Citations 2
DNA methylation at the vicinity of the proximal polyadenylation site in FANCD2 gene involves human malignancy
Ma, Chi , Wang, Zhanwei , Nepal, Manoj , Hokutan, Kanani , Zhang, Jun , Fei, Peiwen, Yu, Kai
Cell Cycle | September 3, 2018 | Volume: 17 | Issue: 17 | Pages: 2204-2206
FANCD2 and DNA Damage
Nepal, Manoj , Che, Raymond , Ma, Chi , Fei, Peiwen, Zhang, Jun
International Journal of Molecular Sciences | August 21, 2017 | Volume: 18 | Issue: 8 | Pages: 1804
Investigators have dedicated considerable effort to understanding the molecular basis underlying Fanconi Anemia (FA), a rare human genetic disease featuring an extremely high incidence of cancer and many congenital defects. Among those studies, FA group D2 protein (FANCD2) has emerged as the focal point of FA signaling and plays crucial roles in multiple aspects of cellular life, especially in the cellular responses to DNA damage. Here, we discuss the recent and relevant studies to provide an updated review on the roles of FANCD2 in the DNA damage response.