Malik, Rayaz A.
https://orcid.org/0000-0002-7188-8903
Mayo Clinic
Institut für Schlaganfall- und Demenzforschung
Citations 2
Low density lipoprotein receptor related protein 1 and 6 gene variants and ischaemic stroke risk
Harriott, Andrea M. , Rayaprolu, Sruti , Soto‐Ortolaza, Alexandra I., Diehl, Nancy N. , Kanekiyo, Takahisa , Bu, Guojun , Malik, Rayaz A. , Ross, Owen A. , Soto‐Beasley, Alexandra I. , Heckman, Michael G. , Liu, Chin‐Chi , Cole, John W. , Meschia, James F. , Ross, Owen A , Bu, Guojun , Beasley, Alexandra I
European Journal of Neurology | May 29, 2015 | Volume: 22 | Issue: 8 | Pages: 1235-1241
Background and purposeLow density lipoprotein receptor related proteins (LRPs) 1 and 6 have been implicated in cerebral ischaemia. In addition, genetic variation in LRP1 and LRP6 has been linked with various factors that are related to risk of ischaemic stroke. The aim of this study was to examine the association of LRP1 and LRP6 gene variants with risk of ischaemic stroke as part of the Ischemic Stroke Genetics Study (ISGS).MethodsA Caucasian series (434 stroke patients, 319 controls) and an African American series (161 stroke patients, 116 controls) were included. Fourteen LRP6 variants and three LRP1 variants were genotyped and assessed for association with ischaemic stroke.ResultsIn the Caucasian series, significant associations with ischaemic stroke were observed for LRP6 rs2075241 [odds ratio (OR) 0.42, P = 0.023], rs2302685 (OR 0.44, P = 0.049), rs7975614 (OR 0.07, P = 0.017), rs10492120 (OR 0.62, P = 0.036) and rs10743980 (OR 0.66, P = 0.037). Risk of ischaemic stroke was significantly lower for carriers of any of these five protective LRP6 variants (24.0% of subjects) compared to non‐carriers (OR 0.57, P = 0.003). The protective association for LRP6 rs2075241 was observed at a similar magnitude across ischaemic stroke subtypes, whilst the effects of rs23022685, rs10492120 and rs10743980 were most apparent for cardioembolic and large vessel stroke. In the African American series, LRP1 rs11172113 was associated with an increased risk of stroke (OR 1.89, P = 0.006).ConclusionsThe results of our preliminary study provide evidence that LRP6 and LRP1 variants may be associated with risk of ischaemic stroke. Validation in larger studies is warranted.
Diabetic Neuropathies: Update on Definitions, Diagnostic Criteria, Estimation of Severity, and Treatments
Tesfaye, Solomon , Dyck, Peter James , Kempler, Péter , Lauria, Giuseppe , Malik, Rayaz A. , Spallone, Vincenza , Vinik, Aaron I. , Bernardi, Luciano, Valensi, Paul, Group, on behalf of the Toronto Diabetic Neuropathy Expert, Feldman, Eva L. , Pop‐Busui, Rodica , Boulton, Andrew J.M. , Freeman, Roy L. , Horowitz, Michael , Group, on behalf of the Toronto Diabetic Neuropathy Expert, Pop-Busui, Rodica , Feldman, Eva L
Diabetes Care | September 28, 2010 | Volume: 33 | Issue: 10 | Pages: 2285-2293
Preceding the joint meeting of the 19th annual Diabetic Neuropathy Study Group of the European Association for the Study of Diabetes (NEURODIAB) and the 8th International Symposium on Diabetic Neuropathy in Toronto, Canada, 13–18 October 2009, expert panels were convened to provide updates on classification, definitions, diagnostic criteria, and treatments of diabetic peripheral neuropathies (DPNs), autonomic neuropathy, painful DPNs, and structural alterations in DPNs.