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Kot, Timur L.

Mayo Clinic

Khanty‐Mansiysk Clinical Psychoneurological Hospital Khanty‐Mansiysk Russia

Citations 1

Solar insolation in springtime influences age of onset of bipolar I disorder
Bauer, Michael , Glenn, Tasha , Aleksandrovich, M. A., Angelopoulos, Elias, Ardau, Raffaella , Ayhan, Yavuz , Baethge, Christopher , Bharathram, S. R., Bauer, Rita, Becerra‐Palars, C., Belmaker, Robert H. , Berk, Michael , Bersudsky, Yuly, Bicakci, Ş., Bjella, Thomas , Bossini, Letizia, Cabrera, Jorge , Cheung, Eric Yat Wo, Zompo, Maria Del , Donix, Markus , Étain, Bruno , Fountoulakis, Konstantinos Ν. , Frye, Mark A. , González‐Pinto, Ana , Gottlieb, John F. , Grof, Paul , Harima, Hirohiko, Henry, Chantal , Isometsä, Erkki , Janno, Sven , Kapczinski, Flávio , Kardell, Mathias, Khaldi, S., Kliwicki, Sebastian , Kot, Timur L., Krogh, Rikke, Kunz, Maurício , Lafer, Beny , Landén, Mikael , Larsen, Erik Roj , Lewitzka, Ute , Licht, Rasmus Wentzer , López‐Jaramillo, Carlos , Manchia, Mirko , Marsh, Wendy , Melle, Ingrid , Meza-Urzúa, Fátima, Ming, Mok Yee, Monteith, Scott , Morken, Gunnar , Mosca, Enrica, Muñoz, Rodrigo , Mythri, Starlin Vijay , Nacef, F., Nery, Fabiano G. , Nielsen, René Ernst , O’Donovan, Claire , Omrani, Adel, Osher, Yamima , Sørensen, Helle Østermark , Ouali, Uta , Ruiz, Yolanda Pica, Pilhatsch, Maximilian , Pinna, Marco , Ponte, Francisco Diego Rabelo da, Quiroz, Danilo , Ramesar, Raj , Rasgon, Natalie , Reddy, M. S., Reif, Andreas , Ritter, Philipp , Sagduyu, Kemal, Scippa, Ângela Miranda, Severus, Emanuel , Simhandl, Christian , Stein, Dan J. , Strejilevich, Sergio , Sulaiman, Ahmad Hatim , Suominen, Kirsi, Tagata, Hiromi , Tatebayashi, Yoshitaka , Vaaler, A. E., Veeh, Julia, Vieta, Eduard , Viswanath, Biju , Yoldi‐Negrete, María , Zetin, Mark, Zgueb, Yosra , Whybrow, Peter C., Bauer, M , Bellivier, F , Etain, B , Vieta, E , Alda, Martin , Andreassen, Ole A. , Baune, Bernhard , Bellivier, Frank , Bicakci, Ş., Birabwa‐Oketcho, Harriet , Dodd, Seetal , Fagiolini, Andrea , König, Barbara , MacQUEEN, GLENDA M. , Martínez‐Cengotitabengoa, Mónica , MUNOZ, RODRIGO A. , Nadella, R K , Rybakowski, Janusz K , Subramaniam, M , Tondo, Leonardo , Torrent, Carla , Vaaler, A. E., Stein, Dan J , López-Jaramillo, Carlos , Fountoulakis, Konstantinos N , Reif, Andreas , Viswanath, Biju , Berk, Michael , Manchia, Mirko , Ouali, U , Ritter, P , Strejilevich, S , Yoldi-Negrete, M

Acta Psychiatrica Scandinavica | July 19, 2017 | Volume: 136 | Issue: 6 | Pages: 571-582

10.1111/acps.12772 Get It

ObjectiveTo confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder.MethodData were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth‐cohort, family history, polarity of first episode and country physician density.ResultsThere was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth‐cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth‐cohort (all estimated coefficientsP< 0.001).ConclusionA large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LEDlighting, mobile devices backlit withLEDs) may influence adaptability to a springtime circadian challenge.