Edmonds, Victoria S.

Abstract Purpose The temporarily implanted nitinol device (TIND) is a minimally invasive surgical technique (MIST) for benign prostatic hyperplasia (BPH) that promises fewer unwanted side effects compared with traditional bladder outlet procedures for small glands with high-riding bladder necks, including transurethral incision of the prostate (TUIP). This study sought to compare the effect of TIND vs. TUIP on ejaculatory function in sexually active males using the Male Sexual Health Questionnaire Ejaculatory Function Short Form (MSHQ-EjD-SF). Methods A retrospective review of a prospectively maintained database of all patients who underwent TIND at our institution between 1/1/2022 and 10/1/2024. Patients were excluded if they reported no postoperative ejaculations. Patients who underwent TUIP during the same period were compared. Age, prostate volume, PSA, and urinary parameters were collected. MSHQ-EjD-SF scores were collected for all patients. Continuous variables were compared using Wilcoxon Rank sum test and categorical variables using Fisher’s exact test. Results A total of 27 patients underwent TIND, of which 17 reported postoperative ejaculations and were compared with 17 patients who underwent TUIP during the same period with similar baseline age, prostate volume, and urinary parameters. Median MSHQ-EjD-SF score was higher after TIND compared with TUIP (15.0 (14.0, 15.0) vs. 13.0 (11.0, 13.0), p < 0.01), while bother score was lower (0.0 (0.0, 0.0) vs. 1.0 (0.0, 2.0), p = 0.02). Conclusions Patients experienced negligible effect on ejaculatory function after TIND compared with TUIP. This may be an effective bladder outlet procedure for patients who prioritize their postoperative ejaculatory function.

Purpose: To compare stone clearance, stone-free status, and complications between patients undergoing ureteroscopy for renal stones using either Flexible and Navigable Ureteral Access Sheath (FANS) or the CVAC 2.0 system. Materials and Methods: A prospective study was completed on patients undergoing flexible ureteroscopy for renal stones at a single institution from March 2024 to December 2024. Subject demographics, intra-op data, volumetric and single-dimension stone clearance on non-contrast CT, and complications were compared. Stone-free rates (SFRs) using standardized cutoffs were compared. Pearson correlation analysis was performed to assess the relationship between preoperative stone volume and postoperative stone burden. Subanalysis was performed for patients with preoperative stone burden >1.5 cm. Results: A total of 123 cases (CVAC 2.0-36, FANS-87) were included, with 64 eligible for volumetric analysis. Preoperative stone volume was larger in the CVAC group vs FANS (1075 mm 3 vs 397 mm 3 ; p < 0.001). Absolute stone clearance was greater in the CVAC group (1016 mm 3 vs 392 mm 3 ; p < 0.001), whereas residual stone volume (4.1 mm 3 vs 15.0 mm 3 ; p = 0.55) and SFRs (90% vs 81%; p = 0.48) were similar. In individuals with >1.5 cm preoperative stone burden, relative stone clearance was greater with CVAC 2.0 (98.9% vs 95.1%; p = 0.026). Pearson correlation analysis revealed positive linear relationship between preoperative stone volume and residual stone volume for FANS, but not for CVAC 2.0. Conclusions: In this comparative study of FANS and CVAC 2.0, over 95% stone clearance was observed in both groups despite large initial stone burdens. In contrast to FANS, residual stone volumes with CVAC 2.0 did not increase significantly with increasing preoperative stone volumes.

Objective: There is little existing literature describing the evaluation and treatment of patients referred to surgical subspecialities for recurrent urinary tract infections (rUTIs). We hypothesised female patients referred to urology and urogynaecology for rUTI undergo multiple diagnostic tests and few would undergo surgery. Materials and Methods: This is a retrospective review of female patients referred to urology or urogynaecology at a single institution between 2016 and 2019. Data on demographics, provider speciality, diagnostic tests performed, and surgeries were abstracted. Descriptive statistics were used and a logistic regression was performed to determine the adjusted odds ratio of undergoing a surgery. Results: A total of 990 patients were included with a mean age of 62 and on average underwent 3.7 different testing modalities, including genitourinary (GU) examination (62.3%), urodynamic testing (72.7%), cystoscopy (66.0%), and imaging (70.7%). Urologists more commonly pursued urodynamic testing, cystoscopy, and imaging than urogynaecologists. Ultimately, 21.4% of all patients underwent a surgical procedure. Patients who were seen by urogynaecology, underwent GU examination, urodynamic testing, or cystoscopy had higher likelihoods of eventually undergoing surgery (procedure under anaesthesia). Conclusion: Female rUTI patients referred to urology or urogynaecology undergo considerable evaluation and testing. The majority of patients are ultimately managed medically rather than surgically, indicating continued need for resource stewardship. Level of evidence: Not applicable.

Objectives To compare postoperative complication rates of patients with metabolic syndrome (MetS) with patients without MetS after holmium laser enucleation of the prostate (HoLEP) for management of benign prostatic hyperplasia (BPH). Patients and Methods We retrospectively reviewed patients aged >40 years who underwent HoLEP at our institution from 2007 to 2022. Criteria for MetS were diagnoses of at least three of the following: diabetes mellitus, hypertension, hyperlipidaemia, or obesity (body mass index ≥30 kg/m 2 ). Uni‐ and multivariable logistic regression were used to compare the likelihood of immediate, 30‐day, and 90‐day complications between groups. Results A total of 1500 patients were included with a median (interquartile range) age of 70 (65–76) years. Patients with MetS were more likely to develop complications at both 30 and 90 days, including urinary incontinence, irritative voiding symptoms, and bleeding ( P < 0.001). After adjusting for potential confounders, patients with MetS had a greater than three times odds of both 30‐ and 90‐day complications compared to patients without MetS (30‐day adjusted odds ratio [aOR] 3.32, 95% confidence interval [CI] 2.21–5.01, P < 0.001; and 90‐day aOR 3.64, 95% CI 2.49–5.31, P < 0.001). Conclusion Metabolic syndrome was associated with a three‐fold likelihood of 30‐ and 90‐day complications after HoLEP. This could be an important factor to consider in preoperative counselling and patient selection.

ABSTRACT Background Large language model (LLM) chatbots, a form of artificial intelligence (AI) that excels at prompt‐based interactions and mimics human conversation, have emerged as a tool for providing patients with information about urologic conditions. We aimed to examine the quality of information related to benign prostatic hyperplasia surgery from four chatbots and how they would respond to sample patient messages. Methods We identified the top three queries in Google Trends related to “treatment for enlarged prostate.” These were entered into ChatGPT (OpenAI), Bard (Google), Bing AI (Microsoft), and Doximity GPT (Doximity), both unprompted and prompted for specific criteria (optimized). The chatbot‐provided answers to each query were evaluated for overall quality by three urologists using the DISCERN instrument. Readability was measured with the built‐in Flesch–Kincaid reading level tool in Microsoft Word. To assess the ability of chatbots to answer patient questions, we prompted the chatbots with a clinical scenario related to holmium laser enucleation of the prostate, followed by 10 questions that the National Institutes of Health recommends patients ask before surgery. Accuracy and completeness of responses were graded with Likert scales. Results Without prompting, the quality of information was moderate across all chatbots but improved significantly with prompting (mean [SD], 3.3 [1.2] vs. 4.4 [0.7] out of 5; p < 0.001). When answering simulated patient messages, the chatbots were accurate (mean [SD], 5.6 [0.4] out of 6) and complete (mean [SD], 2.8 [0.3] out of 3). Additionally, 98% (39/40) had a median score of 5 or higher for accuracy, which corresponds to “nearly all correct.” The readability was poor, with a mean (SD) Flesch–Kincaid reading level grade of 12.1 (1.3) (unprompted). Conclusions LLM chatbots hold promise for patient education, but their effectiveness is limited by the need for careful prompting from the user and by responding at a reading level higher than that of most Americans (grade 8). Educating patients and physicians on optimal LLM interaction is crucial to unlock the full potential of chatbots.

Clinical History: A 60-year-old female was found to have a 2 cm Ureteropelvic junction (UPJ) stone in an ectopic right pelvic kidney while undergoing evaluation for gross hematuria. She had no prior stone history and normal renal function. Physical Exam: Physical exam was unremarkable. Computed tomography (CT) Urogram revealed a medial, pelvic kidney with overlying bowel and posterior, tortuous ureter. Renal vein ran longitudinally along the anterior surface of the kidney. Diagnosis: A 2 cm UPJ stone in an ectopic right pelvic kidney. Intervention: Given tortuosity of the ureter and overlying bowel precluded an endoscopic approach, we proceeded with robotic-assisted pyelolithotomy. 1 An open-ended ureteral catheter was advanced to allow for distension of the renal pelvis. After placing robotic trocars, peritoneum and Gerota’s fascia were dissected off the anterior surface of the kidney. Robotic Potts were used to enter the renal pelvis. No stone was visible, thus antegrade ureteroscopy was performed through a robotic port, demonstrating an impacted 2 cm lower pole stone. We performed antegrade ureteroscopy, laser lithotripsy, and basket-extraction. A robotic suction arm was employed to remove remaining dust. A double-J ureteral stent was placed antegrade, and pyelotomy was closed in a running fashion. Follow-Up/Outcomes: The patient had an uneventful postoperative course and CT at 6 weeks demonstrated no residual stone. Laparoscopic or robotic-assisted pyelolithotomy demonstrates higher stone free rates in pelvic kidneys compared with endoscopic treatment (97.2% vs 65.9%–84.9%). 2 However, surgical approach should be decided based on patients’ anatomy, stone density and location, and surgeon experience. Author Disclosure Statement: The authors have no conflicts of interest to disclose. Patient Consent Statement: Authors have received and archived patient consent for video recording/publication in advance of video recording of procedure. Music: Music was obtained from www.pixabay.com and is no copyright music, free for use. Exact Runtime of video: 5 min 00 sec.

Abstract Introduction Despite direct access to clinicians through the electronic health record, patients are increasingly turning to the internet for information related to their health, especially with sensitive urologic conditions such as Peyronie’s disease (PD). Large language model (LLM) chatbots are a form of artificial intelligence that rely on user prompts to mimic conversation, and they have shown remarkable capabilities. The conversational nature of these chatbots has the potential to answer patient questions related to PD; however, the accuracy, comprehensiveness, and readability of these LLMs related to PD remain unknown. Aims To assess the quality and readability of information generated from 4 LLMs with searches related to PD; to see if users could improve responses; and to assess the accuracy, completeness, and readability of responses to artificial preoperative patient questions sent through the electronic health record prior to undergoing PD surgery. Methods The National Institutes of Health’s frequently asked questions related to PD were entered into 4 LLMs, unprompted and prompted. The responses were evaluated for overall quality by the previously validated DISCERN questionnaire. Accuracy and completeness of LLM responses to 11 presurgical patient messages were evaluated with previously accepted Likert scales. All evaluations were performed by 3 independent reviewers in October 2023, and all reviews were repeated in April 2024. Descriptive statistics and analysis were performed. Results Without prompting, the quality of information was moderate across all LLMs but improved to high quality with prompting. LLMs were accurate and complete, with an average score of 5.5 of 6.0 (SD, 0.8) and 2.8 of 3.0 (SD, 0.4), respectively. The average Flesch-Kincaid reading level was grade 12.9 (SD, 2.1). Chatbots were unable to communicate at a grade 8 reading level when prompted, and their citations were appropriate only 42.5% of the time. Conclusion LLMs may become a valuable tool for patient education for PD, but they currently rely on clinical context and appropriate prompting by humans to be useful. Unfortunately, their prerequisite reading level remains higher than that of the average patient, and their citations cannot be trusted. However, given their increasing uptake and accessibility, patients and physicians should be educated on how to interact with these LLMs to elicit the most appropriate responses. In the future, LLMs may reduce burnout by helping physicians respond to patient messages.