Mayo Clinic - AuthorCitation

MOG Antibody–Associated Disease in the Setting of Metastatic Melanoma Complicated by Immune Checkpoint Inhibitor Use

Zhao-Fleming, Hannah , Guo, Yong , Tisavipat, Nanthaya , Chen, John J. , Ζεκερίδου, Αναστασία , Kournoutas, Ioannis , Orme, Jacob J. , Block, Matthew S. , Lucchinetti, Claudia F. , Syc-Mazurek, Stephanie B , Guo, Yong , Tisavipat, Nanthaya , Chen, John J , Zekeridou, Anastasia , Mustafa, Rafid , Flanagan, E P , Syc‐Mazurek, Stephanie B. , Mustafa, Rafid , Flanagan, Eoin P.

Neurology Neuroimmunology & Neuroinflammation | May 2, 2024 | Volume: 11 | Issue: 4 | Pages: No page available

10.1212/nxi.0000000000200249 | PMID 38696737

Proteomics of CT Emphysema Subtypes. The Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)

Guzman, Daniel E., Ruvuna, L. , Guo, C. , Sun, Yifei , Bertoni, A., Allen, N.B., Durda, Peter, Kent, Toby, Liu, Yixian , Johnson, W. Craig , Gerszten, Robert E. , Watson, Karol E., HOESTEREY, DANIEL , Hoffman, E.A., Bleecker, Eugene R. , Han, M.K. , Hansel, Nadia N. , Pratte, Katherine , Hastie, Annette T. , Laine, Andrew F. , Ortega, Victor E. , Paine, Robert , Curtis, J.L., Silverman, Edwin K. , Woodruff, P., Bowler, R.P., Smith, Benjamin M. , Post, Wendy S. , Kent, T., Tracy, Russell P. , Pankow, James S. , Manichaikul, Ani , Hoffman, E.A., Angelini, Elsa D. , Barjaktarević, Igor , Couper, David , Krishnan, Jerry A , Labaki, Wassim W. , Martínez, Fernando J. , Wells, J. Michael , Curtis, J.L., Rich, Stephen S. , Rotter, Jerome I. , Barr, R. Graham

A29. WHAT IS YOUR DAMAGE? IMAGING-BASED PHENOTYPES OF COPD | April 30, 2024 | Volume: No volume available | Issue: No issue available | Pages: A1254-A1254

10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a1254

Paraneoplastic Calmodulin Kinase‐Like Vesicle‐Associated Protein (CAMKV) Autoimmune Encephalitis

Gilligan, Michael , Lesnick, Connie , Guo, Yong , Nowak, Mihaela, Shah, Maulik , Wittenborn, J. R., Basal, Eati, Hinson, Shannon R., Yang, Binxia , Dubey, Divyanshu , Mills, John R. , Pittock, Sean J. , Ζεκερίδου, Αναστασία , Dubey, Divyanshu , Pittock, S J , Lesnick, Connie E, Bradshaw, Michael , Hinson, Shannon, Dubey, Divyanshu , Zekeridou, Anastasia , McKeon, Andrew , Dubey, Divyanshu , Gilligan, Michael , Ladha, Shafeeq , Wittenborn, John R., Yang, Binxia , McKeon, Andrew

Annals of Neurology | April 18, 2024 | Volume: 96 | Issue: 1 | Pages: 21-33

10.1002/ana.26943 | PMID 38634529

ObjectivesTo report an autoimmune paraneoplastic encephalitis characterized by immunoglobulin G (IgG) antibody targeting synaptic protein calmodulin kinase‐like vesicle‐associated (CAMKV).MethodsSerum and cerebrospinal fluid (CSF) samples harboring unclassified antibodies on murine brain‐based indirect immunofluorescence assay (IFA) were screened by human protein microarray. In 5 patients with identical cerebral IFA staining, CAMKV was identified as top‐ranking candidate antigen. Western blots, confocal microscopy, immune‐absorption, and mass spectrometry were performed to substantiate CAMKV specificity. Recombinant CAMKV‐specific assays (cell‐based [fixed and live] and Western blot) provided additional confirmation.ResultsOf 5 CAMKV‐IgG positive patients, 3 were women (median symptom‐onset age was 59 years; range, 53–74). Encephalitis‐onset was subacute (4) or acute (1) and manifested with: altered mental status (all), seizures (4), hyperkinetic movements (4), psychiatric features (3), memory loss (2), and insomnia (2). Paraclinical testing revealed CSF lymphocytic pleocytosis (all 4 tested), electrographic seizures (3 of 4 tested), and striking MRI abnormalities in all (mesial temporal lobe T2 hyperintensities [all patients], caudate head T2 hyperintensities [3], and cortical diffusion weighted hyperintensities [2]). None had post‐gadolinium enhancement. Cancers were uterine adenocarcinoma (3 patients: poorly differentiated or neuroendocrine‐differentiated in 2, both demonstrated CAMKV immunoreactivity), bladder urothelial carcinoma (1), and non‐Hodgkin lymphoma (1). Two patients developed encephalitis following immune checkpoint inhibitor cancer therapy (atezolizumab [1], pembrolizumab [1]). All treated patients (4) demonstrated an initial response to immunotherapy (corticosteroids [4], IVIG [2]), though 3 died from cancer.InterpretationCAMKV‐IgG is a biomarker of immunotherapy‐responsive paraneoplastic encephalitis with temporal and extratemporal features and uterine cancer as a prominent oncologic association. ANN NEUROL 2024;96:21–33

Recessively Inherited Deficiency of Secreted WFDC2 (HE4) Causes Nasal Polyposis and Bronchiectasis

Dougherty, Gerard W. , Ostrowski, Lawrence E. , Nöthe-Menchen, Tabea , Schramm, Andre, Olbrich, Heike , Yin, Weining, Sears, Patrick R. , Smith, Amanda , Beule, Achim G. , Rutjes, Niels W. , Haarman, Eric G. , Maas, Saskia M. , Ferkol, Thomas W. , Noone, Peadar G. , Olivier, Kenneth N., Bracht, Diana , Fierville, Morgane , Wohlgemuth, Kai , König, Julia, George, Sebastian , Loges, Niki T. , Ceppe, Agathe , Rizk, Hoda, El-Desoky, Tarek , Dahlke, Katrin , Boldt, Karsten , Pang, Yuan‐Ping , Knowles, Michael R. , Zariwala, Maimoona A., Zariwala, Maimoona A. , Olivier, Kenneth N , Barbry, Pascal , Zaragosi, Laure-Emmanuelle , Luo, Hong , Zariwala, Maimoona A , Omran, Heymut , Pang, Yuan-Ping , Raidt, Johanna , Dang, Hong , Hjeij, Rim , Zaragosi, Laure‐Emmanuelle , Kliesch, Sabine , Markovetz, Matthew R. , Guo, Ting , Rizk, Hoda, Ueffing, Marius , Hill, David B. , Omran, Heymut

American Journal of Respiratory and Critical Care Medicine | April 16, 2024 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.1164/rccm.202308-1370oc | PMID 38626355