Citations 2
Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop
McKee, Ann C. , Snyder, Heather M. , Greenberg, Steven M. , Yaffe, Kristine , Schaffer, Chris B. , Yuan, Chun , Hughes, Timothy M. , Williamson, Jeff D. , González, Héctor M. , Wellington, Cheryl L. , Katušić, Zvonimir S. , Stoeckel, Luke E. , Corriveau, Roderick A. , Fine, Lawrence J., Galis, Zorina S. , Reis, Jared P. , Wright, Jacqueline D. , Chen, Jue , Galis, Zorina S , Gonzalez, Hector M , Zloković, Berislav V. , Gottesman, Rebecca F. , Bernstein, Kenneth E. , Seshadri, Sudha , Daemen, Mat J.A.P. , Schneider, Julie A. , Koenig, James I. , Chen, Jue
Alzheimer's & Dementia | October 8, 2020 | Volume: 16 | Issue: 12 | Pages: 1714-1733
Abstract Vascular contributions to cognitive impairment and dementia (VCID) are characterized by the aging neurovascular unit being confronted with and failing to cope with biological insults due to systemic and cerebral vascular disease, proteinopathy including Alzheimer's biology, metabolic disease, or immune response, resulting in cognitive decline. This report summarizes the discussion and recommendations from a working group convened by the National Heart, Lung, and Blood Institute and the National Institute of Neurological Disorders and Stroke to evaluate the state of the field in VCID research, identify research priorities, and foster collaborations. As discussed in this report, advances in understanding the biological mechanisms of VCID across the wide spectrum of pathologies, chronic systemic comorbidities, and other risk factors may lead to potential prevention and new treatment strategies to decrease the burden of dementia. Better understanding of the social determinants of health that affect risks for both vascular disease and VCID could provide insight into strategies to reduce racial and ethnic disparities in VCID.
Vascular contributions to cognitive impairment and dementia including Alzheimer's disease
Snyder, Heather M. , Corriveau, Roderick A. , Craft, Suzanne , Faber, James E. , Greenberg, Steven M. , Lamb, Bruce T. , Montine, Thomas J. , Schaffer, Chris B. , Wellington, Cheryl L. , Zipfel, Gregory J. , Bain, Lisa J. , Bosetti, Francesca , Galis, Zorina S. , Carrillo, María C. , Knopman, David S. , Nedergaard, Maiken , Schneider, Julie A. , Wilcock, Donna M. , Zloković, Berislav V. , Koroshetz, Walter J. , Galis, Zorina S
Alzheimer's & Dementia | December 12, 2014 | Volume: 11 | Issue: 6 | Pages: 710-717
Abstract Scientific evidence continues to demonstrate the linkage of vascular contributions to cognitive impairment and dementia such as Alzheimer's disease. In December, 2013, the Alzheimer's Association, with scientific input from the National Institute of Neurological Disorders and Stroke and the National Heart, Lung and Blood Institute from the National Institutes of Health, convened scientific experts to discuss the research gaps in our understanding of how vascular factors contribute to Alzheimer's disease and related dementia. This manuscript summarizes the meeting and the resultant discussion, including an outline of next steps needed to move this area of research forward.