Citations 1
Secretion of Proinflammatory Cytokines and Chemokines during Amphotericin B Exposure Is Mediated by Coactivation of Toll-Like Receptors 1 and 2
Hénault, Martin, Laethem, Carmen, Johnston, Paul A. , Watson, H L, Payá, Carlos V., Razonable, Raymund R. , Lee, Linda N.
Antimicrobial Agents and Chemotherapy | March 25, 2005 | Volume: 49 | Issue: 4 | Pages: 1617-1621
10.1128/aac.49.4.1617-1621.2005
ABSTRACT Amphotericin B (AmB) is a ligand of toll-like receptor 2 (TLR2). Here, we demonstrate the participation of TLR1 in AmB-induced cell activation that led to the secretion of tumor necrosis factor alpha, interleukin 6 (IL-6), and IL-8. Hence, TLR2-TLR1 coactivation serves as the underlying mechanism for the proinflammatory toxicities associated with AmB.