Schellenberg, Gerard D.
https://orcid.org/0000-0003-1115-2475
Mayo Clinic
University of Pennsylvania
Citations 21
P1‐059: MAPT haplotypes modify the association between head injury and risk of Alzheimer's disease
Bird, Thomas D., Boeve, Bradley, Schaid, Daniel J. , Taner, Nilüfer, Allen, Mariet , Barral, Sandra, Graff-Radford, N. R., Faber, Kelly, Farlow, Martin R. , Rosenberg, Roger N., Rumbaugh, Malia, Sano, Mary , Schellenberg, Gerard D. , Silverman, Jeremy M. , Mayeux, Richard , Tsuang, Debby W. , Vardarajan, Badri Narayan , Bennett, David A. , Cruchaga, Carlos , Goate, Alison , Foroud, Tatiana , Ottman, Ruth , Sweet, Robert A.
Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_8 | Pages: No page available
P1‐049: Exploiting blood transcriptome for gene and pathway identification in Alzheimer's disease
Allen, Mariet , Wang, Xue , Serie, Daniel, Strickland, Samantha L. , Nguyen, Thuy , Malphrus, Kimberly G., Lincoln, Sarah, Carrasquillo, Minerva M. , Schellenberg, Gerard D. , Lowe, Val J. , Younkin, Steven G. , Asmann, Yan W. , Petersen, Ronald C. , Taner, Nilüfer, Burgess, Jeremy D. , Carrasquillo, Minerva M. , Crook, Julia E. , Knopman, David S. , Jack, Clifford R.
Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_7 | Pages: No page available
P2‐015: Exploring alternative splicing and gene expression of load candidate genes in blood
Allen, Mariet , Kachadoorian, Michaela, Nguyen, Thuy , Malphrus, Kimberly G., Lincoln, Sarah, Carrasquillo, Minerva M. , Schellenberg, Gerard D. , Lowe, Val J. , Younkin, Steven G. , Petersen, Ronald C. , Taner, Nilüfer, Burgess, Jeremy D. , Carrasquillo, Minerva M. , Knopman, David S. , Jack, Clifford R. , Dickson, Dennis W.
Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_10 | Pages: No page available
Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals
Reitz, Christiane , Cheng, Rong , Jun, Gyungah , Sato, Christine , Rajbhandary, Ruchita, Wang, Li San, Lin, Chiao‐Feng , Larson, Eric B., Graff‐Radford, Neill R. , Evans, Denis A., Jager, Philip L. De , Crane, Paul K. , Buxbaum, Joseph D. , Murrell, Jill R. , Raj, Towfique , Ertekin‐Taner, Nilüfer , Logue, Mark, Baldwin, Clinton T., Green, Robert C. , Barnes, Lisa L. , Cantwell, Laura B., Fallin, M. Daniele , Go, Rodney C.P., Griffith, Patrick , Obisesan, Thomas O. , Bennett, David A. , Hendrie, Hugh C. , Hall, Kathleen, Byrd, Goldie S. , Kukull, Walter A. , Foroud, Tatiana M., Haines, Jonathan L. , Farrer, Lindsay A. , Pericak‐Vance, Margaret A. , Schellenberg, Gerard D. , Mayeux, Richard , Morris, John C. , Leverenz, James B. , DeKosky, Steven T. , Håkonarson, Håkon , Jarvik, Gail P. , Albin, Roger L. , Lyketsos, Constantine G. , Jicha, Gregory A. , Demirci, F. Yesim , Burke, James R. , Cao, Chuanhai , Carroll, Steven L. , Cribbs, David H. , Mack, Wendy J. , Sonnen, Joshua A. , Bennett, David A. , Ghani, Mahdi , Vardarajan, Badri Narayan , Naj, Adam Christian , Valladares, Otto , Manly, Jennifer J. , Lunetta, Kathryn L. , Kamboh, M. Ilyas , López, Oscar L. , Goate, Alison , Lee, Joseph H. , George‐Hyslop, Peter St , Rogaeva, Ekaterina A. , Hakonarson, Hakon , Leverenz, James B , Jarvik, Gail P , Morris, John C , Jicha, Gregory A , Sonnen, Joshua , Barnes, Lisa L
JAMA Neurology | September 14, 2015 | Volume: 72 | Issue: 11 | Pages: 1313
Global and local ancestry in African‐Americans: Implications for Alzheimer's disease risk
Hohman, Timothy J. , Bailey, Jessica N. Cooke , Reitz, Christiane , Jun, Gyungah , Beecham, Gary W. , Carney, Regina M., Vance, Jeffery M. , Rajbhandary, Ruchita, Lin, Chiao‐Feng , Larson, Eric B., Graff‐Radford, Neill R. , Evans, Denis A., Jager, Philip L. De , Crane, Paul K. , Buxbaum, Joseph D. , Murrell, Jill R. , Raj, Towfique , Ertekin‐Taner, Nilüfer , Baldwin, Clinton T., Green, Robert C. , Barnes, Lisa L. , Cantwell, Laura B., Fallin, M. Daniele , Go, Rodney C.P., Griffith, Patrick , Obisesan, Thomas O. , Lunetta, Kathryn L. , Kamboh, M. Ilyas , Bennett, David A. , Hardy, John , Hendrie, Hugh C. , Hall, Kathleen, Goate, Alison , Lang, Rosalyn, Byrd, Goldie S. , Kukull, Walter A. , Farrer, Lindsay A. , Martin, Eden R. , Pericak‐Vance, Margaret A. , Schellenberg, Gerard D. , Mayeux, Richard , Haines, Jonathan L. , Thornton‐Wells, Tricia A., Carroll, Steven L. , Bennett, David A. , Naj, Adam Christian , Liu, Zhi , Cuccaro, Michael L. , Vardarajan, Badri Narayan , Wang, Weixin , Valladares, Otto , Logue, Mark W. , Manly, Jennifer J. , López, Oscar L. , Foroud, Tatiana , Seto, Mabel , Hardy, John , Goate, Alison M , Barnes, Lisa L
Alzheimer's & Dementia | June 16, 2015 | Volume: 12 | Issue: 3 | Pages: 233-243
AbstractIntroductionAfrican‐American (AA) individuals have a higher risk for late‐onset Alzheimer's disease (LOAD) than Americans of primarily European ancestry (EA). Recently, the largest genome‐wide association study in AAs to date confirmed that six of the Alzheimer's disease (AD)‐related genetic variants originally discovered in EA cohorts are also risk variants in AA; however, the risk attributable to many of the loci (e.g., APOE, ABCA7) differed substantially from previous studies in EA. There likely are risk variants of higher frequency in AAs that have not been discovered.MethodsWe performed a comprehensive analysis of genetically determined local and global ancestry in AAs with regard to LOAD status.ResultsCompared to controls, LOAD cases showed higher levels of African ancestry, both globally and at several LOAD relevant loci, which explained risk for AD beyond global differences.DiscussionExploratory post hoc analyses highlight regions with greatest differences in ancestry as potential candidate regions for future genetic analyses.
Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans
Schu, Matthew , Farrell, John J. , Bennett, David A. , Buxbaum, Joseph D. , Byrd, Goldie S. , Ertekin‐Taner, Nilüfer , Evans, Denis A., Goate, Alison , Graff‐Radford, Neill R. , Kamboh, M. Ilyas , Kukull, Walter A. , Haines, Jonathan L. , Mayeux, Richard , Pericak‐Vance, Margaret A. , Schellenberg, Gerard D. , Baldwin, Clinton T., Fallin, M. Daniele , Farrer, Lindsay A. , Tsuang, Debby W. , Carroll, Steven L. , Logue, Mark W. , Vardarajan, Badri Narayan , Foroud, Tatiana , Manly, Jennifer J. , Lunetta, Kathryn L. , Bennett, David A. , Goate, Alison M
Alzheimer's & Dementia | August 26, 2014 | Volume: 10 | Issue: 6 | Pages: 609
AbstractBackgroundLess is known about the genetic basis of Alzheimer's disease (AD) in African Americans (AAs) than in non‐Hispanic whites.MethodsWhole exome sequencing (WES) was performed on seven AA AD cases. Disease association with potentially AD‐related variants from WES was assessed in an AA discovery cohort of 422 cases and 394 controls. Replication was sought in an AA sample of 1037 cases and 1869 controls from the Alzheimer Disease Genetics Consortium (ADGC).ResultsForty‐four single nucleotide polymorphisms (SNPs) from WES passed filtering criteria and were successfully genotyped. Nominally significant (P < .05) association to AD was observed with two African‐descent specific AKAP9 SNPs in tight linkage disequilibrium: rs144662445 (P = .014) and rs149979685 (P = .037). These associations were replicated in the ADGC sample (rs144662445: P = .0022, odds ratio [OR] = 2.75; rs149979685: P = .0022, OR = 3.61).ConclusionsBecause AKAP9 was not previously linked to AD risk, this study indicates a potential new disease mechanism.
O5‐03‐03: Genetic association of progressive supranuclear palsy (PSP) risk loci variants with brain gene expression and neuropathology endophenotypes
Ertekin‐Taner, Nilüfer , Allen, Mariet , Murray, Melissa E. , Serie, Daniel, Zou, Fanggeng, Chai, High Seng, Younkin, Curtis, Carrasquillo, Minerva M. , Rowley, Christopher , Nair, Asha, Maharjan, Sooraj, Nguyen, Thuy , Malphrus, Kimberly G., Palusak, Ryan, Lincoln, Sarah, Bisceglio, Gina, Georgescu, Constantin , Kolbert, Christopher P., Jen, Jin , Schellenberg, Gerard D. , Petersen, Ronald C. , Graff‐Radford, Neill R. , Younkin, Steven G. , Crook, Julia E. , Pankratz, V. Shane , Carrasquillo, Minerva M. , Middha, Sumit , Ma, Li , Kouri, Naomi , Dickson, Dennis W. , Murray, Melissa E
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_20 | Pages: No page available
O1‐09‐01: CTNNA3, CAPRIN2 and SPG20 are significantly associated with Alzheimer's disease in preliminary analyses of a genome‐wide association study in African‐Americans
Reitz, Christiane , Hall, Kathleen, Evans, Denis A., Ertekin‐Taner, Nilüfer , Fallin, Danielle, Pericak‐Vance, Margaret A. , Haines, Jonathan L. , Mayeux, Richard , Schellenberg, Gerard D. , Manly, Jennifer J. , Bennett, David A. , Buxbaum, Joseph D. , Kamboh, M. Ilyas , Foroud, Tatiana , Goate, Alison , Farrer, Lindsay A.
Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_3 | Pages: No page available
Novel late-onset Alzheimer disease loci variants associate with brain gene expression
Allen, Mariet , Zou, Fanggeng, Chai, High Seng, Younkin, Curtis, Carrasquillo, Minerva M. , Rowley, Christopher , Nair, Asha, Middha, Sumit , Maharjan, Sooraj, Nguyen, Thuy , Malphrus, Kimberly G., Palusak, Ryan, Lincoln, Sarah, Bisceglio, Gina, Georgescu, Constantin , Schultz, Debra A., Rakhshan, Fariborz, Kolbert, Christopher P., Jen, Jin , Haines, Jonathan L. , Mayeux, Richard , Pericak‐Vance, Margaret A. , Farrer, Lindsay A. , Schellenberg, Gerard D. , Petersen, Ronald C., Graff‐Radford, Neill R. , Dickson, Dennis W. , Younkin, Steven G., Ertekin‐Taner, Nilüfer , Hardy, John , Ferris, Steven H. , DeKosky, Steven T. , Jicha, Gregory A. , Buxbaum, Joseph D. , Jun, Gyungah , Tsuang, Debby W. , Reisberg, Barry , Carroll, Steven L. , Crook, Julia E. , Pankratz, V. Shane , Carrasquillo, Minerva M. , Ma, Li , Dickson, Dennis W , Hardy, John , Jicha, Gregory A
Neurology | June 22, 2012 | Volume: 79 | Issue: 3 | Pages: 221-228
Genotype patterns atPICALM, CR1, BIN1, CLU, andAPOEgenes are associated with episodic memory
Barral, Sandra , Bird, Thomas D., Goate, Alison , Farlow, MR, Diaz‐Arrastia, Ramon , Bennett, David A. , Graff-Radford, N. R., Stern, Yaakov , Ott, Jürg , Mayeux, Richard , Kowall, Neil W. , Williamson, Jennifer, Santana, Vincent, Schmechel, Donald E., Gaskel, Peter, Farlow, Martin R. , Faber, Kelley, Horner, Kelly, Growdon, John H., Blacker, Deborah , Tanzi, Rudolph E. , Kuntz, Karen M. , Norgaard, Lindsay, Larson, Nathan, Kistler, Dana, Parfitt, Francine, Haddow, Jenny, Silverman, Jeremy M. , Beeri, Michal Schnaider , Sano, Mary , Wang, Joy , Lally, Rachel, Johnson, Nancy, Mesulam, Marcel, Weıntraub, Sandra , Bigio, Eileen H. , Kaye, Jeffery, Kramer, Patricia, Payne-Murphy, Jessica, Jacobs, Holli, Chang, Joon, Arends, Danielle, Harrell, Lindy, Bartzokis, George, Cummings, Jeffery L., Lu, Po H. , Toland, Usha, Smith, Charles , Brickhouse, Alise, Trojanowski, John Q. , DeKosky, Steven T. , Weamer, Elise A., Chui, Helena C., Varpetian, Arousiak, Rosenberg, Roger N., Schellenberg, Gerard D. , Raskind, Murray A. , Rumbaugh, Malia, Nickel, Kate, Norton, Joanne, Levitch, Denise, Grant, B., Coats, Mary A., Levey, Allen, Rosen, Ami, Anosike, Ezinna, Bennett, David A. , Wilson, Robert S. , Boeve, Bradley F. , Sweet, Robert A. , Wilson, R. J. , Foroud, Tatiana , Green, Robert C. , Farrer, Lindsay A. , Ghetti, Bernardino , Prentice, Heather A. , Hyman, Bradley T. , Larson, Nathan, Kaye, Jeffery, Deerlin, Vivianna M. Van , Wood, Elisabeth McCarty , Davis, Barbara Allen , Morris, John A. , Stern, Yaakov , Goate, Alison M , Diaz-Arrastia, Ramon
Neurology | April 27, 2012 | Volume: 78 | Issue: 19 | Pages: 1464-1471