Citations 2
Clinical impact of KIR haplotypes in 10/10 HLA-matched unrelated donor-recipient pairs undergoing allogeneic hematopoietic stem cell transplantation
Moyer, Ann M. , Hashmi, Shahrukh K. , Kroning, Cynthia M., Patnaik, Mrinal M. , Litzow, Mark R. , Gastineau, Dennis A. , Hogan, William J. , Jacob, Eapen K., Kreuter, Justin D. , Wakefield, Laurie L., Patnaik, Mrinal , Litzow, Mark R. , Hogan, William J , Gandhi, Manish J.
Leukemia & Lymphoma | November 30, 2022 | Volume: 64 | Issue: 3 | Pages: 671-678
Clinical outcomes of HLA‐DPB1 mismatches in 10/10 HLA‐matched unrelated donor‐recipient pairs undergoing allogeneic stem cell transplant
Moyer, Ann M. , Hashmi, Shahrukh K. , Kroning, Cynthia M., Kremers, Walter K. , Goey, Steven R. De, Patnaik, Mrinal M. , Litzow, Mark R. , Gastineau, Dennis A. , Jacob, Eapen K., Kreuter, Justin D. , Wakefield, Laurie L., De Goey, Steven R, Hogan, William J. , Gandhi, Manish J. , Kremers, Walter K
European Journal of Haematology | June 20, 2017 | Volume: 99 | Issue: 3 | Pages: 275-282
AbstractObjectiveHLA‐DPB1 matching may impact allogeneic hematopoietic stem cell transplantation (ASCT) outcomes; however, this locus is not in linkage disequilibrium with the remainder of the HLA genes. After classifying HLA‐DPB1 mismatches based on T‐cell epitope, avoiding non‐permissive mismatches may impact survival. We tested this hypothesis at a single academic institution.MethodsRetrospective HLA‐DPB1 genotyping was performed on 153 adult patients who underwent ASCT and unrelated donors matched for HLA‐A, B, C, DRB1, and DQB1 loci (10/10). Using the ImMunoGeneTics/HLA T‐cell epitope matching algorithm, mismatch status was classified as permissive or non‐permissive.ResultsOf 153 donor‐recipient pairs, 22 (14.4%) were HLA‐DPB1 matches, 64 (42.8%) permissive mismatches, and 67 (43.8%) non‐permissive mismatches. DPB1 mismatch increased risk of chronic graft‐versus‐host disease (cGVHD; RR 2.89 [1.19‐9.53], P=.016) compared with DPB1‐matched transplants, but there were no differences in overall mortality, risk of relapse, or acute GVHD (aGVHD). Combining matches and permissive mismatches and comparing to non‐permissive mismatches, there was no significant difference in overall survival or relapse; however, patients receiving non‐permissive mismatched transplants experienced greater risk of aGVHD overall and severe aGVHD (RR 1.66 [1.13‐2.44], P=.010 and RR 1.97 [1.10‐3.59], P=.024, respectively).ConclusionIn this single‐center study, HLA‐DPB1 matching influenced outcomes of patients undergoing ASCT for hematologic malignancy.