Citations 1
Validation of the Semi-Quantitative MRI (SQ-MRI) Score as a Biomarker for Non-Calcific Chronic Pancreatitis in a Multicenter Cohort
Tirkes, Temel, Chang, Stephanie T., Mawad, Kareem , Shah, Zarine K. , Venkatesh, Sudhakar K., Wachsman, Ashley, Li, Liang, Li, Shuang, Easler, Jeffrey, Fogel, Evan L. , Forsmark, Christopher E. , Hart, Phil A., Pandol, Stephen J., Park, Walter G., Topazian, Mark, Trikudanathan, Guru, Vege, Santhi Swaroop, Conwell, Darwin L., Yadav, Dhiraj, Tirkes, Temel , Dasyam, Anil K. , Spilseth, Benjamin , Takahashi, Naoki , Venkatesh, Sudhakar K. , Easler, Jeffrey J. , Forsmark, Chris E. , Hart, Phil A. , Pandol, Stephen J , Park, Walter G., Trikudanathan, Guru , Van Den Eeden, Stephen K , Vege, Santhi Swaroop , Conwell, Darwin L. , Yadav, Dhiraj
No container title available | August 18, 2026 | Volume: No volume available | Issue: No issue available | Pages: No page available
Abstract Purpose Validate the semiquantitative (SQ)-MRI score for chronic pancreatitis (CP) diagnosis in an independent, multicenter cohort. Methods We analyzed MRIs performed at baseline in 337 participants with acute (AP) or recurrent AP (RAP) and 67 with non-calcific chronic pancreatitis (NCCP) enrolled in the PROCEED study from 6/2017 to 3/2023. MRIs were performed at multiple clinical centers using site-specific clinical protocols and a variety of MRI vendors to evaluate the SQ-MRI score in a real-world setting. The SQ-MRI score was calculated using the T1 signal intensity ratio of the pancreas to the spleen (T1 score), arteriovenous enhancement ratio (AVR), and pancreatic body diameter (PBD). We adjusted for confounding by participant characteristics via propensity score weighting. Results Median AVR was higher in AP/RAP (1.18, IQR: 0.97–1.44) than in the NCCP group (1.03, IQR: 0.78–1.22, p = 0.007). Pancreatic body diameters were larger in AP/RAP than in the NCCP group − 7–14 mm (10% vs 25%), 14–20 mm (40% vs 54%), and > 20 mm (50% vs 21%), respectively ( p < 0.01). Median T1 score was higher in AP/RAP (1.18, IQR: 0.96–1.40) than in the NCCP group (1.04, IQR: 0.86–1.32, p = 0.10). Median SQ-MRI score in the AP/RAP group was significantly lower, 1.91 (IQR: 0.97, 2.95), than in the NCCP group, 2.74 (IQR: 2.04–4.03) ( p < 0.001). The propensity score-adjusted AUC for SQ-MRI to distinguish AP/RAP from NCCP was 0.64, which was higher than for individual parameters. Conclusion We have validated the SQ-MRI score in a multicenter cohort using an independent, real-world MRI dataset.