Citations 2
Multi‐Frequency Electrocochleography Results in Fewer Drop Alarms During Cochlear Implant Insertion
Espahbodi, Mana , Syed, Ali, Tu, Alex, Seidman, Michael D. , Danner, Christopher J., Allen, Kyle P., Bartels, Loren J., Ahsan, Syed F. , Voelker, Courtney C. J. , Deep, Nicholas L. , Chiffer, Rebecca C., Elrakhawy, Mohamed, Miller, Matthew W., Lin, Harrison W., Djalilian, Hamid R. , Angeli, Simon I., Kim, H J, Widick, Mark H., Stidham, Katrina R. , Patel, Neil S. , Koka, Kanthaiah , Hunter, Jacob B , Djalilian, Hamid R , Stidham, Katrina R , Gurgel, Richard Klaus , Doerfer, Karl W , Harris, Michael S , Danner, Christopher, Bartels, Loren Jay, Hunter, Jacob B. , Michaelides, Elias M. , Miller, Matthew W, Vivas, Esther , Angeli, Simón I., Hoa, Michael , Harris, Michael S.
The Laryngoscope | May 5, 2026 | Volume: No volume available | Issue: No issue available | Pages: No page available
ABSTRACT Objective To evaluate intracochlear electrocochleography (ECochG) amplitude parameters during cochlear implantation (CI) using a novel multi‐frequency ECochG algorithm. Methods A multi‐institutional, prospective cohort study was performed at 18 high‐volume CI centers. The inclusion criteria were adults with sensorineural hearing loss and audiometric thresholds of ≤ 90 dB hearing level at 500 Hz undergoing CI with Advanced Bionics (Valencia, CA) Ultra 3D devices between 2024 and 2025. ECochG recordings were performed with simultaneous multi‐frequency stimulation of four frequencies between 125 and 4000 Hz during cochlear implant insertion. Concurrent multi‐frequency recording allowed extraction of amplitude and phase of each frequency individually. Post hoc analysis was performed to determine the difference in the number of drop alarms between single‐ and multi‐frequency ECochG. An ECochG amplitude drop of 6 dB was defined as a drop alarm. Insertion track patterns were compared between single‐ and multi‐frequency ECochG. Results One hundred ninety‐five ears were included. Mean number of drop alarms for the single‐frequency algorithm was 1.72 (95% CI: 1.52, 1.92; median 1) compared to 0.42 (95% CI: 0.31, 0.53; median 0) for multi‐frequency; p < 0.001. The number of Type C patterns (rise in amplitude during insertion followed by a drop) decreased with the multi‐frequency ECochG algorithm compared to the single‐frequency ECochG algorithm. The number of Type D patterns (no‐response) decreased, indicating that multi‐frequency ECochG generated more responses across the cochlea than single‐frequency ECochG. Conclusions A novel multi‐frequency ECochG algorithm during CI is associated with fewer drop alarms and altered insertion track patterns, which may provide a more accurate assessment of the cochlear microenvironment. Level of Evidence 3.
Progenitor cell therapy for acquired pediatric nervous system injury: Traumatic brain injury and acquired sensorineural hearing loss
Baumgartner, James E. , Baumgartner, Linda S., Baumgartner, M. , Moore, Ernest J., Seidman, Michael D. , Messina, Steven A. , Shook, David R.
Stem Cells Translational Medicine | October 9, 2020 | Volume: 10 | Issue: 2 | Pages: 164-180
AbstractWhile cell therapies hold remarkable promise for replacing injured cells and repairing damaged tissues, cell replacement is not the only means by which these therapies can achieve therapeutic effect. For example, recent publications show that treatment with varieties of adult, multipotent stem cells can improve outcomes in patients with neurological conditions such as traumatic brain injury and hearing loss without directly replacing damaged or lost cells. As the immune system plays a central role in injury response and tissue repair, we here suggest that multipotent stem cell therapies achieve therapeutic effect by altering the immune response to injury, thereby limiting damage due to inflammation and possibly promoting repair. These findings argue for a broader understanding of the mechanisms by which cell therapies can benefit patients.