Citations 3
Global burden of HBV-related liver disease: Primary liver cancer due to chronic HBV infection increased in over one-third of countries globally from 2000 to 2021
Danpanichkul, Pojsakorn , Chen, Vincent , Saokhieo, Preenapun , Dejvajara, Disatorn , Sukphutanan, Banthoon , Lopimpisuth, Chawin , Pang, Yanfang , Fallon, Michael B. , Kim, Donghee , Yang, Ju Dong , Aqel, Bashar , Chen, V L , Saokhieo, Preenapun , Huang, Daniel Q , Kim, Donghee , Singal, Amit , Yang, Ju Dong , Aqel, Bashar A. , Terrault, Norah , Wijarnpreecha, Karn , Danpanichkul, Pojsakorn , Duangsonk, Kwanjit , Aboona, Majd B. , Ibrahim, Andrew , Huang, Daniel Q. , Singal, Amit G. , Terrault, Norah A. , Wijarnpreecha, Karn
Hepatology | February 12, 2025 | Volume: 82 | Issue: 5 | Pages: 1274-1286
Backgrounds and Aims: HBV-related liver disease ranks as the seventh leading cause of mortality. Despite advances in prevention and treatment, global disparities in the burden of primary liver cancer (PLC) persist. We evaluate global trends in the prevalence, incidence, and death of HBV-related liver disease. Approach and Results: Data from the Global Burden of Disease Study 2021 evaluated acute HBV infection, HBV-related cirrhosis, and HBV-related liver cancer prevalence, incidence, and death. In 2021, there were 7.30 million cases of acute HBV, 283.64 million cases of HBV-related cirrhosis, and 288,110 cases of HBV-related PLC. HBV-related PLC accounted for 39% of the global incidence of PLC; Western Pacific had the highest rates for HBV-related PLC, with an incidence of 5.24 and a death rate of 4.38 per 100,000 population. Between 2000 and 2021, age-standardized incidence, prevalence, and death rates from HBV-related liver disease decreased; however, the incidence of HBV-related PLC rose in 65 countries from 2000 to 2021. In parallel, age-standardized prevalent rates from HBV-related PLC increased in Europe (annual percent change: 0.77%, 95% CI: 0.72%–0.81%) and the Americas (annual percent change: 1.05%, 95% CI: 1.00%–1.10%). Conclusions: From 2000 to 2021, decreases in HBV-related liver disease incidence and prevalence were observed; however, more than one-third of countries showed an increase in the incidence of HBV-related PLC. These findings highlight the need for strengthened HBV treatment efforts to reduce the risk of liver cancer.
Clostridioides difficile Infection in the Elderly: Trend Analysis from 2000 to 2019
Danpanichkul, Pojsakorn , Uawithya, Ekdanai , Kongarin, Siwanart , Polpichai, Natchaya , Suenghataiphorn, Thanathip , Wattanachayakul, Phuuwadith , Pang, Yanfang , Sukphutanan, Banthoon , Kaewdech, Apichat , Panpradist, Nuttada , Chaiyakunapruk, Nathorn , Pupaibool, Jakrapun , Wijarnpreecha, Karn , Uawithya, Ekdanai , Polpichai, Natchaya , Suenghataiphorn, Thanathip , Kaewdech, Apichat , Panpradist, Nuttada , Chaiyakunapruk, Nathorn , Pupaibool, Jakrapun , Wijarnpreecha, Karn , Danpanichkul, Pojsakorn , Duangsonk, Kwanjit , Simadibrata, Daniel Martin , Pang, Yanfang
Journal of Clinical Medicine | June 26, 2024 | Volume: 13 | Issue: 13 | Pages: 3740
Background/Objective: Clostridioides difficile infection (CDI) is a common healthcare-associated ailment, presenting major health and economic challenges, especially for the elderly. Despite its prevalence, comprehensive data about CDI’s impact on the elderly are limited. Methods: This study used the Global Burden of Disease Study 2019 data to analyze CDI trends from 2000 to 2019, considering factors like sex, region, and sociodemographic index (SDI). Results: This study revealed that CDI caused approximately 18,181 deaths and 252,709 disability-adjusted life years (DALYs) among the elderly worldwide. The Americas showed the highest CDI burden, while the Eastern Mediterranean saw the steepest rate increase from 2000 to 2019. Regions with a high SDI also displayed substantial CDI impact. Conclusions: The escalating burden of CDI in the elderly, especially in high-SDI areas and the Americas, emphasizes an urgent need for targeted public health strategies.
The Burden of Overweight and Obesity-Associated Gastrointestinal Cancers in Low and Lower-Middle-Income Countries: A Global Burden of Disease 2019 Analysis
Danpanichkul, Pojsakorn , Auttapracha, Thanida , Sukphutanan, Banthoon , Ng, Cheng Han , Wattanachayakul, Phuuwadith , Kongarin, Siwanart , Dutta, Priyata , Duangsonk, Kwanjit , Thongpiya, Jerapas , Seko, Yuya , Noureddin, Mazen , Yang, Ju Dong , Wallace, Michael B. , Muthiah, Mark D , Seko, Yuya , Takahashi, Hirokazu , Yang, Ju Dong , Wijarnpreecha, Karn , Wallace, Michael B , Ng, Cheng Han , Danpanichkul, Pojsakorn , Huang, Daniel Q. , Lui, Rashid , Wijarnpreecha, Karn
American Journal of Gastroenterology | April 22, 2024 | Volume: 119 | Issue: 6 | Pages: 1177-1180
INTRODUCTION: Obesity is associated with cancer, including gastrointestinal (GI). Data from low (LICs) and lower-middle-income countries (MICs) are limited. METHODS: We utilized data from the Global Burden of Disease Study 2019 to determine the mortality from GI cancer risk of high body mass index (BMI) in these countries. RESULTS: Mortality rates of GI cancers from high BMI increased in LICs and lower MICs, while burdens decreased or remained stable in high and middle-income countries. DISCUSSION: The GI cancer-related burden from high BMI increased in LICs and lower MICs, necessitating a concerted effort to tackle the obesity pandemic.