Viswanath, Biju
Mayo Clinic
National Institute of Mental Health and Neuro Sciences, Bengaluru, Karnataka, India.
Citations 2
Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder
Gutiérrez-Fragoso, Karina , Amare, Azmeraw T. , Adli, Mazda , Akiyama, Kazufumi , Akula, Nirmala , Ardau, Raffaella , Arias, Bárbara , Aubry, Jean‐Michel , Benabarre, Antonio , Bengesser, Susanne , Abesh, Bhattacharjee, Birner, Armin , Cearns, Micah , Cervantes, Pablo , Chillotti, Caterina , Cichon, Sven , Clark, Scott R. , Dalkner, Nina , Zompo, Maria Del , Forstner, Andreas J. , Frank, Josef , Frisén, Louise , Frye, Mark A. , Gard, Sébastien, Grof, Paul , Hsu, Yi‐Hsiang , Kahn, Jean‐Pierre, Kassem, Layla, Laje, Gonzalo, Landén, Mikael , Lavebratt, Catharina , Leckband, Susan G. , Maj, Mario , Mitjans, Marina , Mondimore, Francis M. , Nöthen, Markus M. , O’Donovan, Claire , Pisanu, Claudia , Potash, James B. , Richard-Lepouriel, Hélène , Roberts, Gloria , Schalling, Martin , Schweizer, Barbara , Severino, Giovanni , Shekhtman, Tatyana , Shilling, Paul D. , Shimoda, Kazutaka , Simhandl, Christian , Slaney, Claire , Stamm, Thomas , Streit, Fabian , Veeh, Julia, Witt, Stephanie H. , Zandi, Peter P. , Bauer, Michael , Herrera-Rivero, Marisol , Amare, Azmeraw , Arias, Bárbara , Biernacka, Joanna , Cearns, Micah , Chen, Hsi-Chung , Clark, Scott , Cruceanu, Cristiana , Czerski, Piotr , Del Zompo, Maria , DePaulo, J Raymond , Forstner, Andreas J , Frank, Josef , Frye, Mark , Fullerton, Janice M , Garnham, Julie , Grigoroiu-Serbanescu, Maria , Hashimoto, Ryota , Hauser, Joanna , Heilbronner, Urs , Hou, Liping , Hsu, YiHsiang, Jamain, Stéphane , Kelsoe, John R , Kuo, Po-Hsiu , Kusumi, Ichiro , Landén, Mikael , Lavebratt, Catharina , Leboyer, Marion , Marie-Claire, Cynthia , Nievergelt, Caroline M , Novak, Tomas , Nöthen, Markus M , Ozaki, Norio , Papiol, Sergi , Pisanu, Claudia , Reif, Andreas , Reininghaus, Eva , Rouleau, Guy Armand , Rybakowski, Janusz K , Schalling, Martin , Schofield, Peter R , Schubert, Klaus Oliver , Schulte, Eva , Severino, Giovanni , Shimoda, Kazutaka , Squassina, Alessio , Streit, Fabian , Turecki, Gustavo , Vieta, E , Viswanath, Biju , Witt, Stephanie H , Alda, Martin , Bauer, M , McMahon, Francis , Mitchell, Philip B , Rietschel, Marcella , Schulze, Thomas , Cichon, Sven , Mitjans, Marina , Thalamuthu, Anbupalam , Backlund, Lena , Bellivier, Frank , Biernacka, Joanna M. , Chen, Hsi‐Chung , Colom, Francesc , Cruceanu, Cristiana , Czerski, Piotr M. , Dalkner, Nina , Degenhardt, Franziska , Étain, Bruno , Falkai, Peter , Ferensztajn‐Rochowiak, Ewa , Fullerton, Janice M. , Gallo, Carla , Goes, Fernando , Grigoroiu‐Serbânescu, Maria , Hashimoto, Ryota , Hasler, Roland , Heilbronner, Urs , Herms, Stefan , Hoffmann, Per , Jamain, Stéphane , Jiménez, Esther , Kato, Tadafumi , Kittel‐Schneider, Sarah , Kuo, Po‐Hsiu , Kurtz, Joachim , König, Barbara , Leboyer, Marion , Manchia, Mirko , Martinsson, Lina , McCarthy, Michael J. , McElroy, Susan L. , Millischer, Vincent , Monteleone, Palmiero , Novák, Tomáš , Ozaki, Norio , Papiol, Sergi , Pfennig, Andrea , Reif, Andreas , Schofield, Peter R. , Schubert, Klaus Oliver , Schulte, Eva C. , Squassina, Alessio , Stopková, Pavla , Tekola‐Ayele, Fasil , Tortorella, Alfonso , Turecki, Gustavo , Vieta, Eduard , Viswanath, Biju , Alda, Martin , McMahon, Francis J. , Baune, Bernhard
No container title available | June 26, 2023 | Volume: No volume available | Issue: No issue available | Pages: No page available
Abstract The link between bipolar disorder (BP) and immune dysfunction remains controversial. While epidemiological studies have long suggested an association, recent research has found only limited evidence of such a relationship. To clarify this, we investigated the contributions of immune-relevant genetic factors to the response to lithium (Li) treatment and the clinical presentation of BP. First, we assessed the association of a large collection of immune-related genes (4,925) with Li response, defined by the Retrospective Assessment of the Lithium Response Phenotype Scale (Alda scale), and clinical characteristics in patients with BP from the International Consortium on Lithium Genetics (ConLi+Gen, N = 2,374). Second, we calculated here previously published polygenic scores (PGSs) for immune-related traits and evaluated their associations with Li response and clinical features. We found several genes associated with Li response at p < 1x10− 4 values, including HAS3, CNTNAP5 and NFIB. Network and functional enrichment analyses uncovered an overrepresentation of pathways involved in cell adhesion and intercellular communication, which appear to converge on the well-known Li-induced inhibition of GSK-3β. We also found various genes associated with BP’s age-at-onset, number of mood episodes, and presence of psychosis, substance abuse and/or suicidal ideation at the exploratory threshold. These included RTN4, XKR4, NRXN1, NRG1/3 and GRK5. Additionally, PGS analyses suggested serum FAS, ECP, TRANCE and cytokine ligands, amongst others, might represent potential circulating biomarkers of Li response and clinical presentation. Taken together, our results support the notion of a relatively weak association between immunity and clinically relevant features of BP at the genetic level.
Solar insolation in springtime influences age of onset of bipolar I disorder
Bauer, Michael , Glenn, Tasha , Aleksandrovich, M. A., Angelopoulos, Elias, Ardau, Raffaella , Ayhan, Yavuz , Baethge, Christopher , Bharathram, S. R., Bauer, Rita, Becerra‐Palars, C., Belmaker, Robert H. , Berk, Michael , Bersudsky, Yuly, Bicakci, Ş., Bjella, Thomas , Bossini, Letizia, Cabrera, Jorge , Cheung, Eric Yat Wo, Zompo, Maria Del , Donix, Markus , Étain, Bruno , Fountoulakis, Konstantinos Ν. , Frye, Mark A. , González‐Pinto, Ana , Gottlieb, John F. , Grof, Paul , Harima, Hirohiko, Henry, Chantal , Isometsä, Erkki , Janno, Sven , Kapczinski, Flávio , Kardell, Mathias, Khaldi, S., Kliwicki, Sebastian , Kot, Timur L., Krogh, Rikke, Kunz, Maurício , Lafer, Beny , Landén, Mikael , Larsen, Erik Roj , Lewitzka, Ute , Licht, Rasmus Wentzer , López‐Jaramillo, Carlos , Manchia, Mirko , Marsh, Wendy , Melle, Ingrid , Meza-Urzúa, Fátima, Ming, Mok Yee, Monteith, Scott , Morken, Gunnar , Mosca, Enrica, Muñoz, Rodrigo , Mythri, Starlin Vijay , Nacef, F., Nery, Fabiano G. , Nielsen, René Ernst , O’Donovan, Claire , Omrani, Adel, Osher, Yamima , Sørensen, Helle Østermark , Ouali, Uta , Ruiz, Yolanda Pica, Pilhatsch, Maximilian , Pinna, Marco , Ponte, Francisco Diego Rabelo da, Quiroz, Danilo , Ramesar, Raj , Rasgon, Natalie , Reddy, M. S., Reif, Andreas , Ritter, Philipp , Sagduyu, Kemal, Scippa, Ângela Miranda, Severus, Emanuel , Simhandl, Christian , Stein, Dan J. , Strejilevich, Sergio , Sulaiman, Ahmad Hatim , Suominen, Kirsi, Tagata, Hiromi , Tatebayashi, Yoshitaka , Vaaler, A. E., Veeh, Julia, Vieta, Eduard , Viswanath, Biju , Yoldi‐Negrete, María , Zetin, Mark, Zgueb, Yosra , Whybrow, Peter C., Bauer, M , Bellivier, F , Etain, B , Vieta, E , Alda, Martin , Andreassen, Ole A. , Baune, Bernhard , Bellivier, Frank , Bicakci, Ş., Birabwa‐Oketcho, Harriet , Dodd, Seetal , Fagiolini, Andrea , König, Barbara , MacQUEEN, GLENDA M. , Martínez‐Cengotitabengoa, Mónica , MUNOZ, RODRIGO A. , Nadella, R K , Rybakowski, Janusz K , Subramaniam, M , Tondo, Leonardo , Torrent, Carla , Vaaler, A. E., Stein, Dan J , López-Jaramillo, Carlos , Fountoulakis, Konstantinos N , Reif, Andreas , Viswanath, Biju , Berk, Michael , Manchia, Mirko , Ouali, U , Ritter, P , Strejilevich, S , Yoldi-Negrete, M
Acta Psychiatrica Scandinavica | July 19, 2017 | Volume: 136 | Issue: 6 | Pages: 571-582
ObjectiveTo confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder.MethodData were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth‐cohort, family history, polarity of first episode and country physician density.ResultsThere was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth‐cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth‐cohort (all estimated coefficientsP< 0.001).ConclusionA large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LEDlighting, mobile devices backlit withLEDs) may influence adaptability to a springtime circadian challenge.