Citations 2
The Sixth Annual Symposium of the Midwest Aging Consortium
Sturmlechner, Ines , Ashiqueali, Sarah , Martini, Hélène , Valdivieso, Karla , Franco, Ana Catarina , Guthikonda, Prashanth Kumar, Dosch, Andrew J. , Prieto, Luis I. , Asmussen, Niels C. , Latham, Amanda S. , Redden, James T, Leitschuh, Ethan A , Mashek, Douglas G. , Rodriguez-Lopez, Jhonny , Bernlohr, David , Knopf, Bailey A. , Lamming, Dudley W. , Johnston, Matthew J, Brown-Borg, Holly M., Tye, Spencer A, Rhoads, Timothy W. , Childs, Bennett G. , Li, Xinna, Jang, In Hwa, Camell, Christina D. , Miller, Zachary, Phatnani, Hemali , Haak, Andrew J. , Vanegas-Avendaño, Natalia, Akula, Ramya N, Limkar, Ajinkya R. , Leiser, Scott F, Correia, Jacinta , Bai, Hua, Olszewski, Szczepan, Seldeen, Kenneth L. , Budinger, G R Scott, Morales-Nebreda, Luisa C, Winter, Deborah R. , Spitzer, Shelly K McCrady, Rojas, Mauricio , Schafer, Marissa , Ashiqueali, Sarah A , Guthikonda, Prashanth, Rodriguez-Lopez, Jhonny , Monroe, T Blake , Bernlohr, David A , Lamming, Dudley W , Brown-Borg, Holly M , Rhoads, Timothy W , Gate, David M , Baker, Darren J , Li, Xinna , Miller, Zachary , Phatnani, Hemali , Konopka, Adam R , Limkar, Ajinkya R , Correia, Jacinta , Bai, Hua , Olszewski, Szczepan , Seldeen, Kenneth L , Morales-Nebreda, Luisa C , Winter, Deborah R , McCrady-Spitzer, Shelly K , Anderson, Rozalyn M , LeBrasseur, Nathan K , Schafer, Marissa J , Sturmlechner, Ines , Redden, James T., Passos, João F. , Robbins, Paul D. , Brown‐Borg, Holly M. , Tye, Spencer, Baker, Darren J. , Jang, In Hwa , Konopka, Adam R. , Ricke, William A. , Leiser, Scott F. , Morales‐Nebreda, Luisa , Anderson, Rozalyn M. , Mihaylova, Maria M. , Mora, Ana Lucia , LeBrasseur, Nathan K.
The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences | December 23, 2025 | Volume: 81 | Issue: 3 | Pages: No page available
Abstract Geroscience research benefits from interdisciplinary approaches, team science, and collaborations, which collectively facilitate the discovery of aging mechanisms and their translation into tangible, clinical interventions. Since its inception in 2019, the Midwest Aging Consortium (MAC) has provided an engaging platform for aging researchers in the United States’ Midwest to connect, collaborate, and exchange ideas. The Sixth Annual Research Symposium of the MAC held at the Mayo Clinic in Rochester, Minnesota, in April 2025 highlighted the continued impact of the MAC in bringing together aging researchers, including many trainees and early career investigators, into a collaborative environment. This record-setting event featured interdisciplinary research on key aging mechanisms, including lipid metabolism, mitochondrial dysfunction, stress response, cellular senescence, and immune adaptations across organ systems. New therapeutic concepts and clinical trial approaches were presented. Cutting-edge methodologies including single-cell and spatial transcriptomics, metabolomics, and organoid cultures, to dissect aging process in tissue-specific and systemic contexts also were presented. Overall, the MAC symposium underscored the translational potential of geroscience and reinforced the MAC’s mission to accelerate aging research through regional collaborations and innovation.
TFAM-dependent mitochondrial integrity in regulatory T cells preserves immune landscape and restrains inflammaging
Guo, Kai , Gill, Jappreet Singh, Debnath, Trishna , Bansal, Benu, Poojary, Rayansh, Correa, Jacquiline Kim, Celik, Hakan, Mehta, Het, Abrham, Eden, Even, Zachery, Rahman, Mansib, Costa, Abby Lund Da , Jain, Shilpi , Murugaiyan, Gopal , Ting, Adrian T. , Hur, Junguk , Brown‐Borg, Holly M. , Jurivich, Donald A. , Mathur, Ramkumar , Wang, Zhihan , Gill, Jappreet Singh, Bansal, Benu, Poojary, Rayansh, Correa, Jacquiline Kim, Celik, Hakan, Rahman, Mansib, Wang, Xusheng , Khan, Nadeem
No container title available | March 9, 2022 | Volume: No volume available | Issue: No issue available | Pages: No page available
Abstract Foxp3⁺ regulatory T cells (Tregs) maintain immune homeostasis, yet the process that preserves their stability during aging remain unclear. Mechanistic progress has been hindered by models that ablate Tregs or delete Foxp3 , which induce acute autoimmunity and prevent longitudinal study of physiological regulatory drift. Here, we establish a dose-dependent mitochondrial framework that preserves Treg lineage survival while permitting gradual metabolic attenuation. Using Treg-restricted TFAM modulation, a complementary haploinsufficient model, and whole-spleen single-cell profiling. We identify lineage-selective immune remodeling characterized by contraction of naïve CD8⁺ and follicular B-cell pools, alteration of CD4⁺ states, expansion of activated Tregs, and emergence of neuroimmune stress linked transcriptional modules that parallel physiological aging. Mechanistically, mitochondrial insufficiency is associated with functional loss of FOXP3- centered chromatin coordination and enrichment of NF-κB/NFAT/AP-1 inflammatory and senescence programs while lineage identity remains detectable. Partial mitochondrial attenuation within Tregs alone is sufficient to drive chronic low-grade systemic inflammation, neuromuscular decline, gut microbial restructuring, and elevated microglial responsiveness without Treg depletion. Pharmacologic and microbiota-directed interventions partially reduce inflammatory tone and improve functional metrics. Together, our findings identify TFAM as a key regulator of immune aging and reveal that healthy mitochondrial function in Tregs is essential for protecting against inflammaging and age-associated functional decline.