Citations 92
P1‐139: THE CONTRIBUTION OF SEX‐SPECIFIC ASSOCIATIONS IN GENETIC STUDIES OF ALZHEIMER'S DISEASE PATHOLOGY
Deming, Yuetiva, Beecham, Gary W. , Kunkle, Brian W. , Fagan, Anne M. , Jager, Philip L. De , Albert, Marilyn S. , Riemenschneider, Matthias, Petersen, Ronald C. , Thambisetty, Madhav , Resnick, Susan M. , Keene, Dirk, Montine, Thomas J. , Blennow, Kaj , Minthon, Lennart, Shaw, Leslie M. , Trojanowski, John Q. , Larson, Eric B. , Johnson, Sterling C., Schellenberg, Gerard D. , Haines, Jonathan L. , Peskind, Elaine R. , Li, Ge , Jefferson, Angela L. , Dumitrescu, Logan , Lu, Qiongshi , Del‐Aguila, Jorge L. , Fernández, María Victoria , Budde, John , Moghekar, Abhay , Riemenschneider, Matthias, Barnes, Lisa L. , Gifford, Katherine A. , Bush, William S. , Chibnik, Lori Beth , Mukherjee, Shubhabrata , Kukull, Walter A. , Crane, Paul K. , Zetterberg, Henrik , Deerlin, Vivianna M. Van , Lee, Virginia M.‐Y. , Johnson, Sterling C. , Cox, Nancy J. , Goate, Alison , Cruchaga, Carlos , Bennett, David , Schneider, Julie A. , Hohman, Timothy J.
Alzheimer's & Dementia | October 22, 2018 | Volume: 14 | Issue: 7S_Part_6 | Pages: No page available
New thinking about thinking, part two. Theoretical articles for Alzheimer's & Dementia
Khachaturian, Ara S. , Hayden, Kathleen M. , Mielke, Michelle M. , Lutz, Michael W. , Gold, Michael , Kukull, Walter A. , Mohs, Richard C. , Gauthier, Serge , Khachaturian, Zaven S., Mielke, Michelle M , Tang, Yi , Molinuevo, José Luís , Zetterberg, Henrik
Alzheimer's & Dementia | May 26, 2018 | Volume: 14 | Issue: 6 | Pages: 703-706
Future prospects and challenges for Alzheimer's disease drug development in the era of the NIA‐AA Research Framework
Khachaturian, Ara S. , Hayden, Kathleen M. , Mielke, Michelle M. , Lutz, Michael W. , Gustafson, Deborah , Kukull, Walter A. , Mohs, Richard C. , Khachaturian, Zaven S., Mielke, Michelle M , Tang, Yi
Alzheimer's & Dementia | April 10, 2018 | Volume: 14 | Issue: 4 | Pages: 532-534
[P2–317]: PHENOCONVERSION FROM ASYMPTOMATIC TO MINIMALLY SYMPTOMATIC FTLD: PRELIMINARY DATA IN THE LEFFTDS COHORT
Rosen, Howard J. , Boxer, Adam L. , Coppola, Giovanni , Dheel, Christina, Fields, Julie A. , Gavrilova, Ralitza H. , Ghoshal, Nupur , Graff‐Radford, Neill R. , Heuer, Hilary W. , Huey, Edward D. , Kornak, John , Kraft, Ruth, Kramer, Joel H. , Mackenzie, Ian R. , Miller, Matt R., Phelps, Creighton H., Rademakers, Rosa , Rankin, Katherine , Sutherland, Marg, Syrjanen, Jeremy A. , Taylor, Joanne, Weıntraub, Sandra , Boeve, Bradley F. , Dickerson, Bradford Clark , Fong, Jamie , Goldman, Jill , Grossman, Murray , Hsiao, John , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Knopman, David S. , Kukull, Walter A. , Miller, Bruce L. , Wszołek, Zbigniew K.
Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_15 | Pages: No page available
[P2–303]: ADVANCING RESEARCH AND TREATMENT IN FRONTOTEMPORAL LOBAR DEGENERATION (ARTFL) NORTH AMERICAN RARE DISEASE CLINICAL RESEARCH CONSORTIUM: PROGRESS AND CHARACTERIZATION OF INITIAL PARTICIPANTS
Boxer, Adam L. , Rosen, Howard J. , Heuer, Hilary W. , Coppola, Giovanni , Bordelon, Yvette , Dheel, Christina, Faber, Kelley , Fields, Julie A. , Ghoshal, Nupur , Graff-Radford, N. R., Huey, Edward D. , Kaufer, Daniel , Karydas, Anna, Kramer, Joel H. , Lungu, Codrin , Mackenzie, Ian R. , Mendez, Mario F. , Miller, Matt R., Onyike, Chiadi U. , Pantelyat, Alex, Potter, Madeline, Rademakers, Rosa , Sutherland, Margaret , Weıntraub, Sandra , Boeve, Bradley F. , Grossman, Murray , Dickerson, Bradford Clark , Fong, Jamie , Foroud, Tatiana , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Kantarci, Kejal , Knopman, David S. , Kukull, Walter A. , Litvan, Irene , Miller, Bruce L. , Roberson, Erik D. , Tartaglia, Maria Carmela , Toga, Arthur W. , Wszołek, Zbigniew K.
Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_15 | Pages: No page available
[P1–254]: CHARACTERISTICS AND PROGRESS ON THE INITIAL 209 SUBJECTS IN THE LONGITUDINAL EVALUATION OF FAMILIAL FRONTOTEMPORAL DEMENTIA SUBJECTS (LEFFTDS) PROTOCOL
Dheel, Christina, Rosen, Howard J. , Boxer, Adam L. , Coppola, Giovanni , Faber, Kelley, Fields, Julie A. , Gavrilova, Ralitza H. , Ghoshal, Nupur , Graff-Radford, N. R., Heuer, Hilary W. , Huey, Edward D. , Karydas, Anna, Kornak, John , Kramer, Joel H. , Mackenzie, Ian R. , Miller, Matt R., Phelps, Creighton H., Rademakers, Rosa , Rankin, Katherine , Shaw, Leslie M. , Sutherland, Margaret , Syrjanen, Jeremy A. , Trojanowski, John Q. , Vetor, Ashley, Weıntraub, Sandra , Boeve, Bradley F. , Dickerson, Bradford Clark , Foroud, Tatiana , Goldman, Jill , Grossman, Murray , Hsiao, John , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Kantarci, Kejal , Knopman, David S. , Kukull, Walter A. , Miller, Bruce L. , Toga, Arthur W. , Wszołek, Zbigniew K.
Alzheimer's & Dementia | October 20, 2017 | Volume: 13 | Issue: 7S_Part_7 | Pages: No page available
Transethnic genome‐wide scan identifies novel Alzheimer's disease loci
Jun, Gyungah , Chung, Jaeyoon , Beecham, Gary W. , Bennett, David A. , Buxbaum, Joseph D. , Byrd, Goldie S. , Carrasquillo, Minerva M., Crane, Paul K. , Cruchaga, Carlos , Jager, Philip L. De , Ertekin‐Taner, Nilüfer , Evans, Denis A., Fallin, M. Danielle, Friedland, Robert P. , Goate, Alison , Graff‐Radford, Neill R. , Hendrie, Hugh C. , Hall, Kathleen, Hamilton‐Nelson, Kara L., Kukull, Walter A. , Kunkle, Brian W. , Kuwano, Ryozo, Larson, Eric B., Martin, Eden R. , Montine, Thomas J. , Reiman, Eric M. , Reitz, Christiane, Sherva, Richard , George‐Hyslop, Peter St , Thornton, Timothy, Younkin, Steven G., Wang, Li‐San , Wendlund, Jens R., Winslow, Ashley R. , Adams, Perrie M. , Albert, Marilyn S. , Albin, Roger L. , Apostolova, Liana G. , Arnold, Steven E. , Asthana, Sanjay , Atwood, Craig , Barmada, Michjael M, Beach, Thomas G. , Bigio, Eileen H. , Bird, Thomas D., Blacker, Deborah , Bowen, James D. , Boxer, Adam, Cairns, Nigel J. , Cao, Chuanhai , Carlson, Chris , Carlsson, Cynthia M., Carney, Regina M., Carroll, Steven L. , Chui, Helena C., Clark, David G., Corneveaux, Jason J., Cribbs, David H. , DeKosky, Steven T. , Demirci, F. Yesim , Dick, Malcolm, Doody, Rachelle S., Duara, Ranjan , Faber, Kelley , Fairchild, Thomas, Fallon, Kenneth B., Farlow, Martin R. , Frosch, Matthew P. , Gearing, Marla , Geschwind, Daniel H. , Gilbert, John R., Glass, Jonathan D. , Growdon, John H., Håkonarson, Håkon , Hamilton, Ronald L. , Hardy, John , Harrell, Lindy E., Huentelman, Matthew J. , Hulette, Christine M., Jarvik, Gail P. , Jicha, Gregory A. , Jin, Lee‐Way, Karydas, Anna, Koo, Edward H. , Kowall, Neil W. , Kramer, Joel H. , LaFerla, Frank M. , Leverenz, James B. , Ge, Li , Lieberman, Andrew P. , Lin, Chiao‐Feng , Lyketsos, Constantine G. , Mack, Wendy J. , Marson, Daniel , Martiniuk, Frank , Mash, Deborah C. , Masliah, Eliezer , McCormick, Wayne C., McKee, Ann C. , Mesulam, Marsel, Miller, Carol A., Miller, Joshua W., Morris, John C. , Murrell, Jill R. , Olichney, John , Parisi, Joseph E., Partch, Amanda, Paulson, Henry L. , Peskind, Elaine R. , Petersen, Ronald , Pierce, Aimee, Poon, Wayne W. , Raj, Ashok , Raskind, Murray A. , Reisch, Joan, Ringman, John M. , Rosen, Howard J., Rosenberg, Roger N., Royall, Donald R., Sager, Mark A., Sano, Mary , Saykin, Andrew J. , Schneider, Lon S. , Smith, Amanda , Sonnen, Joshua A. , Tanzi, Rudolph E. , Thornton‐Wells, Tricia A., Trojanowski, John Q. , Troncoso, Juan C. , Vinters, Harry V. , Vonsattel, Jean Paul, Weıntraub, Sandra , Wishnek, Sarah, Woltjer, Randall L. , Wright, Clinton B., Wu, Chuang‐Kuo, Yu, Chang‐En , Yu, Lei , Haines, Jonathan L. , Mayeux, Richard , Pericak‐Vance, Margaret A. , Schellenberg, Gerard, Lunetta, Kathryn L. , Farrer, Lindsay A. , Bennett, David A. , Mez, Jesse , Barber, Robert C. , Carrasquillo, Minerva M. , Cruchaga, Carlos , Foroud, Tatiana , Hamilton‐Nelson, Kara L. , Inzelberg, Rivka , Kamboh, M. Ilyas , Kauwe, John S. K. , Logue, Mark W. , Manly, Jennifer J. , Mukherjee, Shubhabrata , Naj, Adam Christian , Sherva, Richard , Vardarajan, Badri Narayan , Barnes, Lisa L. , Becker, James T. , Boeve, Bradley F. , Burke, James R. , Carlsson, Cynthia M. , Chui, Helena C. , Crocco, Elizabeth , DeCarli, Charles , Dickson, Dennis W. , Duara, Ranjan , Ferris, Steven H. , Galasko, Douglas , Ghetti, Bernardino , Green, Robert C. , Head, Elizabeth , Honig, Lawrence S. , Huebinger, Ryan , Hyman, Bradley T. , Kaye, Jeffrey , Kim, Ronald , Lah, James J. , Levey, Allan I. , Li, Ge, López, Oscar L. , McCurry, Susan M. , McDavid, Andrew , Mesulam, Marsel M. , Miller, Bruce L. , Myers, Amanda , O’Bryant, Sid E. , Pankratz, V. Shane , Perry, William , Potter, Huntington , Quinn, Joseph F. , Reisberg, Barry , Roberson, Erik D. , Rogaeva, Ekaterina A. , Schneider, Julie A. , Seeley, William W. , Spina, Salvatore , Stern, Robert A. , Tsuang, Debby W. , Deerlin, Vivianna M. Van , Eldik, Linda J. Van , Welsh-Bohmer, Kathleen Anne , Williamson, Jennifer , Zhang, Xiaoling , Hakonarson, Hakon , Saykin, Andrew J , Leverenz, James B , Jarvik, Gail P , Paulson, Henry L , Hardy, John , Morris, John C , Goate, Alison M , Jicha, Gregory A , Sonnen, Joshua
Alzheimer's & Dementia | February 6, 2017 | Volume: 13 | Issue: 7 | Pages: 727-738
Abstract Introduction Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood. Methods We conducted a transethnic genome‐wide association study (GWAS) for late‐onset AD in Stage 1 sample including whites of European Ancestry, African‐Americans, Japanese, and Israeli‐Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset. Results Genome‐wide significant (GWS) associations in single‐nucleotide polymorphism (SNP)–based tests ( P < 5 × 10 −8 ) were identified for SNPs in PFDN1/HBEGF , USP6NL/ECHDC3 , and BZRAP1‐AS1 and for the interaction of the (apolipoprotein E) APOE ε4 allele with NFIC SNP. We also obtained GWS evidence ( P < 2.7 × 10 −6 ) for gene‐based association in the total sample with a novel locus, TPBG ( P = 1.8 × 10 −6 ). Discussion Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci.
Duration and Pathologic Correlates of Lewy Body Disease
Graff‐Radford, Jonathan , Aakre, Jeremiah A. , Savica, Rodolfo , Kremers, Walter K. , Ferman, Tanis J. , Kantarci, Kejal , Kukull, Walter A. , Petersen, Ronald C. , Aakre, Jeremiah, Boeve, Bradley F. , Jones, David T. , Knopman, David S. , Dickson, Dennis W. , Kantarci, Kejal , Ferman, Tanis J , Kremers, Walter K
JAMA Neurology | January 23, 2017 | Volume: 74 | Issue: 3 | Pages: 310
Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans
Chung, Jaeyoon , Jun, Gyungah , Kriegel, Joshua, Bourlas, Alexandra P., Sherva, Richard , Barnes, Lisa L. , Bennett, David A. , Buxbaum, Joseph D. , Byrd, Goldie S. , Crane, Paul K. , Ertekin‐Taner, Nilüfer , Evans, Denis A., Fallin, M. Daniele , Goate, Alison , Graff‐Radford, Neill R. , Hall, Kathleen, Kukull, Walter A. , Larson, Eric B., Haines, Jonathan L. , Mayeux, Richard , Pericak‐Vance, Margaret A. , Schellenberg, Gerard D. , Lunetta, Kathryn L. , Farrer, Lindsay A. , Bennett, David A. , Mez, Jesse , Sherva, Richard , Logue, Mark W. , Foroud, Tatiana , Kamboh, M. Ilyas , Manly, Jennifer J. , Goate, Alison M , Barnes, Lisa L
Alzheimer's & Dementia | October 20, 2016 | Volume: 13 | Issue: 2 | Pages: 119-129
AbstractIntroductionAfrican Americans' (AAs) late‐onset Alzheimer's disease (LOAD) genetic risk profile is incompletely understood. Including clinical covariates in genetic analyses using informed conditioning might improve study power.MethodsWe conducted a genome‐wide association study (GWAS) in AAs employing informed conditioning in 1825 LOAD cases and 3784 cognitively normal controls. We derived a posterior liability conditioned on age, sex, diabetes status, current smoking status, educational attainment, and affection status, with parameters informed by external prevalence information. We assessed association between the posterior liability and a genome‐wide set of single‐nucleotide polymorphisms (SNPs), controlling for APOE and ABCA7, identified previously in a LOAD GWAS of AAs.ResultsTwo SNPs at novel loci, rs112404845 (P = 3.8 × 10−8), upstream of COBL, and rs16961023 (P = 4.6 × 10−8), downstream of SLC10A2, obtained genome‐wide significant evidence of association with the posterior liability.DiscussionAn informed conditioning approach can detect LOAD genetic associations in AAs not identified by traditional GWAS.
P1‐337: African American Brain Autopsies from The National Alzheimer’s Coordinating Center
Graff‐Radford, Neill R. , Besser, Lilah M. , Crook, Julia E. , Kukull, Walter A. , Dickson, Dennis W.
Alzheimer's & Dementia | October 17, 2016 | Volume: 12 | Issue: 7S_Part_11 | Pages: No page available