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Bull, Todd M.

Mayo Clinic

University of Colorado Denver

Citations 14

Estrogen Metabolism in Portopulmonary Hypertension (POPH): A Case-Control Study
Krowka, Michael J. , Forde, Kimberly A. , Bull, Todd M., Bartolome, Sonja, Lin, Grace , Oh, Jae K. , Mottram, Carl, Scanlon, Paul D., Patel, M., Fallon, Michael B. , Al‐Naamani, Nadine , Heresi, Gustavo A. , Roberts, Kari E. , Hemnes, Anna R. , Krok, Karen , DuBrock, Hilary M. , Austin, Eric , Kawut, Steven M.

C52. USE YOUR ILLUSION II: CLINICAL RESEARCH IN PAH | August 26, 2019 | Volume: No volume available | Issue: No issue available | Pages: A5097-A5097

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5097 Get It

Self-Reported Pulmonary Hypertension (PH) Referral Trends Amongst U.S.-Based Physicians
Badesch, David B., Bull, Todd M., Lahm, Tim , Laughlin, A., Aune, Ragnhild E. , Brown, Laura Mae , Gray, Michael P. , DuBrock, Hilary M. , de Jesus Perez, Vinicio , Leary, Peter J. , Aune, R.

C52. USE YOUR ILLUSION II: CLINICAL RESEARCH IN PAH | August 26, 2019 | Volume: No volume available | Issue: No issue available | Pages: A5090-A5090

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5090 Get It

Increasing Age Is Associated with Worsening Physical Function Despite More Favorable Cardiopulmonary Hemodynamics: A Pulmonary Hypertension Association Registry (PHAR) Report
Kime, Noah , Bartolome, Sonja, Badesch, David B., Bull, Todd M., Chakinala, Murali M. , Elwing, Jean , Feldman, Jeremy P., Fineman, Jeffrey R. , Grinnan, D. , Mathai, S.C. , McConnell, J.W. , Presberg, Kenneth W., Robinson, Jeffrey C. , Sager, Jeffrey S., Shlobin, Oksana A. , Zamanian, Roham T. , Marco, Teresa De , Investigators, PHAR, DesJardin, Jacqueline T. , Kolaitis, Nicholas A , Kronmal, Richard A. , Benza, Raymond L. , Rosenzweig, Erika B. , Burger, Charles D. , Horn, Evelyn M. , Lammi, Matthew R. , Simon, Marc A. , Thenappan, Thenappan

A105. GLORY DAYS: THE LATEST CLINICAL RESEARCH IN PAH | August 26, 2019 | Volume: No volume available | Issue: No issue available | Pages: A2516-A2516

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2516 Get It

Enhancing Insights into Pulmonary Vascular Disease Through a Precision Medicine Approach. A Joint NHLBI–Cardiovascular Medical Research and Education Fund Workshop Report
Newman, John H. , Rich, Stuart , Alexander, John H. , Beck, Gerald J. , Benza, Raymond L. , Bull, Todd M., Chun, Hyung J. , Doogan, Declan, Dupuis, Jocelyn , Erzurum, Serpil C. , Frantz, Robert P. , Geraci, Mark W. , Gillies, Hunter , Gladwin, Mark T. , Gray, Michael P. , Hill, Nicholas S. , Hunter, Kendall S. , Jing, Zhi‐Cheng , Johns, Roger A. , Kaul, Sanjay , Lahm, Tim , Lewis, Greg , Mathai, Stephen C. , McLaughlin, Vallerie V. , Michelakis, Evangelos D. , Nathan, Steven D. , Nichols, William C. , Page, Grier P. , Rabinovitch, Marlene , Rich, Jonathan D. , Rischard, Franz , Rounds, Sharon , Shah, Sanjiv J. , Tapson, Victor F. , Lowy, Naomi, Stockbridge, Norman, Weinmann, Gail, Xiao, Lei , Xiao, Lei , Abman, Steven H. , Barnard, John , Benza, Raymond L. , Chan, Stephen Y. , Hemnes, Anna R. , Herbst, Roy S. , Hernandez, Adrian F. , Horn, Evelyn M. , Kawut, Steven M. , Leopold, Jane A. , McLaughlin, Vallerie V. , Shah, Sanjiv J , Frantz, Robert P , Rischard, Franz P , Mathai, Stephen C

American Journal of Respiratory and Critical Care Medicine | April 21, 2017 | Volume: 195 | Issue: 12 | Pages: 1661-1670

10.1164/rccm.201701-0150ws Get It

Abstract The Division of Lung Diseases of the NHLBI and the Cardiovascular Medical Education and Research Fund held a workshop to discuss how to leverage the anticipated scientific output from the recently launched “Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics” (PVDOMICS) program to develop newer approaches to pulmonary vascular disease. PVDOMICS is a collaborative, protocol-driven network to analyze all patient populations with pulmonary hypertension to define novel pulmonary vascular disease (PVD) phenotypes. Stakeholders, including basic, translational, and clinical investigators; clinicians; patient advocacy organizations; regulatory agencies; and pharmaceutical industry experts, joined to discuss the application of precision medicine to PVD clinical trials. Recommendations were generated for discussion of research priorities in line with NHLBI Strategic Vision Goals that include: (1) A national effort, involving all the stakeholders, should seek to coordinate biosamples and biodata from all funded programs to a web-based repository so that information can be shared and correlated with other research projects. Example programs sponsored by NHLBI include PVDOMICS, Pulmonary Hypertension Breakthrough Initiative, the National Biological Sample and Data Repository for PAH, and the National Precision Medicine Initiative. (2) A task force to develop a master clinical trials protocol for PVD to apply precision medicine principles to future clinical trials. Specific features include: (a) adoption of smaller clinical trials that incorporate biomarker-guided enrichment strategies, using adaptive and innovative statistical designs; and (b) development of newer endpoints that reflect well-defined and clinically meaningful changes. (3) Development of updated and systematic variables in imaging, hemodynamic, cellular, genomic, and metabolic tests that will help precisely identify individual and shared features of PVD and serve as the basis of novel phenotypes for therapeutic interventions.