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Accuracy and reliability of determining the isometric point of the knee for multiligament knee reconstruction
Leiter, Jeff , Levy, Bruce A. , Stannard, James P. , Whelan, Daniel B. , Marx, Robert G. , Boyd, Joel L. , MacDonald, Peter B. , Fanelli, Gregory C. , Stuart, Michael J.

Knee Surgery, Sports Traumatology, Arthroscopy | October 5, 2013 | Volume: 22 | Issue: 9 | Pages: 2187-2193

10.1007/s00167-013-2661-2 | PMID 24096377 Get It

AbstractPurposeTo compare the accuracy and reliability of the anatomic and radiographic techniques for identifying the isometric point of the knee.MethodsOnly four specimens were used; however, eight experienced multiligament knee injury surgeons were recruited to address this limitation. Surgeons estimated the isometric point (EIP) on the medial and lateral sides using an anatomic and radiographic method. The x and y coordinates of the EIP were compared to the true isometric point (TIP). T‐tests and interclass correlation coefficients (ICC) were performed to determine the accuracy and reliability between the methods.ResultsThere was no difference in placement of the EIP on the medial side of the knee in the anterior/posterior (x; p = n.s.) and superior/inferior direction (y;p = n.s). The EIP was anterior (p = 0.001) to the TIP with the radiographic method on the lateral side and approached significance (p = 0.05) in the superior/inferior direction. The ICC (95 % CI) for identifying the EIP on the medial side in the anterior/posterior direction using the anatomic method was 0.64 (0.28–0.96) and 0.11 (−0.06 to 0.77) in the superior/inferior direction. Using the radiographic method, the ICC in the anterior/posterior and superior/inferior direction was 0.49 (0.14–0.94) and 0.15 (−0.47 to 0.81), respectively. On the lateral side, the ICC for the anatomic method was 0.84 (0.56–0.99) in the anterior/posterior direction and 0.36 (0.05–0.90) in the superior/inferior direction. Using the radiographic method, the ICC in the anterior/posterior and superior/inferior direction was 0.61 (0.26–0.96) and 0.89 (0.67–0.99), respectively.ConclusionsThere was no difference in accuracy on the medial side of the knee. On the lateral side, the anatomic method was more accurate in the anterior/posterior direction. Reliability was greater in the anterior/posterior direction on both sides of the knee. Surgeons were most likely to place the isometric point anterior and superior to the TIP on both the medial and lateral sides of the knee with either method which has the potential to cause graft lengthening. This should be taken into consideration during reconstruction/repair of the MCL/PMC and LCL/PLC.
Surgery for Recurrent Colon Cancer: Strategies for Identifying Resectable Recurrence and Success Rates after Resection
Goldberg, Richard M., Fleming, Thomas R., Tangen, Catherine M., Moertel, Charles G., Macdonald, John S., Haller, Daniel G., Laurie, John A., Fleming, Thomas R., Tangen, Catherine M., Moertel, Charles G., Macdonald, John S., Haller, Daniel G., Laurie, John A.

Annals of Internal Medicine | April 12, 2013 | Volume: 129 | Issue: 1 | Pages: 27-35

10.7326/0003-4819-129-1-199807010-00007 | PMID 9652996 Get It

Hip and knee arthroplasty 2011
Rosenberg, Aaron G., Berend, Michael E. , Berry, Daniel J. , Valle, Craig J. Della , MacDonald, Steven J. , Minas, T., Berry, Daniel J

The Journal of Bone and Joint Surgery. British volume | November 1, 2012 | Volume: 94-B | Issue: 11_Supple_A | Pages: 157-166

10.1302/0301-620x.94b11.30511 | PMID 23118407 Get It

This conversation represents an attempt by several arthroplasty surgeons to critique several abstracts presented over the last year as well as to use them as a jumping off point for trying to figure out where they fit in into our current understanding of multiple issues in modern hip and knee arthroplasty.
Probing the Peripheral Site of Human Butyrylcholinesterase
Macdonald, Ian R. , Martin, Earl , Rosenberry, Terrone L. , Darvesh, Sultan

Biochemistry | August 17, 2012 | Volume: 51 | Issue: 36 | Pages: 7046-7053

10.1021/bi300955k | PMID 22901043 Get It

Primary leptomeningeal lymphoma
Lachance, D. H., Macdonald, David R., Jaeckle, Kurt A. , Witzig, T.E. , Li, C.-Y., Posner, J. B., O’Neill, Brian Patrick

Neurology | May 13, 2012 | Volume: 41 | Issue: 1 | Pages: 95-95

10.1212/wnl.41.1.95 | PMID 1985302 Get It

CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion
Lee, J.-M., Ramos, E.M., Lee, J.-H., Gillis, Tammy , Mysore, Jayalakshmi Srinidhi, Hayden, Michael R. , Warby, Simon C. , Morrison, PJ, Nance, Martha , Ross, Christopher A. , Margolis, Russell L. , Squitieri, Ferdinando , Orobello, S., Donato, Stefano Di , Gómez‐Tortosa, Estrella , Ayuso, Carmen , Suchowersky, Oksana , Trent, R J, McCusker, Elizabeth, Novelletto, Andrea , Frontali, Marina , Jones, Randi, Ashizawa, Tetsuo , Saint‐Hilaire, Marie , Hersch, Steven M. , Rosas, H. Diana , Lucente, Diane , Harrison, Madeline, Zanko, Andrea, Abramson, Ruth K., Marder, Karen, Sequeiros, Jorge , Paulsen, Jane S. , Landwehrmeyer, G. Bernhard , Myers, Richard H. , MacDonald, Marcy E., Gusella, James F. , Frati, Luigi, Perlman, Susan B. , Conneally, P. M., Klimek, Mary Lou, Diggin, Melissa, Hadzi, Tiffany C., Duckett, Ayana, Ames, David, Anderson, Christine, Anderson, Karla J., Anderson, Karen, Andrews, Thomasin, Axelson, Eric, Aylward, Elizabeth , Barker, Roger A. , Barth, Katrin, Barton, Stacey K. , Baynes, Kathleen, Bea, Alexandra, Beglinger, Leigh J., Biglan, Kevin , Björk, K., Blanchard, Steve, Bockholt, Jeremy , Bommu, Sudharshan Reddy, Brossman, Bradley G., Burrows, Maggie, Calhoun, Vince D. , Carlozzi, Noelle E. , Chesire, Amy M., Chiu, Edmond, Connell, R.J., Connor, Carmela, Corey‐Bloom, Jody , Craufurd, David, Cross, Stephen, Santos, Rachelle Dar, Davis, Jennifer , Decolongon, Joji, Dipietro, A., Doucette, Nicholas, Downing, Nancy R. , Dudler, Ann, Ecker, Daniel, Erickson, Diane, Erwin, Cheryl , Farias, Sarah Tomaszewski , Fatas, Marta, Fullam, Ruth, Furtado, Sarah , Garde, Mónica Bascuñana, Geschwind, Michael D., Gooblar, Jon, Goodman, Anna , Griffith, Jane, Groves, Mark, Guttman, Mark, Hamilton, Joanne M., Harris, Greg, Heaton, Robert K. , Helmer, Karl, Henneberry, Machelle, Herwig, Kelly, Howard, Elizabeth, Hunter, Christine , Jankovic, Joseph, Johnson, Hans J. , Johnson, Arik, Jones, Kathy, Kimble, Mycah, King, Pamela, Klöppel, Stefan , Komiti, Angela , Kumar, Rajeev , Leavitt, Blair, Leserman, Anne, Lipe, Hillary, Lowe, Mark J. , Magnotta, Vincent A. , Mallonee, William, Mans, Nicole , Marietta, Jacquie, Marshall, Frederick J., Mason, Sarah, Matheson, Kirsty, Matson, Wayne R., McDowell, William , Miedzybrodzka, Zosia , Mills, James A. , Miracle, Dawn, Montross, Kelsey, Moore, David D. , Mori, S., Moskowitz, Carol, Newman, Emily R., Novak, Marianne, O’Rourke, Justin J. F., Oakes, David , Ondo, William G. , Orth, Michael, Pease, Karen R., Perlmutter, Joel, Peterson, Asa , Pierson, Ron, Preston, J. Samuel, Quaid, Kimberly A., Radtke, Dawn, Rae, D. O., Raymond, Lynn A. , Reading, Sarah, Ready, Rebecca E. , Reece, Christine, Reynolds, Norm, Richardson, Kylie, Rickards, Hugh , Ro, Eunyoe , Rodnitzky, Robert L., Rosser, Elisabeth, Rosser, Anne, Price, Kathy, Price, Kathy, Ryan, Pat, Salmon, David P. , Samii, Ali, Schumacher, Jamy, Sendon, Jose Luis Lópenz, Shear, Paula K. , Sheinberg, Alanna, Shpritz, Barnett, Simpson, Sheila A., Singer, Adam D. , Smith, Megan M. , Snyder, Pete, Song, Allen W. , Sran, Satwinder, Stober, Janice, muth, Sigurd Sü, Suter, Greg, Tabrizi, Sarah J. , Tempkin, Terry, Thompson, Sean , Thomsen, Teri, Thumma, Kelli, Trautmann, Sonja, Tremont, Geoff, Turner, Jessica A. , Uc, Ergun, Duijn, E. van, Walsem, Marleen van, Vik, Stacie , Vonsattel, Jean Paul, Vuletich, Elizabeth J., Warner, Tom, Wasserman, Paula, Waterman, Elijah, Weaver, Kurt E. , Weir, David , Werling-Witkoske, Chris, Wesson, Melissa, Westervelt, Holly James , Weydt, Patrick , Wheelock, Vicki, Wodarski, Mary, Wojcieszek, Joanne, Wood, Jessica, Wood‐Siverio, Cathy, Wu, Shuhua , Yastrubetskaya, Olga, Yébenes, Justo García de, Zhao, Yong Qiang, Zimbelman, Janice L., Zschiegner, Roland, Aaserud, Olaf, Abbruzzese, Giovanni , Andrews, Thomasin, Andrich, Jurgin, Antczak, Jakub , Arran, Natalie, Artiga, María José Saiz, Bachoud‐Lévi, Anne‐Catherine , Banaszkiewicz, Krysztof, Barberá, Miguel Aguilar, Barrero, Francisco Javier , Bas, Jordi, Beister, Antoine, Bertini, Elisabetta, Biunno, Ida , Bjørgo, Kathrine, Bjørnevoll, Inga, Bohlen, Stefan, Bonelli, Raphael M., Bos, Reineke, Bourne, Colin, Bradbury, Alyson, Brockie, Peter, Brown, Felicity, Buck, Andrea, Burg, Sabrina, Burgunder, Jean‐Marc , Burns, Peter, Burrows, Liz, Calopa, Matilde , Carruesco, Gemma Tome, Casado, Ana Gonzalez, Catena, Judit López, Chu, Carol , Clapton, Jackie, Clayton, Carole, Clenaghan, Catherine, Connemann, Julia, Crooks, Jenny, Cubillo, Patricia Trigo, Cubo, Esther , Curtis, Adrienne, Michele, Giuseppe De , Souza, Jenny de, Weert, A. Marit de, Dekker, M., Descals, Asunción Martínez, Maio, Luigi Di, Pietro, Anna Di, Dipple, Heather, Dose, M., Dumas, Eve M., Dunnett, Stephen B. , Elifani, Francesca , Ellison-Rose, Lynda, Elorza, Marina D., Eschenbach, Carolin, Evans, Carole, Fairtlough, Helen, Fannemel, Madelein, Fenollar, María del Mar, Ferrandes, Giovanna, Ferreira, Jaoquim J., Fillingham, Kay, Finisterra, Ana Maria, Fisher, Kate , Fletcher, Amy, Foster, Jillian, Foustanos, Isabella, Frech, Fernando Alonso, Fullam, Robert, Fullham, Ruth, Gago, Miguel , García, R. de Francisco, García, Socorro S., Garrett, Carolina, Gellera, Cinzia , Gill, Paul R., Ginestroni, Andrea, Golding, Charlotte, Gørvell, Per F., Griguoli, Anna Maria, Gross, Diana, BascuñanaGuerra, Monica, Guerra, Maria Rosália, Guerrero, Rosa , Guía, D. Badenes, Guidubaldi, Arianna, Hallam, Caroline, Hamer, Stephanie, Hammer, K., Handley, Olivia, Harding, Alison, Hasholt, Lis, Hedge, R.M., Heiberg, Arvid, Heinicke, Walburgis, Held, Christine, Hernanz, Laura Casas, Herranhof, Briggitte, Hiivola, Heli, Hjermind, Lena E. , Hobson, Emma, Hoffmann, Rainer , Holl, Anna, Howard, Liz Livingston, Huson, Susan, Ialongo, Tàmara, Idiago, Jesús Miguel Ruiz, Illmann, Torsten, Jachińska, Katarzyna, Jacopini, Gioia, Jakobsen, Oda, Jamieson, Stuart W., Jamrozik, Zygmunt , Janik, Piotr , Johns, Nicola, Jones, Lesley , Jones, Una , Jurgens, Caroline K., Kaelin‐Lang, Alain , Kershaw, Ann, Kieni, Janina, Koivisto, Susana Pro, Koppers, Kerstin, Kosinski, Christoph M., Kremer, Berry, Krysa, Wioletta, Kwieciński, Hubert, Lahiri, Nayana , Lambeck, Johann , Lange, Herwig W. , Laver, Fiona, Levey, Jamie, Leythaeuser, Gabriele, Lezius, Franziska , Llesoy, Joan Roig, Löhle, Matthias , López, Cristobal Diez-Aja, Lorenza, Fortuna, Loria, G, Magnet, Markus, Mandich, Paola , Mariotti, Caterina , Mariscal, Natividad, Marková, Ivana S. , Marquard, Ralf, Martikainen, Kirsti, Martínez, Isabel Haro, Martínez‐Descals, Asunción, Martino, T., Mason, Sarah, McKenzie, Sue, Mechi, Claudia, Middleton, Julia, Milkereit, Eva, Miller, Julie, Minster, Sara, Möller, Jens Carsten , Monza, Daniela, Morales, Blas, Moreau, Laura V., Murch, Ann, Niess, Anke, Nørremølle, Anne , O'Donovan, Kristy, Orth, Michael, Otti, Daniela, Padieu, Hélène, Paganini, M. , Painold, Annamaria , Päivärinta, Markku, Partington-Jones, Lucy, Paterski, Laurent, Paterson, Nicole D., Patino, Dawn Freire-, Patton, Michael J. , Peinemann, Alexander, Peppa, Nadia , Perea, María Fuensanta Noguera, Peterson, Maria, Càrdenas, Regina Pons i, Prehn, Christian, Price, Kathleen, Probst, Daniela, Quiroga, Purificacion Pin, Raab, Tina, Rakowicz, Maryla, Raman, Ashok, Raymond, Lucy, Reinante, Gema, Retterstøl, Lars, Ribaı̈, Pascale, Riballo, Antonio Villa, Ribas, Guillermo García, Rinaldi, Carlo , Rissling, Ida, Rivera, Susana Vázquez , Robert, Misericordia Floriach, Roca, Elvira, Romano, Silvia , Romoli, Anna Maria , Roos, Raymond A.C., Røren, Niini, Rosser, Anne, Rossi, F., Rothery, Jean, Ruíz, Belan Garzon, Russo, Cinzia Valeria , Ryglewicz, Danuta , Saft, Carston, Sánchez, Vicenta , Sando, Sigrid Botne , Šašinková, Pavla, Saß, Christian, Scheibl, Monika, Schiefer, Johannes, Schlangen, Christiane, Schöggl, Helmut, Schrenk, Caroline, Schüpbach, Michaël , Schuierer, Michele, Sebastián, Ana Rojo, Selimbegovic-Turkovic, Amina, Sempołowicz, Justyna, Silva, Mark, Sławek, Jarosław , Snowden, Julie S. , Soleti, Francesco, Sollom, Andrea, Sołtan, Witold, Sorbi, Sandro , Sørensen, Sven Asger, Spadaro, M., Städtler, Michael, Stamm, Christiane, Steiner, Tanja, Stokholm, Jette, Stokke, Bodil, Storch, Alexander , Straßburger, Katrin, Stubbe, Lars, Szczudlik, Andrzej, Taylor, Rachel , Terol, Santiago Duran-Sindreu, Thomas, Gareth, Thomson, Aileen, Tidswell, Katherine, Torres, María Martirio Antequera, Toscano, Jean, Townhill, Jenny, Tucci, Tecla, Tuuha, Katri, Uhrová, Tereza , Valadas, Anabela , Hout, Monique S.E. van, Oostrom, Joost C.H. van, Vugt, Jeroen P.P. van, vanm, Walsem Marleen R., Vandenberghe, Wim , Verellen‐Dumoulin, Christine, Vergara, M, Verstappen, C.C.P., Verstraelen, Nichola , Viladrich, Cèlia Mareca, Villanueva, Clara , Wahlström, Jan , Wehus, R., Weindl, A., Westmoreland, Leann, Wiedemann, Alexandra, Wild, Edward J. , Wild, Sue, Witjes‐Ané, Marie‐Noëlle W. , Witkowski, Grzegorz , Wójcik-Pędziwiatr, Magdalena , Wolz, Martin , Wolz, Annett, Wright, Jan, Yardumian, Pam, Yates, Shona, Yudina, Elizaveta, Zaugg, Sabine Weber, Zdzienicka, Elżbieta, Zielonka, Euginiusz, Zinzi, Paola , Zucker, B., Adams, John , Antonijevic, Irina , Beck, Christopher A. , Chiu, Edmond, Churchyard, Andrew, Colcher, Amy, Dorsey, Ray, Drazinic, Carolyn, Dubinsky, Richard , Duff, Kevin, Giuliano, Joe, Greenamyre, Timothy, Jennings, Dana, Kang, Un Jung , Kumar, Rajeev, Leavitt, Blair, LeDoux, Mark S. , Mohlo, Eric, Morgan, John C. , Panisset, Michel , Perlmutter, Joel, Revilla, Fredy J., Robertson, Suzanne, Robottom, B., Scott, B.L. , Shoulson, Ira , Singer, Carlos , Tabbal, Samer D., van, Kammen Dan, Vetter, Louise, Walker, Francis O. , Warner, John Harley , Weiner, illiam, Broyles, Janice, Clouse, Ronda, Coleman, Allison, Davis, Robert E. , de-la-Rosa, J.-L., Deuel, Lisa M., Dietrich, Susan, Dubinsky, Hilary, Eaton, Ken, Erickson, Diane, Fitzpatrick, Mary Jane, Frucht, Steven J. , Gartner, Maureen, Goldstein, Jody, Hickey, Charlyne, Hunt, Victoria, Jaglin, Jeana, Lindsay, Pat, Louis, Elan D. , Loy, Clemet, Lucarelli, N., Malarick, Keith, Martin, Amanda, McInnis, Robert , Nucifora, Frederick C. , Palao, Alicia, Peavy, Guerry M. , Quesada, Mónica, Schmidt, Amy P., Segro, Vicki, Sperin, Elaine, Tanev, Kalo, Tempkin, Teresa, Thiede, Curtis, Zauber, Elizabeth, Ferreira, Joaquim J. , Vivancos, L. , Frank, Samuel , Dürr, Alexandra , Rosenblatt, Adam E , Ahmed, Anwar E. , Allen, Paul D. , Anderson, Christine, Ashburner, John , Beall, Erik B. , Beg, Mirza Faisal , Calhoun, Vince D. , Chua, Phyllis M-L. , Cysique, Lucette A. , Dunn, Steve , Epping, Eric A. , Evans, Kenneth , Factor, Stewart Alan , Fiedorowicz, Jess G. , Gehl, Carissa , Goh, Anita , Gooblar, Jonathan, Harrington, Deborah Lynn , Hershey, Tamara G. , Jankovic, Joseph, Johnson, Arik, Juhl, Andrew R. , Kim, Eun Young , Koenig, Katherine A. , Langbehn, Douglas R. , Leavitt, Blair, Lim, Kelvin O. , Martin, W. R. Wayne , Mason, Sarah, Mazzoni, Pietro , Miller, Michael I. , Moser, David J. , Nopoulos, Peg , Orth, Michael, Panegyres, Peter K. , Perlmutter, Joel, Phillips, Michael , Potkin, Steven G. , Rao, Stephen M. , Reilmann, Ralf , Robinson, Robert A. , Rogers, Benedict D. , Rosser, Anne, Price, Kathy, Price, Kathy, Schumacher, Jessica R. , Siedlecki, Karen L. , Smith, Jim Q. , Smith, Glenn E. , Stephan, Klaas Enno , Testa, Claudia M. , Toga, Arthur W. , Uc, Ergun, Vaccarino, Anthony L. , Warner, Tom, Wassink, Thomas H. , Welsh, Claire E. , Williams, Kent C. , Williams, Janet K. , Wood, Jessica, Andrews, Thomasin, Poggio, M. , Bandmann, Oliver , Bentivoglio, Anna Rita , Bruno, Stefania , Bryl, Anna , Busquets, Núria , Busse, Monica E , Ciesielska, Anna , Coelho, Miguel M , Nicola, Antonio De , Fannemel, Madeleine , Fasano, Alfonso , Grant, Janet F. , Guedes, Leonor Correia , Herranhof, Brigitte, Herrera-Espiñeira, Carmen , Hidding, Ute , Hill, Susan , Hunt, Sarah E , Kalbarczyk, Anna , Khalil, Hanan W. , Klimberg, Aneta , Krawczyk, Małgorzata Anna , Kremer, Berry P. H., Leenders, Klaus Leonhard , Marchese, Roberta , Marcinkowski, T , Mason, Sarah, Mendes, Tiago , Mestre, Tiago , Miller, J. Philip , Moreau, Laura V., López-Sendón, José Luis , Münchau, Alexander Maximilian , Nielsen, Jørgen Erik , Orth, Michael, Owen, Michael J. , Freire-Patino, Dawn, Piacentini, Silvia , Piano, Carla , Quarrell, Oliver , Rakowicz, Maryla, Reisinger, Karin M. , Richter, Sven , Ritchie, Stuart James , Rose, Sarah , Rosser, Anne, Rudzińska, Monika , Ruiz, Pedro , Saft, Carston, Salvatore, Elena , Schmidt, Simone Bianca , Sitek, Emilia J. , Soliveri, Paola , Stopford, Cheryl L. , Sułek, Anna , Thompson, J. C. , Warner, Thomas T. , Werner, Cornelius Johannes , Zaremba, Jacek , Zielonka, Daniel , Zittel, Simone , Agarwal, Pinky , Chiu, Edmond, Duff, Kevin, Foroud, Tatiana , Greenamyre, Timothy, Higgins, Donald S. , Kostyk, Sandra K. , Kumar, Rajeev, Leavitt, Blair, Perlmutter, Joel, Sanchez‐Ramos, Juan , Shannon, Kathleen M. , Erickson, Diane, Muratori, Lisa M. , O’Neill, Christine J. , Turner, Jessica A , Ross, Christopher A , Ferreira, Joaquim J , Sławek, Jarosław , Magnotta, Vincent A

Neurology | February 9, 2012 | Volume: 78 | Issue: 10 | Pages: 690-695

10.1212/wnl.0b013e318249f683 | PMID 22323755 Get It

Teaching Neuro Images : Traumatic vertebral arteriovenous fistula
Boot, Brendon , Macdonald, Jason, Parker, Geoffrey , Jankelowitz, Stacey

Neurology | February 15, 2011 | Volume: 76 | Issue: 7 | Pages: No page available

10.1212/wnl.0b013e31820c2eaa | PMID 21321330 Get It

Definition of Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage as an Outcome Event in Clinical Trials and Observational Studies
Vergouwen, Mervyn D. I. , Vermeulen, Marinus, Gijn, J. van , Muizelaar, J. Paul, Mendelow, A. D. , Juvela, Seppo , Yonas, Howard, terBrugge, Karel G. , Macdonald, R. Loch , Diringer, Michael N. , Broderick, Joseph P., Dreier, Jens P. , Roos, Yvo B.W.E.M. , Rinkel, Gabriël J.E. , Wijdicks, Eelco F. M. , Broderick, Joseph

Stroke | August 26, 2010 | Volume: 41 | Issue: 10 | Pages: 2391-2395

10.1161/strokeaha.110.589275 | PMID 20798370 Get It

Background and Purpose— In clinical trials and observational studies there is considerable inconsistency in the use of definitions to describe delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage. A major cause for this inconsistency is the combining of radiographic evidence of vasospasm with clinical features of cerebral ischemia, although multiple factors may contribute to DCI. The second issue is the variability and overlap of terms used to describe each phenomenon. This makes comparisons among studies difficult. Methods— An international ad hoc panel of experts involved in subarachnoid hemorrhage research developed and proposed a definition of DCI to be used as an outcome measure in clinical trials and observational studies. We used a consensus-building approach. Results— It is proposed that in observational studies and clinical trials aiming to investigate strategies to prevent DCI, the 2 main outcome measures should be: (1) cerebral infarction identified on CT or MRI or proven at autopsy, after exclusion of procedure-related infarctions; and (2) functional outcome. Secondary outcome measure should be clinical deterioration caused by DCI, after exclusion of other potential causes of clinical deterioration. Vasospasm on angiography or transcranial Doppler can also be used as an outcome measure to investigate proof of concept but should be interpreted in conjunction with DCI or functional outcome. Conclusion— The proposed measures reflect the most relevant morphological and clinical features of DCI without regard to pathogenesis to be used as an outcome measure in clinical trials and observational studies.