Citations

Abstract Radiotherapy is an established treatment for low-grade primary cutaneous B-cell lymphoma. Recommendations on its use differ internationally, which prompted our group to conduct this analysis. Twenty-two institutions participated in this international study. Patient eligibility required a diagnosis of limited (T1/T2) primary cutaneous marginal zone or follicle center lymphoma treated with radiotherapy between 1995 and 2023. Data were collected retrospectively until February 2024 within the framework of the International Lymphoma Radiation Oncology Group. Overall, 535 patients were analyzed. Predominant locations were the head (40%) and trunk (36%). Radiotherapy had a median dose of 24 Gy in fractions of 2 Gy. Complete responses were observed in 91% at a median time of 3.6 months following radiotherapy. There was no statistically significant difference between treatments ≤4 Gy and >4 Gy for complete or overall response rates (P = .077 and P = .056, respectively). However, there was an inferior duration of local control with ≤4 Gy (5-year local control 73% ± 12% vs 96% ± 2%; P< .001). Radiation dose was the main prognostic factor in the univariate and multivariable Cox analysis; however, higher doses did not translate into an overall survival benefit. Toxicities rarely exceeded grade 2 but were more frequent in the >4 Gy group. Radiotherapy remains an effective treatment option for indolent skin lymphoma with low toxicity. High response rates are observed with low doses of ≤4 Gy. In comparison to conventional doses, these treatments have a shorter duration of local control but a favorable toxicity profile.

Background TAR DNA-binding protein 43 (TDP-43) proteinopathy contributes to Alzheimer's disease progression, but diagnosis remains autopsy-dependent. Objective This study aimed to develop a predictive model using FDG-PET imaging to identify brain regions associated with TDP-43 pathology in vivo. Methods Penalized logistic regression analyzed data from 294 participants and a subset of 159 with Braak and Thal ≥4. Features included FDG standard uptake value ratios (SUVRs) from 123 brain regions and age. Participants were split into training (90%) and testing (10%) datasets, with significant predictors identified by non-zero coefficients at optimal lambda. Results The model achieved 68% accuracy (AUC = 0.70) in 294 participants, highlighting the middle temporal gyrus, parahippocampal gyrus, and hippocampus. In the subset (n = 159), accuracy was 65% (AUC = 0.71), with the medial amygdala and precentral gyrus as key predictors of TDP-43 pathology. Conclusions This study suggests a moderate predictive accuracy of FDG-PET to identify brain regions associated with Alzheimer's disease-related TDP-43 proteinopathy.

After implementing a process for flagging readmitted radiopharmaceutical therapy patients, it was discovered that major assumptions for these patients were not correct, specifically the magnitude of patients and the location of the readmissions. Data collected from May to December 2024 revealed 501 post-therapy patient encounters out of 1,139 administrations. Analysis showed varying return rates across different radiopharmaceuticals and departments, highlighting the need for updated radiation safety response. Results indicated that most encounters occurred in outpatient settings, with contamination above action levels found in 61% of responses. The study underscores the importance of continuous assessment and collaboration among stakeholders to adapt to new radiopharmaceutical therapies and ensure effective radiation safety practices.

The radiopharmaceutical therapy field is experiencing a surge of novel treatments and expanded uses for existing treatments, broadening the range of patients that can be treated. This expansion presents new challenges for managing patient release due to new patient populations with additional comorbidities, increasing the incidence of patients requiring care shortly after administration. This paper outlines the challenges and potential solutions for managing readmitted radiopharmaceutical therapy patients. It discusses the importance of having radiation protection policies and procedures in place for staff who may be unfamiliar with radiation. The paper also highlights the need for just-in-time training and radiation monitoring equipment for care staff, as well as the development of a notification system within the electronic health record to ensure staff can safely care for these patients. Preparing for these eventualities is essential for implementing a radiopharmaceutical therapy program that is ready for the expansion of existing and novel treatments.

Purpose To determine if preoperative femoral or tibial bone marrow edema (BME) is indicative of higher rates of re‐tear and conversion to total knee arthroplasty (TKA) after posterior medial meniscal root tear repair, and, secondarily, whether preoperative BME impacted patient‐reported outcome measures and rates of infection and arthrofibrosis. Methods Patients that underwent posterior medial meniscal root tear repair between 2013 and 2021 with a 2‐year minimum follow‐up were retrospectively analyzed. Primary outcome measures included re‐tears and TKA conversion. Secondary outcomes included International Knee Documentation Committee (IKDC) score and Lysholm score, infection, and arthrofibrosis. Cohort‐specific minimally clinically important difference and Patient Acceptable Symptomatic Scale rates were calculated. Two‐tailed t‐tests, Wilcoxon rank‐sum tests, and Fisher's exact tests were used where appropriate. Results The study population consisted of 97 knees (74 without BME [NBME], 23 with BME) with average follow‐up of 38.9 months (24‐68). Preoperatively, the NBME group had higher IKDC scores ( P = .008). Postoperatively, the NBME group had higher IKDC scores at 6 months, 1 year, and 2 years (84.5 [6.0] vs 68.5 [11.0]) ( P = .041, <.001, <.001). IKDC minimally clinically important difference rates were not significantly different between groups at all follow‐ups. Patient Acceptable Symptomatic Scale rates were higher for the NBME group at 1‐year and final follow‐up (100.0% vs 60.9%) ( P < .001 for both). Lysholm scores were higher for the NBME group at 1‐year and final follow‐up (84.0 [5.6] vs 74.6 [12.8]) ( P = .019 and .008, respectively). Re‐tear occurred in 17.4% of the BME group and 0% of the NBME group ( P = .003). TKA conversion rates were 21.7% in the BME group and 2.7% in the NBME group ( P = .008). There was no difference in arthrofibrosis or infection rates. Conclusions Preoperative BME in patients undergoing posterior medial meniscal root tear repair is associated with higher rates of recurrent meniscal root tearing and conversion to TKA in addition to lower subjective IKDC and Lysholm scores compared to patients without preoperative BME. Level of Evidence Level III, retrospective prognostic case control series.

BACKGROUND AND OBJECTIVES: Contemporary skull base surgeons must understand transcranial and endoscopic endonasal approaches to the petrous apex (PA). We provide an anatomic overview and comparison of main approaches to the PA through illustrative anatomic dissections. METHODS: On 10 sides of 5 specimens, transcranial approaches to the PA including the anterior petrosal, transcochlear, and retrosigmoid with suprameatal extension were performed. For endoscopic endonasal approaches, the transclival approach was performed in the midline of 5 specimens and its contralateral transmaxillary extension was performed on 10 sides. RESULTS: The anterior petrosal approach offers an anterolateral view of the PA bounded by petrous ridge posteromedially, internal auditory canal posterolaterally, greater superficial petrosal nerve anterolaterally, and lateral boundary of cranial nerve V, the Gasserian ganglion, and V3 anteromedially; it exposes the middle fossa and, once the PA is removed, the superomedial cerebellopontine angle. The transcochlear approach affords a lateral view of the PA defined medially and inferiorly by inferior petrosal sinus, posteriorly by posterior fossa dura, anteriorly by the petrous internal carotid artery, and superiorly by the superior petrosal sinus and middle fossa dura. Through a retrosigmoid approach, the PA is bounded by the superior petrosal sinus superiorly, the sagittal plane of cranial nerve VI medially, and the axial and sagittal plane of the internal auditory canal porus inferiorly and laterally, respectively. It affords a panoramic view of the posterior fossa and access to Meckel's cave after PA drilling. Endoscopic endonasal approaches target the anteromedial PA, and it is demarcated by a triangle consisting of cranial nerve VI posterolaterally, the paraclival segment of the internal carotid artery anteriorly, and the petroclival synchondrosis inferiorly and medially. The addition of the contralateral transmaxillary approach enhances lateral access up to the internal auditory canal. CONCLUSION: We provide a comprehensive overview of the main approaches to the PA through illustrative anatomic dissections and representative cases.

BACKGROUND AND OBJECTIVES: The artery of Davidoff and Schechter (ADS) is a dural branch of the posterior cerebral artery, supplying the falcotentorial junction. It is not commonly depicted on angiography due to its small size; thus, its visibility is usually indicative of a pathology, such as a dural arteriovenous fistula (DAVF). Recognizing the ADS as a feeder could be vital in enhancing management success, and understanding its anatomy is important for preventing complications during embolization or microsurgery. We present a scoping review of DAVFs fed by the ADS followed by an illustrative case report encountered at our institution. METHODS: An extensive literature review was conducted using PubMed, Embase, Web of Science, Scopus, and Cochrane databases. The search included the keywords: “Davidoff,” “Schechter,” “Davidoff and Schechter,” “dural branch,” “tentorial branch,” “medial branch,” and “meningeal branch,” in combination with “arteriovenous fistula,” “posterior cerebral artery,” and “superior cerebellar artery.” Only articles published in English or Spanish were included, with no restriction on publication date. Case reports and series were further screened based on best relevance. Data extraction and synthesis were performed in accordance with Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. RESULTS: A total of 16 articles describing 32 cases of DAVFs supplied by the ADS were identified. The most common onset was headache (43.8%), followed by altered mental status (21.2%). Most DAVFs were classified as high grade based on Borden/Cognard scales. Transarterial embolization was the most used treatment (81.3%), achieving complete occlusion in 76.9% of cases. Among patients with complete occlusion, approximately half experienced full resolution of symptoms. In a mean follow-up of 27.4 months (IQR: 30), 2 cases reported complications due to reflux of the embolic agent. CONCLUSION: A comprehensive understanding of the ADS's angioarchitecture is essential to take full advantage of this artery's features in the treatment, mitigating potential complications and optimizing patient outcomes.

Thalamic neuromodulation has re-emerged as a central strategy for the treatment of drug-resistant epilepsy, driven by advances in stereo-electroencephalography, network neuroscience, and signal processing. This perspective paper summarizes and integrates the key scientific, technical, and clinical insights presented during the American Epilepsy Society (AES) 2025—Epilepsy Surgery Symposium on Advances in Thalamic Neuromodulation for Epilepsy: From Mechanisms of Action to Clinical Application . Beyond a summary of the individual presentations, this manuscript reflects the collective opinions of the panel regarding current evidence, unresolved controversies, and future directions. An unifying theme emerged: effective thalamic neuromodulation requires a shift from empiric, one-size-fits-all targeting toward patient-specific, hodology-informed strategies grounded in in situ electrophysiology and network-level biomarkers.