge methodologies including single-cell and spatial transcriptomics, metabolomics, and organoid cultures, to dissect aging process in tissue-specific and systemic contexts also were presented. Overall, the MAC symposium underscored the translational potential of geroscience and reinforced the MAC’s mission to accelerate aging research through regional collaborations and innovation.
Resting Metabolic Rate, Total Daily Energy Expenditure, and Metabolic Adaptation 6 Months and 24 Months After Bariatric Surgery
Wolfe, Bruce M. , Schoeller, Dale A. , McCrady-Spitzer, Shelly , Thomas, Diana M. , Sorenson, Chad E., Levine, James A. , McCrady-Spitzer, Shelly K , Sorenson, Chad
Obesity | March 31, 2018 | Volume: 26 | Issue: 5 | Pages: 862-868
Objective Little is known about long‐term metabolic (energy expenditure) adaptation after bariatric surgery. Methods Resting metabolic rate under basal conditions (RMR), total daily energy expenditure (TDEE), and body composition were measured in 25 participants in the Longitudinal Assessment of Bariatric Surgery‐2. Results Six months after surgery, BMI (±SD) decreased (47 ± 6 kg/m 2 to 37 ± 5 kg/m 2 ), body fat went from 48% ± 6% to 40% ± 6% fat, and fat‐free mass went from 67 ± 9 kg to 60 ± 9 kg. In absolute terms, RMR and TDEE both decreased significantly (1,730 ± 278 kcal/d vs. 1,430 ± 200 kcal/d and 2,879 ± 544 kcal/d vs. 2,369 ± 304 kcal/d), and the achieved energy balance was −1,293 ± 355 kcal/d. Sixteen of these participants underwent repeated measures at ∼24 months; TDEE decreased 6 months postoperatively (2,957 ± 540 kcal/d to 2,423 ± 324 kcal/d; P = 0.0003), but at ∼24 months, TDEE (2,602 ± 471 kcal/d) was not significantly different compared with month 6. The average negative energy balance from baseline to month 24 was −379 ± 131 kcal/d. Conclusions RMR and TDEE fall precipitously in the first 6 months after bariatric surgery, but these adaptive changes were no longer significant after 2 years.