Citations 70
F5‐05‐03: Detecting Functional Impairment in Preclinical Alzheimer’s Disease using a Brief Performance Measure of Financial Skills
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Alzheimer's & Dementia | October 17, 2016 | Volume: 12 | Issue: 7S_Part_7 | Pages: No page available
Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults
Risacher, Shannon L. , McDonald, Brenna C. , Tallman, Eileen F., West, John D. , Farlow, Martin R. , Unverzagt, Fredrick, Gao, Sujuan , Boustani, Malaz, Crane, Paul K. , Petersen, Ronald , Jack, Clifford R. , Jagust, William, Aisen, Paul , Weiner, Michael W. , Saykin, Andrew J. , Initiative, for the Alzheimer’s Disease Neuroimaging, Morris, John C. , Kantarci, Kejal , Senjem, Matthew L. , Porsteinsson, Anton P. , Feldman, Howard , Snyder, Peter J. , Vemuri, Prashanthi , Mathis, Chester A. , Shah, Raj C. , Burns, Jeffrey M. , Obisesan, Thomas O. , Preda, Adrian , Finger, Elizabeth , Crane, Paul K. , Jicha, Gregory A. , Bartha, Robert , Womack, Kyle , Silbert, Lisa C. , Ponto, Laura L. Boles , Maillard, Pauline , Hsiao, John , Brosch, Jared R. , Arfanakis, Konstantinos , Initiative, for the Alzheimer’s Disease Neuroimaging, Finger, Elizabeth C. , Jack, Clifford R , Vemuri, Prashanthi , Saykin, Andrew J , Preda, Adrian , Senjem, Matthew L , Kantarci, Kejal , Morris, John C , Shah, Raj C , Feldman, Howard H , Jicha, Gregory A , Maillard, Pauline , Quiceno, Mary
JAMA Neurology | April 18, 2016 | Volume: 73 | Issue: 6 | Pages: 721
IC‐P‐034: Anticholinergic medication use in older adults is associated with memory and hippocampal volume
Kim, Sungeun , Aisen, Paul, Petersen, Ronald , Weiner, Michael W. , (ADNI), Alzheimer's Disease Neuroimaging Initiative, Risacher, Shannon L. , Nho, Kwangsik T. , Shen, Li , Crane, Paul K. , Jack, Clifford R. , Saykin, Andrew J. , (ADNI), Alzheimer's Disease Neuroimaging Initiative
Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_1 | Pages: No page available
P3‐014: Influence of rare RELN variants on quantitative PET imaging and CSF phenotypes in late‐onset Alzheimer's disease
Aisen, Paul, Petersen, Ronald , Jagust, William J. , Shaw, Leslie M. , Trojanowski, John Q., Weiner, Michael W. , Greicius, Michael D. , Nho, Kwangsik T. , Kim, Sungeun , Risacher, Shannon L. , Foroud, Tatiana , Jack, Clifford R. , Trojanowski, John Q., Green, Robert C. , Toga, Arthur W. , Saykin, Andrew J.
Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_13 | Pages: No page available
P1‐193: Anticholinergic medication use in older adults is associated with memory and hippocampal volume
Kim, Sungeun , Aisen, Paul, Petersen, Ronald , Weiner, Michael W. , (ADNI), the Alzheimer's Disease Neuroimaging Initiative, Risacher, Shannon L. , Nho, Kwangsik T. , Shen, Li , Crane, Paul K. , Jack, Clifford R. , Saykin, Andrew J. , (ADNI), the Alzheimer's Disease Neuroimaging Initiative
Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_9 | Pages: No page available
IC‐P‐042: Influence of rare reelin variants on quantitative PET imaging and CSF phenotypes in late‐onset Alzheimer's disease
Aisen, Paul, Petersen, Ronald , Jagust, William J. , Shaw, Leslie M. , Trojanowski, John Q., Weiner, Michael W. , Greicius, Michael D. , Nho, Kwangsik T. , Kim, Sungeun , Risacher, Shannon L. , Foroud, Tatiana , Jack, Clifford R. , Trojanowski, John Q., Green, Robert C. , Toga, Arthur W. , Saykin, Andrew J.
Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_1 | Pages: No page available
P1‐319: Alzheimer's prevention registry: A shared resource to the scientific community to facilitate enrollment in studies
High, Nellie, Reiman, Eric M. , Aisen, Paul, Albert, Marilyn S. , Comer, Meryl, Petersen, Ronald , Strobel, Gabrielle, Weiner, Michael W. , Tariot, Pierre N. , Langbaum, Jessica B. S. , Cummings, Jeffrey L. , Manly, Jennifer J. , Sperling, Reisa Anne
Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_10 | Pages: No page available
P2‐079: Neuronal origin plasma exosomes provide novel biomarkers for lysosomal dysfunction in Alzheimer's disease
Kapogiannis, Dimitrios , Eitan, Erez , Boxer, Adam L. , Petersen, Ronald , Goetzl, Edward J. , Mustapić, Maja , Schwartz, Janice B. , Abner, Erin L. , Miller, Bruce L.
Alzheimer's & Dementia | December 15, 2015 | Volume: 11 | Issue: 7S_Part_11 | Pages: No page available
Brain amyloidosis ascertainment from cognitive, imaging, and peripheral blood protein measures
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Neurology | January 22, 2015 | Volume: 84 | Issue: 7 | Pages: 729-737
Protective variant for hippocampal atrophy identified by whole exome sequencing
Kim, Sungeun , Risacher, Shannon L. , Shen, Li , Corneveaux, Jason J., Swaminathan, Shanker , Lin, Hai , Inlow, Mark , Siniard, Ashley L., Reiman, Rebecca, Aisen, Paul, Petersen, Ronald , Jack, Clifford R. , Weiner, Michael W. , Baldwin, Clinton T., Lunetta, Kathryn L. , Farrer, Lindsay A. , Furney, Simon J. , Lovestone, Simon , Simmons, Andrew , Mecocci, Patrizia , Vellas, Bruno , Tsolaki, Magda , Kłoszewska, Iwona, McDonald, Brenna C. , Farlow, Martin R. , Study, for the Indiana Memory and Aging, Huentelman, Matthew J. , Saykin, Andrew J. , Initiative, for the Alzheimer's Disease Neuroimaging, Nho, Kwangsik T. , Ramanan, Vijay K. , Liu, Yunlong , Foroud, Tatiana , Green, Robert C. , Soininen, Hilkka S. , Ghetti, Bernardino , Study, for the Indiana Memory and Aging, Initiative, for the Alzheimer's Disease Neuroimaging, Jack, Clifford R , Saykin, Andrew J , Shen, Li , Tsolaki, Magda , Mecocci, Patrizia
Annals of Neurology | January 5, 2015 | Volume: 77 | Issue: 3 | Pages: 547-552
We used whole‐exome sequencing to identify variants other than APOE associated with the rate of hippocampal atrophy in amnestic mild cognitive impairment. An in‐silico predicted missense variant in REST (rs3796529) was found exclusively in subjects with slow hippocampal volume loss and validated using unbiased whole‐brain analysis and meta‐analysis across 5 independent cohorts. REST is a master regulator of neurogenesis and neuronal differentiation that has not been previously implicated in Alzheimer's disease. These findings nominate REST and its functional pathways as protective and illustrate the potential of combining next‐generation sequencing with neuroimaging to discover novel disease mechanisms and potential therapeutic targets. Ann Neurol 2015;77:547–552