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Syrjanen, Jeremy A.

https://orcid.org/0000-0001-5990-8206

Mayo Clinic

for the ALLFTD consortium

Citations 112

Association of Cortical and Subcortical Aβ Deposition with Depressive and Anxiety Symptoms: A Population-based Cross-sectional Study (P5.1-028)
Vassilaki, Maria , Syrjanen, Jeremy A. , Curnutt, Nicole, Gritsch, David , Lowe, Val J. , Petersen, Ronald C. , Krell‐Roesch, Janina , Vemuri, Prashanthi , Mielke, Michelle M. , Jack, Clifford R. , Kremers, Walter K. , Knopman, David S. , Stokin, Gorazd B. , Geda, Yonas E.

Neurology | December 7, 2023 | Volume: 92 | Issue: 15_supplement | Pages: No page available

10.1212/wnl.92.15_supplement.p5.1-028 Get It

The Multidomain Impairment Rating (MIR) Scale: Initial Reliability Data on a Multidimensional Scale for FTLD (P5.1-010)
Rosen, Howard J. , Boxer, Adam L. , Kornak, John , Heuer, Hilary W. , Fields, Julie A. , Forsberg, Leah K. , Brushaber, Danielle , Sturm, Virginia E. , Ljubenkov, Peter A. , Dever, Reilly, Syrjanen, Jeremy A. , Boeve, Bradley F. , Machulda, Mary M. , Kremers, Walter K.

Neurology | December 7, 2023 | Volume: 92 | Issue: 15_supplement | Pages: No page available

10.1212/wnl.92.15_supplement.p5.1-010 Get It

Motor Features In Familial Frontotemporal Dementia due to MAPT, GRN or C9orf72 mutations (P3.1-007)
Deutschländer, Angela , Savica, Rodolfo , Brushaber, Danielle , Syrjanen, Jeremy A. , Rosen, Howard J. , Boxer, Adam L. , Heckman, Michael G. , Boeve, Bradley F. , Wszołek, Zbigniew K.

Neurology | December 7, 2023 | Volume: 92 | Issue: 15_supplement | Pages: No page available

10.1212/wnl.92.15_supplement.p3.1-007 Get It

Utility of the FTLD-CDR in the mild FTLD: Data from the ARTFL/LEFFTDS Consortium (P3.1-001)
Miyagawa, Toji , Brushaber, Danielle , Dever, Reilly, Fields, Julie A. , Forsberg, Leah K. , Gavrilova, Ralitza H. , Heuer, Hilary W. , Kornak, John , Kramer, Joel H. , Rascovsky, Katya, Syrjanen, Jeremy A. , Boxer, Adam L. , Rosen, Howard J. , Knopman, David S. , Kremers, Walter K. , Rankin, Kelsey A. , Boeve, Bradley F.

Neurology | December 7, 2023 | Volume: 92 | Issue: 15_supplement | Pages: No page available

10.1212/wnl.92.15_supplement.p3.1-001 Get It

Mediterranean Diet and MRI Biomarkers of Cortical Thickness in Cognitively Normal Persons (P1.093)
Roberts, Rosebud O., Staubo, Sara C., Aakre, Jeremiah A. , Syrjanen, Jeremy A. , Vassilaki, Maria , Petersen, Ronald, Kremers, Walter K. , Vemuri, Prashanthi , Mielke, Michelle M. , Machulda, Mary M. , Geda, Yonas E. , Knopman, David S. , Jack, Clifford R.

Neurology | December 7, 2023 | Volume: 86 | Issue: 16_supplement | Pages: No page available

10.1212/wnl.86.16_supplement.p1.093 Get It

Characteristics and Progress on the Initial 209 Subjects in the Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS) Protocol (P2.088)
Rosen, Howard J. , Boxer, Adam L. , Coppola, Giovanni , Dheel, Christina, Dickerson, Bradford, Faber, Kelley, Fields, Julie A. , Gavrilova, Ralitza H. , Ghoshal, Nupur , Graff‐Radford, Neill R. , Heuer, Hilary W. , Huey, Edward D. , Karydas, Anna, Kornak, John , Mackenzie, Ian R. , Miller, Matt, Phelps, Creighton H., Rademakers, Rosa , Rankin, Katherine , Shaw, Leslie M. , Sutherland, Margaret , Syrjanen, Jeremy A. , Toga, Arthur W. , Trojanowski, John Q. , Vetor, Ashley, Weıntraub, Sandra , Boeve, Bradley F. , Foroud, Tatiana , Goldman, Jill , Grossman, Murray , Hsiao, John , Hsiung, Ging‐Yuek Robin , Irwin, David J. , Kantarci, Kejal , Knopman, David S. , Kukull, Walter A. , Miller, Bruce L. , Wszołek, Zbigniew K.

Neurology | December 7, 2023 | Volume: 88 | Issue: 16_supplement | Pages: No page available

10.1212/wnl.88.16_supplement.p2.088 Get It

The ARTFL LEFFTDS Frontotemporal Lobar Degeneration (ALLFTD) Protocol: Preliminary Data and Future Plans (2081)
Boxer, Adam L. , Rosen, Howard, Forsberg, Leah K. , Heuer, Hilary W. , Brushaber, Danielle , Bordelon, Yvette , Dickerson, Bradford, Dickinson, Susan, Faber, Kelley , Fagan, Anne M. , Fields, Julie A. , Fishman, Ann, Gavrilova, Ralitza H. , Gendron, Tania, Geschwind, Daniel H. , Ghoshal, Nupur , Graff‐Radford, Jonathan , Graff‐Radford, Neill R. , Grant, Ian , Huey, Edward D. , Karydas, Anna, Kaufer, Daniel , Kramer, Joel H. , Kornak, John , Lagone, Emma, Ljubenkov, Peter A. , Lucente, Diane , Mackenzie, Ian R. , Manoochehri, Masood , Masdeu, Joseph C. , McGinnis, Scott, Mendez, Mario F. , Miller, Bruce, Miyagawa, Toji , Nelson, K. , Onyike, Chiadi U. , Pearlman, Rodney , Petrucelli, Leonard , Rademakers, Rosa , Ramos, Eliana Marisa , Rankin, Katherine P. , Rascovsky, Katya, Ritter, Aaron, -Martinez, Julio Rojas, Sabbagh, Marwan N. , Salmon, David P. , Savica, Rodolfo , Staffaroni, Adam M. , Syrjanen, Jeremy A. , Tatton, Nadine , Taylor, Joanne, Toga, Arthur W. , Weıntraub, Sandra , Wheaton, Diana, Boeve, Bradley F. , Appleby, Brian S. , Biernacka, Joanna M. , Botha, Hugo , Brannelly, Patrick , Dickson, Dennis W. , Domoto‐Reilly, Kimiko , Foroud, Tatiana , Galasko, Douglas , Gendron, Tania F. , Goldman, Jill , Grossman, Murray , Hsiung, Ging‐Yuek Robin , Huang, Eric J. , Irwin, David J. , Jones, David T. , Kantarci, Kejal , Knopman, David S. , Kremers, Walter K. , Kukull, Walter A. , Litvan, Irene , Masdeu, Joseph C , Nelson, Kevin, Pantelyat, Alexander , Pascual, Belén , Rexach, Jessica E. , Roberson, Erik D. , Seeley, William W. , Tartaglia, Maria Carmela , Wong, Bonnie , Wszołek, Zbigniew K.

Neurology | December 7, 2023 | Volume: 94 | Issue: 15_supplement | Pages: No page available

10.1212/wnl.94.15_supplement.2081 Get It

Association of Cerebrovascular Imaging Biomarkers, Depression, and Anxiety, with Mild Cognitive Impairment
Vassilaki, Maria , Syrjanen, Jeremy A. , Krell‐Roesch, Janina , Graff‐Radford, Jonathan , Vemuri, Prashanthi , Fields, Julie A. , Kremers, Walter K. , Lowe, Val J. , Petersen, Ronald C. , Geda, Yonas E. , Vemuri, Prashanthi , Geda, Yonas E , Kremers, Walter K , Scharf, Eugene , Machulda, Mary M. , Jack, Clifford R. , Knopman, David S.

Journal of Alzheimer's Disease Reports | November 3, 2023 | Volume: 7 | Issue: 1 | Pages: 1237-1246

10.3233/adr-230073 Get It

The study included 1,738 Mayo Clinic Study of Aging participants (≥50 years old; 1,460 cognitively unimpaired and 278 with mild cognitive impairment (MCI)) and examined the cross-sectional association between cerebrovascular (CVD) imaging biomarkers (e.g., white matter hyperintensities (WMH), infarctions) and Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI) scores, as well as their association with MCI. High (abnormal) WMH burden was significantly associated with having BDI-II>13 and BAI > 7 scores, and both (CVD imaging biomarkers and depression/anxiety) were significantly associated with MCI when included simultaneously in the model, suggesting that both were independently associated with the odds of MCI.
Association of Plasma Biomarkers of Alzheimer Disease With Cognition and Medical Comorbidities in a Biracial Cohort
Ramanan, Vijay K. , Graff‐Radford, Jonathan , Syrjanen, Jeremy A. , Shir, Dror , Lucas, John A. , Martens, Yuka A. , Carrasquillo, Minerva M. , Day, Gregory S. , Ertekin‐Taner, Nilüfer , Lachner, Christian , Willis, Floyd B. , Jack, Clifford R. , Petersen, Ronald C. , Vemuri, Prashanthi , Graff‐Radford, Neill R. , Lucas, John, Atagi, Yuka , Day, Gregory S , Jack, Clifford R , Petersen, Ronald C , Mielke, Michelle M , Vemuri, Prashanthi , Ramanan, Vijay K , Shir, Dror , Algeciras‐Schimnich, Alicia , Carrasquillo, Minerva M. , Knopman, David S. , Mielke, Michelle M.

Neurology | August 14, 2023 | Volume: 101 | Issue: 14 | Pages: No page available

10.1212/wnl.0000000000207675 Get It

Plasma‐derived biomarkers of Alzheimer's disease and neuropsychiatric symptoms: A community‐based study
Krell‐Roesch, Janina , Syrjanen, Jeremy A. , Kremers, Walter K. , Dage, Jeffrey L. , Fields, Julie A. , Petersen, Ronald C. , Vassilaki, Maria , Geda, Yonas E. , Zaniletti, Isabella, Geda, Yonas E , Kremers, Walter K , Dage, Jeffrey L , Zaniletti, Isabella , Algeciras‐Schimnich, Alicia , Harten, Argonde C. van , Knopman, David S. , Jack, Clifford R.

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring | July 31, 2023 | Volume: 15 | Issue: 3 | Pages: No page available

10.1002/dad2.12461 Get It

AbstractINTRODUCTIONWe examined associations between plasma‐derived biomarkers of Alzheimer's disease (AD) and neuropsychiatric symptoms (NPS) in community‐dwelling older adults.METHODSCross‐sectional study involving 1005 persons ≥50 years of age (mean 74 years, 564 male, 118 cognitively impaired), who completed plasma‐derived biomarker (amyloid beta 42 [Aβ42]/Aβ40, phosphorylated tau 181 [p‐tau181], p‐tau217, total tau [t‐tau], neurofilament light [NfL]), and NPS assessment.RESULTSP‐tau181 (odds ratio [OR] 2.06, 95% confidence interval [CI] 1.41–3.00, p < 0.001), p‐tau217 (OR 1.70, 95% CI 1.10–2.61, p = 0.016), and t‐tau (OR 1.44, 95% CI 1.08–1.92, p = 0.012) were associated with appetite change. We also found that p‐tau181 and p‐tau217 were associated with increased symptoms of agitation (OR 1.93, 95% CI 1.20–3.11, p = 0.007 and OR 2.04, 95% CI 1.21–3.42, p = 0.007, respectively), and disinhibition (OR 2.39, 95% CI 1.45–3.93, p = 0.001 and OR 2.30, 95% CI 1.33–3.98, p = 0.003, respectively). Aβ42/Aβ40 and NfL were not associated with NPS.CONCLUSIONHigher plasma‐derived p‐tau181 and p‐tau217 levels are associated with increased symptoms of appetite change, agitation, and disinhibition. These findings may support the validity of plasma tau biomarkers for predicting behavioral symptoms that often accompany cognitive impairment.HIGHLIGHTS We studied 1005 community‐dwelling persons aged ≥ 50 years Higher plasma tau levels are associated with increased neuropsychiatric symptoms Aβ42/Aβ40 and NfL are not associated with neuropsychiatric symptoms Clinicians should treat neuropsychiatric symptoms in persons with high plasma‐derived tau