Citations 2
Accelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: The Role of Epidemiology
Kritchevsky, Stephen B. , Guralnik, Jack M. , Cummings, Steven R. , Salive, Marcel E. , Kuchel, George A. , Schrack, Jennifer A. , Morris, Martha Clare , Weir, David R. , Ben‐Shlomo, Yoav , Kirkland, James L. , Ferrucci, Luigi , Kirkland, James, Ferrucci, Luigi , Kritchevsky, Stephen B , Kuchel, George A , Newman, Anne B. , Baccarelli, Andrea , Murabito, Joanne M. , Espeland, Mark Andrew , Melzer, David R.
The Journals of Gerontology: Series A | November 13, 2019 | Volume: 75 | Issue: 1 | Pages: 77-86
Abstract Background Extensive work in basic and clinical science suggests that biological mechanisms of aging are causally related to the development of disease and disability in late life. Modulation of the biological mechanisms of aging can extend both life span and health span in animal models, but translation to humans has been slow. Methods Summary of workshop proceedings from the 2018–2019 Epidemiology of Aging Workshop hosted by the Intramural Research Program at the National Institute on Aging. Results Epidemiologic studies play a vital role to progress in this field, particularly in evaluating new risk factors and measures of biologic aging that may influence health span, as well as developing relevant outcome measures that are robust and relevant for older individuals. Conclusions Appropriately designed epidemiological studies are needed to identify targets for intervention and to inform study design and sample size estimates for future clinical trials designed to promote health span.
Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need
Quiroz, Yakeel T. , Albensi, Benedict C. , Astell, Arlene , Babiloni, Claudio , Bahar‐Fuchs, Alex , Bowman, Gene L. , Chételat, Gaël , Ciro, Carrie , Cohen, Ann D. , Dilworth‐Anderson, Peggye, Dreux, Simone, Edland, Steven D. , Esbensen, Anna J. , Ewers, Michael , Fargo, Keith N. , Fortea, Juan , González, Héctor M. , Gustafson, Deborah , Head, Elizabeth , Hendrix, James A. , Hofer, Scott M. , Johnson, Leigh , Jutten, Roos J. , Kilborn, Kerry, Martins, Ralph N. , Morris, Martha Clare , Murray, Melissa E. , Parra, Mario A. , Roe, Catherine M. , Santos, Octavio A. , Scarmeas, Nikolaos , Schneider, Lon S. , Schupf, Nicole , Sikkes, Sietske A.M. , Snyder, Heather M. , Sohrabi, Hamid R. , Strydom, André , Muñiz‐Terrera, Graciela , Teunissen, Charlotte E. , Lent, Debora Melo van , Weinborn, Michael , Wesselman, Linda M.P. , Arenaza-Urquijo, Eider, Teunissen, Charlotte E , Fortea, Juan , Murray, Melissa E , Babulal, Ganesh M. , Arenaza‐Urquijo, Eider M. , Bell, J. Simon , Brickman, Adam M. , Dodge, Hiroko Hayama , Evered, Lisbeth Anne , Gonzalez, Hector M , Lanctôt, Krista L. , Manly, Jennifer J. , Mielke, Michelle M. , Oh, Esther S , Rissman, Robert A. , Stern, Yaakov , Tang, Yi , Wilcock, Donna M. , Zetterberg, Henrik , O’Bryant, Sid E. , Head, Elizabeth , Cohen, Annie
Alzheimer's & Dementia | December 13, 2018 | Volume: 15 | Issue: 2 | Pages: 292-312
Abstract Alzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging population and society as a whole. With the numbers of people with ADRDs predicted to rise dramatically across the world, the scientific community can no longer neglect the need for research focusing on ADRDs among underrepresented ethnoracial diverse groups. The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART; alz.org/ISTAART ) comprises a number of professional interest areas (PIAs), each focusing on a major scientific area associated with ADRDs. We leverage the expertise of the existing international cadre of ISTAART scientists and experts to synthesize a cross‐PIA white paper that provides both a concise “state‐of‐the‐science” report of ethnoracial factors across PIA foci and updated recommendations to address immediate needs to advance ADRD science across ethnoracial populations.