Citations 2
Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease
Rae, Rosaria J., Alberhasky, Jessica Marie Hunter, Bangasser, Debra A. , Berteotti, Chiara, Bow, Hannah, Caldwell, Jessica Z. K., Carpi, Matteo , Ciampa, Claire J., Ehrenberg, Alexander J. , Fenlon, Haley A., Fitzhugh, Megan C. , Gallay, Clara , Hamilton, Derek A. , Hasan, Zia , Huarte, Oihane Uriarte , Jabeen, Shaista , Kolling, Louis John , Liguori, Claudio , Omoluabi, Tamunotonye, Pa, Judy, Pentkowski, Nathan S. , Pereira, Joana B., Ramos, Rhudovic R., Sargin, Derya , Seto, Mabel, Shaik, Shabana M. , Ucheagwu, Valentine , Kelberman, Michael A. , Grinberg, Lea Tenenholz, Satpati, Abhijit, Son, Gowoon, Rae, Rosaria Josephine, Baillet, Marion , Belloy, Michaël E. , Berry, Anne S. , Berteotti, Chiara , Bow, Hannah, Buckley, Rachel F. , Caldwell, Jessica K. , Clark, Benjamin J. , Conley, Alexander C. , Dahl, Martin J. , Donaldson, Zoe R. , Einstein, Gillian , Falgàs, Neus , Froemke, Robert C. , Grinberg, Lea T. , Jacobs, Heidi I.L. , Koops, Elouise A. , Lenzoni, Sabrina , Manca, Riccardo , Marcinkiewcz, Catherine Anne , Omoluabi, Tamunotonye, Oria, Rademene Sunday , Orsini, Caitlin A. , Ortega, Nancy Elizabeth , Pa, Judy , Pereira, Joana B. , Satpati, Abhijit , Sellés, María Clara , Seto, Mabel , Sindi, Shireen , Son, Gowoon , Egroo, Maxime Van , Yuan, Qi
Alzheimer's & Dementia | March 19, 2026 | Volume: 22 | Issue: 3 | Pages: No page available
Abstract Neuromodulatory subcortical systems (NSSs) are uniquely susceptible to dementia‐related pathology, leading to frequent molecular and behavioral impairments associated with altered function of these nuclei. Some of these systems display clear sex‐specific cytoarchitecture and signaling leading to distinct physiology and behavioral outputs in males and females, while other regions display nominal sex differences. However, the relevance of sex differences in modulating dysfunction of NSSs in Alzheimer's disease (AD) and related dementias is not well understood. This review is a joint effort by the Neuromodulatory Subcortical Systems and Sex and Gender Differences in Alzheimer's Disease Professional Interest Areas of the Alzheimer's Association. We review sex differences in NSSs, both in non‐disease states and in AD models and patients. We highlight the possible role of NSSs in driving sex‐specific AD susceptibility and potential footholds for sex‐based interventions targeting these systems. We conclude by outlining immediate and long‐term actions to address the intersection of NSSs, sex, and AD.
Subjective Sleep Quality as it Relates to Cognitive and Physical Function in Spinal Muscular Atrophy Patients
Lenzoni, Sabrina , Turcano, Pierpaolo , Casagrande, Elena, Caumo, Luca, Sorarú, Gianni , Pegoraro, Elena , Semenza, Carlo , Wennberg, Alexandra , Casagrande, Elena
Journal of Neuromuscular Diseases | May 10, 2023 | Volume: 10 | Issue: 4 | Pages: 713-717
Sleep quality and its association with cognition has been widely studied in some neurodegenerative diseases, but less is known about this association in spinal muscular atrophy (SMA). In adult SMA ( n = 21) patients and age-matched controls ( n = 23), we assessed subjectively measured sleep quality and daytime somnolence. Cognition was assessed with a multi-domain neuropsychological battery. Further, we investigated the association between clinical functional scores and sleep questionnaire scores. Among SMA patients, better motor and limb function was associated with better subjective sleep quality ( p’s< 0.05). Clinicians should consider sleep quality in patient care and future studies are needed to better understand these relationships.