Background/Purpose: To report a new technique for treating patients with uveal effusion syndrome by the fiberoptic-guided CO2 laser. Methods: Interventional case report. A 74-year-old man presented with exudative detachment of the choroid secondary to uveal effusion syndrome. Partial-thickness sclerotomy and full-thickness sclerotomy were performed to treat the disease using a fiberoptic-guided CO2 laser. Results: After the surgery, the patient's visual acuity improved and choroidal folds disappeared. Conclusion: This technique allows concomitant coagulation and cutting, thereby reducing the risk of bleeding and providing better depth control.