Mayo Clinic - AuthorCitation

Toll-Like Receptors: Novel Molecular Targets for Antiviral Immunotherapy

Eid, Albert, Hénault, Martin, Razonable, Raymund R.

Antiviral Research | April 30, 2014 | Volume: No volume available | Issue: No issue available | Pages: 333-346

Nystatin Induces Secretion of Interleukin (IL)-1β, IL-8, and Tumor Necrosis Factor Alpha by a Toll-Like Receptor-Dependent Mechanism

Hénault, Martin, Watson, H L, Payá, Carlos V., Razonable, Raymund R.

Antimicrobial Agents and Chemotherapy | July 27, 2005 | Volume: 49 | Issue: 8 | Pages: 3546-3549

10.1128/aac.49.8.3546-3549.2005

ABSTRACT Nystatin is an antifungal compound with potent proinflammatory properties. Herein, we demonstrate that nystatin induces interleukin (IL)-1β, IL-8, and tumor necrosis factor alpha secretion through its activation of toll-like receptor 1 (TLR1) and TLR2. Hence, a TLR-dependent mechanism could serve as the molecular basis for the proinflammatory properties of nystatin.

Secretion of Proinflammatory Cytokines and Chemokines during Amphotericin B Exposure Is Mediated by Coactivation of Toll-Like Receptors 1 and 2

Hénault, Martin, Laethem, Carmen, Johnston, Paul A. , Watson, H L, Payá, Carlos V., Razonable, Raymund R. , Lee, Linda N.

Antimicrobial Agents and Chemotherapy | March 25, 2005 | Volume: 49 | Issue: 4 | Pages: 1617-1621

10.1128/aac.49.4.1617-1621.2005

ABSTRACT Amphotericin B (AmB) is a ligand of toll-like receptor 2 (TLR2). Here, we demonstrate the participation of TLR1 in AmB-induced cell activation that led to the secretion of tumor necrosis factor alpha, interleukin 6 (IL-6), and IL-8. Hence, TLR2-TLR1 coactivation serves as the underlying mechanism for the proinflammatory toxicities associated with AmB.