Back to Authors

Verspoor, F.G.M.

https://orcid.org/0000-0001-8027-5888

Mayo Clinic

Amsterdam University Medical Centers

Citations 2

Identifying consensus and areas for future research in chondrosarcoma
Kurisunkal, Vineet , Botello, Eduardo , Boyle, Richard A. , Ebeid, Walid , Houdek, Matthew T. , Puri, Ajay , Brennan, Bernadette , Laitinen, Minna , Jutte, Paul C. , Lazarides, Alexander L. , Verspoor, F.G.M. , Visgauss, Julia D. , Jeys, Lee M , Morris, Guy V , Kurisunkal, Vineet , Botello, Eduardo , Ebeid, Walid , Houdek, Matthew T , Puri, Ajay , Ruggieri, Pietro , Brennan, Bernadette , Laitinen, Minna K , Couch, Cory , Rose, Peter, Sullivan, Mikaela, Tibbo, Meagan, Jutte, Paul , Visgauss, Julia D , Jeys, Lee , Ruggieri, Pietro

The Bone & Joint Journal | February 1, 2025 | Volume: 107-B | Issue: 2 | Pages: 246-252

10.1302/0301-620x.107b2.bjj-2024-0643.r1 Get It

AimsThe Birmingham Orthopaedic Oncology Meeting (BOOM), held in January 2024, convened 309 delegates from 53 countries to discuss and refine 21 consensus statements on the optimal management of chondrosarcoma.MethodsWith representation from Europe (43%; n = 133), North America (17%; n = 53), South America (16%; n = 49), Asia (13%; n = 40), Australasia (5%; n = 16), the Middle East (4%; n = 12), and Africa (2%; n = 6), the combined experience of treating bone sarcomas among attendees totalled approximately 30,000 cases annually, equivalent to 66 years of experience in the UK alone. The meeting’s process began with the formation of a local organizing committee, regional leads, and a scientific committee comprising representatives from 150 specialist units across 47 countries. Supported by major orthopaedic oncology organizations, the meeting used a modified Delphi process to develop consensus statements through online questionnaires, thematic groupings, narrative reviews, and anonymous pre-meeting polling.ResultsStrong (> 80%) consensus was achieved on 19 out of 21 statements, reflecting agreement among delegates. Key areas of consensus included the role of radiology in diagnosis and surveillance, the management of locally recurrent disease, and the treatment of dedifferentiated chondrosarcoma. Notably, there was agreement that routine chemotherapy has no role in chondrosarcoma treatment, and radiological surveillance is safe for intraosseous chondrosarcomas. Despite the overall consensus, areas of controversy remain, particularly regarding the treatment of atypical cartilage tumours and surgical margins. These unresolved issues underscore the need for further research and collaboration within the orthopaedic oncology community.ConclusionBOOM represents the largest global consensus meeting in orthopaedic oncology, providing valuable guidance for clinicians managing chondrosarcoma worldwide. The consensus statements offer a reference for clinical practice, highlight key research priorities, and aim to improve patient outcomes on a global scale.Cite this article: Bone Joint J 2025;107-B(2):246–252.
One-Stage Synovectomies Result in Improved Short-Term Outcomes Compared to Two-Stage Synovectomies of Diffuse-Type Tenosynovial Giant Cell Tumor (D-TGCT) of the Knee: A Multicenter, Retrospective, Cohort Study
Spierenburg, Geert , Verspoor, F.G.M. , Wunder, Jay S. , Griffin, Anthony M. , Houdek, Matthew T. , King, David M. , Boyle, Richard , Randall, R. Lor , Thorpe, Steven W. , Priester, Jacob , Geiger, Erik J. , Schreuder, Bart, Gelderblom, Hans , Sande, Michiel A. J. van de , Houdek, Matthew T , Randall, Robert Lor , Gelderblom, Hans , van de Sande, Michiel A J , Ferguson, Peter C. , Boyle, Richard, Heijden, Lizz van der , Bernthal, Nicholas M

Cancers | February 2, 2023 | Volume: 15 | Issue: 3 | Pages: 941

10.3390/cancers15030941 Get It

Diffuse-type tenosynovial giant cell tumors’ (D-TGCTs) intra- and extra-articular expansion about the knee often necessitates an anterior and posterior surgical approach to facilitate an extensive synovectomy. There is no consensus on whether two-sided synovectomies should be performed in one or two stages. This retrospective study included 191 D-TGCT patients from nine sarcoma centers worldwide to compare the postoperative short-term outcomes between both treatments. Secondary outcomes were rates of radiological progression and subsequent treatments. Between 2000 and 2020, 117 patients underwent one-stage and 74 patients underwent two-stage synovectomies. The maximum range of motion achieved within one year postoperatively was similar (flexion 123–120°, p = 0.109; extension 0°, p = 0.093). Patients undergoing two-stage synovectomies stayed longer in the hospital (6 vs. 4 days, p < 0.0001). Complications occurred more often after two-stage synovectomies, although this was not statistically different (36% vs. 24%, p = 0.095). Patients treated with two-stage synovectomies exhibited more radiological progression and required subsequent treatments more often than patients treated with one-stage synovectomies (52% vs. 37%, p = 0.036) (54% vs. 34%, p = 0.007). In conclusion, D-TGCT of the knee requiring two-side synovectomies should be treated by one-stage synovectomies if feasible, since patients achieve a similar range of motion, do not have more complications, but stay for a shorter time in the hospital.