Citations 2
Primary mesenteric sarcomas: Collaborative experience from the Trans‐Atlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG)
Tattersall, Hannah L. , Hodson, James , Cardona, Kenneth , Lee, Rachel , Gladdy, Rebecca A. , Hage, Jos A. van der , Schrage, Yvonne , Tseng, William W. , Novak, Marko , Grignani, Giovanni , Tolomeo, Francesco , Ryon, Emily L. , Arnau, Ana Belén Martín , Sayyed, Raza , Tirotta, Fabio , Evenden, Caroline, Glasbey, James , Ford, Samuel , Lee, Rachel M , Tseng, William W , Bagaria, Sanjay P , Tirotta, Fabio , Fiore, Marco , Grignani, Giovanni , Nessim, Carolyn , Houdt, Winan J. van , Goel, Neha , Gyorki, David E. , Bagaria, Sanjay P. , Gonzalez, Jose A., Desai, Anant , Almond, Max , Fiore, Marco , Gronchi, Alessandro
Journal of Surgical Oncology | December 24, 2020 | Volume: 123 | Issue: 4 | Pages: 1057-1066
AbstractBackgroundPrimary mesenteric soft tissue sarcomas (STS) are rare and limited evidence is available to inform management. Surgical resection is challenging due to the proximity of vital structures and a need to preserve enteric function.ObjectivesTo determine the overall survival (OS) and recurrence‐free survival (RFS) for patients undergoing primary resection for mesenteric STS.MethodsThe Trans‐Atlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG) is an intercontinental collaborative comprising specialist sarcoma centers. Data were collected retrospectively for all patients with mesenteric STS undergoing primary resection between 2000 and 2019.ResultsFifty‐six cases from 15 institutions were included. The spectrum of pathology was similar to the retroperitoneum, although of a higher grade. R0/R1 resection was achieved in 87%. Median OS was 56 months. OS was significantly shorter in higher‐grade tumors (p = .018) and extensive resection (p < .001). No significant association between OS and resection margin or tumor size was detected. Rates of local recurrence (LR) and distant metastases (DM) at 5 years were 60% and 41%, respectively. Liver metastases were common (60%), reflecting portal drainage of the mesentery.ConclusionPrimary mesenteric sarcoma is rare, with a modest survival rate. LR and DM are frequent events. Liver metastases are common, highlighting the need for surveillance imaging.
Patterns of recurrence and survival probability after second recurrence of retroperitoneal sarcoma: A study from TARPSWG
Houdt, Winan J. van , Fiore, Marco , Barretta, Francesco , Blay, Jean‐Yves , Lahat, Guy, Strauß, D. , Ahuja, Nita , Grignani, Giovanni , Quagliuolo, Vittorio , Stoeckle, Eberhard , Schrage, Yvonne , Pennacchioli, Elisabetta , Swallow, Carol J. , Canter, Robert J. , Mullen, John T. , Fairweather, Mark , Miceli, Rosalba , Raut, Chandrajit P. , Gladdy, Rebecca A. , van Houdt, Winan J , Blay, Jean-Yves , Grignani, Giovanni , Bagaria, Sanjay P , Callegaro, Dario , Fiore, Marco , Rutkowski, Piotr , González, Ricardo , Paoli, Antonino De , Cardona, Kenneth , Pillarisetty, Venu Gopal , Nessim, Carolyn , Bagaria, Sanjay P. , Callegaro, Dario , Gronchi, Alessandro
Cancer | August 15, 2020 | Volume: 126 | Issue: 22 | Pages: 4917-4925
Background In this series from the Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG), the authors examined longitudinal outcomes of patients with a second recurrence of retroperitoneal sarcoma (RPS) after complete resection of a first local recurrence (LR). Methods Data from patients undergoing resection of a first LR from January 2002 to December 2011were collected from 22 sarcoma centers. The primary outcome was overall survival (OS) after second recurrence. Results Second recurrences occurred in 400 of 567 patients (70.5%) after an R0/R1 resection of a first locally recurrent RPS. Patterns of disease recurrence were LR in 323 patients (80.75%), distant metastases (DM) in 55 patients (13.75%), and both LR and DM in 22 patients (5.5%). The main subtype among the LR group was liposarcoma (77%), whereas DM mainly were leiomyosarcomas (43.6%). In patients with a second LR only, a total of 200 patients underwent re‐resection (61.9%). The 5‐year OS rate varied significantly based on the pattern of failure ( P < .001): 45.6% for the LR group, 25.5% for the DM group, and 0% for the group with LR and DM. The only factors found to be associated with improved OS on multivariable analysis were both time between second surgery and the development of the second recurrence (32 months vs 8 months: hazard ratio, 0.44 [ P < .001]) and surgery for second recurrence (yes vs no: hazard ratio, 3.25 [ P < .001]). The 5‐year OS rate for patients undergoing surgery for a second LR was 59% versus 18% in the patients not deemed suitable for surgical resection. Conclusions Survival rates after second recurrence of RPS varied based on patterns of disease recurrence and treatment. Durable disease‐free survivors were identified after surgery for second LR in patients selected for this intervention.