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Saykin, Andrew J.

https://orcid.org/0000-0002-1376-8532

Mayo Clinic

Indiana University School of Medicine

Citations 138

P3‐017: ASSOCIATION ANALYSIS OF RARE VARIANTS NEAR THE APOE REGION WITH CEREBROSPINAL FLUID (CSF) BIOMARKERS OF ALZHEIMER'S DISEASE
Foroud, Tatiana M., Shaw, Leslie M. , Trojanowski, John Q. , Aisen, Paul, Petersen, Ronald , Weiner, Michael W. , Nho, Kwangsik T. , Kim, Sungeun , Risacher, Shannon L. , Shen, Li , Jack, Clifford R. , Green, Robert C. , Toga, Arthur W. , Saykin, Andrew J.

Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_17 | Pages: No page available

10.1016/j.jalz.2014.05.1104 Get It

IC‐P‐174: RARE VARIANT IN PLD3 IS ASSOCIATED WITH ALZHEIMER'S PATTERN OF NEURODEGENERATIVE CHANGES
Aisen, Paul, Petersen, Ronald C. , Weiner, Michael W. , Nho, Kwangsik T. , Kim, Sungeun , Risacher, Shannon L. , Shen, Li , Foroud, Tatiana , Jack, Clifford R. , Green, Robert C. , Toga, Arthur W. , Saykin, Andrew J.

Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_7 | Pages: No page available

10.1016/j.jalz.2014.05.181 Get It

IC‐P‐095: TWO‐YEAR LONGITUDINAL CHANGE IN AMYLOID DEPOSITION, GLUCOSE METABOLISM, AND HIPPOCAMPAL ATROPHY IN ADNI‐2 PARTICIPANTS: RELATION TO GENETIC RISK
Kim, Sungeun , West, John D. , Petersen, Ronald C. , Aisen, Paul , Jagust, William J. , Weiner, Michael W. , Risacher, Shannon L. , Nho, Kwangsik T. , Jack, Clifford R. , Koeppe, Robert A. , Saykin, Andrew J.

Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_6 | Pages: No page available

10.1016/j.jalz.2014.05.100 Get It

P3‐018: INFLUENCE OF RARE PSEN1 VARIANTS ON QUANTITATIVE STRUCTURAL IMAGING AND CSF PHENOTYPES IN LATE ONSET ALZHEIMER'S DISEASE
Aisen, Paul, Petersen, Ronald , Shaw, Leslie M. , Trojanowski, John Q., Weiner, Michael W. , Nho, Kwangsik T. , Kim, Sungeun , Risacher, Shannon L. , Shen, Li , Foroud, Tatiana , Jack, Clifford R. , Trojanowski, John Q., Green, Robert C. , Toga, Arthur W. , Saykin, Andrew J.

Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_17 | Pages: No page available

10.1016/j.jalz.2014.05.1105 Get It

O2‐03‐03: BIN1 AND CR1 VARIANTS AFFECT COGNITIVE PERFORMANCE, NEURODEGENERATION, AND BRAIN AMYLOIDOSIS IN ADNI SUBJECTS
Blanken, Anna E., Torosyan, Nare , Manne, Manogna, Durcanova, Beata, Apostolova, Liana G. , Silverman, Daniel H.S. , Saykin, Andrew J. , Jack, Clifford R.

Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_2 | Pages: No page available

10.1016/j.jalz.2014.04.169 Get It

IC‐P‐106: LONGITUDINAL RATES OF ATROPHY IN FAMILIAL ALZHEIMER'S DISEASE
Leung, Kelvin K., Ahsan, Laila, Nicholas, Jennifer M. , Malone, Ian B. , Sperling, Reisa R., Villemagne, Victor L. , Weiner, Michael W. , Marcus, Daniel C. , Cash, David M. , Kinnunen, Kirsi M. , Cardoso, M. Jorge , Modat, Marc , Benzinger, Tammie L.S. , Jack, Clifford R. , Thompson, Paul M. , Saykin, Andrew J. , Sperling, Reisa, Bateman, Randall J. , Morris, John C. , Rossor, Martin N. , Ourselin, Sébastien , Fox, Nick C.

Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_6 | Pages: No page available

10.1016/j.jalz.2014.05.112 Get It

IC‐P‐096: INCREASED AMYLOID DEPOSITION IN OLDER ADULTS AT RISK FOR PROGRESSION TO ALZHEIMER'S DISEASE DUE TO GENETIC BACKGROUND AND/OR THE PRESENCE OF SIGNIFICANT MEMORY CONCERNS
Kim, Sungeun , West, John D. , Petersen, Ronald C. , Aisen, Paul , Jagust, William J. , Weiner, Michael W. , Risacher, Shannon L. , Nho, Kwangsik T. , Wang, Yang , Jack, Clifford R. , Koeppe, Robert A. , Saykin, Andrew J.

Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_6 | Pages: No page available

10.1016/j.jalz.2014.05.101 Get It

O3‐03‐02: TWO‐YEAR LONGITUDINAL CHANGE IN AMYLOID DEPOSITION, GLUCOSE METABOLISM, AND HIPPOCAMPAL ATROPHY IN ADNI‐2 PARTICIPANTS: RELATION TO GENETIC RISK
Kim, Sungeun , West, John D. , Petersen, Ronald C. , Aisen, Paul , Jagust, William J. , Koeppe, Robert, Weiner, Michael W. , Risacher, Shannon L. , Nho, Kwangsik T. , Jack, Clifford R. , Saykin, Andrew J.

Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_3 | Pages: No page available

10.1016/j.jalz.2014.04.281 Get It

P3‐024: NEXT‐GENERATION SEQUENCING OF THE BCHE LOCUS IDENTIFIES A FUNCTIONAL SNP ASSOCIATED WITH ALZHEIMER'S DISEASE BIOMARKERS AND AGE OF ONSET
Kim, Sungeun , Aisen, Paul, Huentelman, Matthew J. , Jagust, William J. , Petersen, Ronald Carl, Shaw, Leslie M. , Trojanowski, John Q. , Weiner, Michael W. , Ramanan, Vijay K. , Nho, Kwangsik T. , Risacher, Shannon L. , Shen, Li , Swaminathan, Shanker , Foroud, Tatiana , Håkonarson, Håkon , Jack, Clifford R. , Potkin, Steven G. , Green, Robert C. , Toga, Arthur W. , Saykin, Andrew J.

Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_17 | Pages: No page available

10.1016/j.jalz.2014.05.1111 Get It

Effects of traumatic brain injury and posttraumatic stress disorder on Alzheimer's disease in veterans, using the Alzheimer's Disease Neuroimaging Initiative
Weiner, Michael W. , Veitch, Dallas P. , Aisen, Paul, Petersen, Ronald C. , Jagust, William, Trojanowski, John Q. , Shaw, Leslie M. , Saykin, Andrew J. , Harvey, Danielle , Pacifico, Anthony, Sheline, Yvette I. , Yaffe, Kristine , Mohlenoff, Brian, Hayes, Jacqueline , Neylan, Thomas C. , Grafman, Jordan Henry , Jack, Clifford R. , Green, Robert C. , Toga, Arthur W. , Friedl, Karl E. , Saykin, Andrew J , Harvey, Danielle J

Alzheimer's & Dementia | June 9, 2014 | Volume: 10 | Issue: 3S | Pages: No page available

10.1016/j.jalz.2014.04.005 Get It

AbstractBoth traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) are common problems resulting from military service, and both have been associated with increased risk of cognitive decline and dementia resulting from Alzheimer's disease (AD) or other causes. This study aims to use imaging techniques and biomarker analysis to determine whether traumatic brain injury (TBI) and/or PTSD resulting from combat or other traumas increase the risk for AD and decrease cognitive reserve in Veteran subjects, after accounting for age. Using military and Department of Veterans Affairs records, 65 Vietnam War veterans with a history of moderate or severe TBI with or without PTSD, 65 with ongoing PTSD without TBI, and 65 control subjects are being enrolled in this study at 19 sites. The study aims to select subject groups that are comparable in age, gender, ethnicity, and education. Subjects with mild cognitive impairment (MCI) or dementia are being excluded. However, a new study just beginning, and similar in size, will study subjects with TBI, subjects with PTSD, and control subjects with MCI. Baseline measurements of cognition, function, blood, and cerebrospinal fluid biomarkers; magnetic resonance images (structural, diffusion tensor, and resting state blood‐level oxygen dependent (BOLD) functional magnetic resonance imaging); and amyloid positron emission tomographic (PET) images with florbetapir are being obtained. One‐year follow‐up measurements will be collected for most of the baseline procedures, with the exception of the lumbar puncture, the PET imaging, and apolipoprotein E genotyping. To date, 19 subjects with TBI only, 46 with PTSD only, and 15 with TBI and PTSD have been recruited and referred to 13 clinics to undergo the study protocol. It is expected that cohorts will be fully recruited by October 2014. This study is a first step toward the design and statistical powering of an AD prevention trial using at‐risk veterans as subjects, and provides the basis for a larger, more comprehensive study of dementia risk factors in veterans.