Citations 2
White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities
Alber, Jessica , Alladi, Suvarna , Barton, David A., Bell, Joanne M., Berman, Sara E., Biessels, Geert Jan , Bos, Isabelle , Bowman, Gene L. , Brai, Emanuele , Callahan, Brandy L. , Corriveau, Roderick A. , Fossati, Silvia , Gottesman, Rebecca F. , Gustafson, Deborah , Hachinski, Vladimir , Hayden, Kathleen M. , Helman, Alex M., Hughes, Timothy M. , Isaacs, Jeremy D. , Jefferson, Angela L. , Kern, Silke , Kwon, Jay C., Lee, Athene , Lockhart, Samuel N. , Murray, Anne M. , Osborn, Katie E. , Price, Brittani R. , Rhodius‐Meester, Hanneke , Rondeau, Jacqueline A., Rosen, Allyson , Scholtzova, Henrieta , Shaaban, C. Elizabeth , Silva, Nárlon Cássio Boa Sorte , Snyder, Heather M. , Swardfager, Walter , Troen, Aron M. , Vemuri, Prashanthi , Wallin, Anders , Wellington, Cheryl L. , Xie, Sharon X. , Hainsworth, Atticus H. , Vemuri, Prashanthi , Gottesman, Rebecca F , Hainsworth, Atticus H , Bae, Hee‐Joon , Beckett, Laurel , Biessels, Geert Jan , Black, Sandra E. , Brickman, Adam M. , Johnson, Sterling C. , Kapasi, Alifiya , Kukolja, Juraj , Power, Melinda C. , Rosene, Douglas L , Schneider, Julie A. , Veluw, Susanne J. van , Wilcock, Donna M.
Alzheimer's & Dementia: Translational Research & Clinical Interventions | April 8, 2019 | Volume: 5 | Issue: 1 | Pages: 107-117
Abstract White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]). WMHs are also seen in cognitively healthy people. In this collaboration of academic, clinical, and pharmaceutical industry perspectives, we identify outstanding questions about WMHs and their relation to cognition, dementia, and AD. What molecular and cellular changes underlie WMHs? What are the neuropathological correlates of WMHs? To what extent are demyelination and inflammation present? Is it helpful to subdivide into periventricular and subcortical WMHs? What do WMHs signify in people diagnosed with AD? What are the risk factors for developing WMHs? What preventive and therapeutic strategies target WMHs? Answering these questions will improve prevention and treatment of WMHs and dementia.
Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need
Quiroz, Yakeel T. , Albensi, Benedict C. , Astell, Arlene , Babiloni, Claudio , Bahar‐Fuchs, Alex , Bowman, Gene L. , Chételat, Gaël , Ciro, Carrie , Cohen, Ann D. , Dilworth‐Anderson, Peggye, Dreux, Simone, Edland, Steven D. , Esbensen, Anna J. , Ewers, Michael , Fargo, Keith N. , Fortea, Juan , González, Héctor M. , Gustafson, Deborah , Head, Elizabeth , Hendrix, James A. , Hofer, Scott M. , Johnson, Leigh , Jutten, Roos J. , Kilborn, Kerry, Martins, Ralph N. , Morris, Martha Clare , Murray, Melissa E. , Parra, Mario A. , Roe, Catherine M. , Santos, Octavio A. , Scarmeas, Nikolaos , Schneider, Lon S. , Schupf, Nicole , Sikkes, Sietske A.M. , Snyder, Heather M. , Sohrabi, Hamid R. , Strydom, André , Muñiz‐Terrera, Graciela , Teunissen, Charlotte E. , Lent, Debora Melo van , Weinborn, Michael , Wesselman, Linda M.P. , Arenaza-Urquijo, Eider, Teunissen, Charlotte E , Fortea, Juan , Murray, Melissa E , Babulal, Ganesh M. , Arenaza‐Urquijo, Eider M. , Bell, J. Simon , Brickman, Adam M. , Dodge, Hiroko Hayama , Evered, Lisbeth Anne , Gonzalez, Hector M , Lanctôt, Krista L. , Manly, Jennifer J. , Mielke, Michelle M. , Oh, Esther S , Rissman, Robert A. , Stern, Yaakov , Tang, Yi , Wilcock, Donna M. , Zetterberg, Henrik , O’Bryant, Sid E. , Head, Elizabeth , Cohen, Annie
Alzheimer's & Dementia | December 13, 2018 | Volume: 15 | Issue: 2 | Pages: 292-312
Abstract Alzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging population and society as a whole. With the numbers of people with ADRDs predicted to rise dramatically across the world, the scientific community can no longer neglect the need for research focusing on ADRDs among underrepresented ethnoracial diverse groups. The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART; alz.org/ISTAART ) comprises a number of professional interest areas (PIAs), each focusing on a major scientific area associated with ADRDs. We leverage the expertise of the existing international cadre of ISTAART scientists and experts to synthesize a cross‐PIA white paper that provides both a concise “state‐of‐the‐science” report of ethnoracial factors across PIA foci and updated recommendations to address immediate needs to advance ADRD science across ethnoracial populations.