Citations 1
Validation of ZAP-70 methylation and its relative significance in predicting outcome in chronic lymphocytic leukemia
Claus, Rainer , Lucas, David , Ruppert, Amy S. , Williams, Katie , Weng, Daniel , Patterson, Kara, Zucknick, Manuela , Oakes, Christopher C. , Rassenti, Laura Z., Greaves, Andrew, Geyer, Susan M. , Brown, Jennifer R. , Barrientos, Jacqueline C. , Rai, Kanti R., Shields, Peter G. , Zhao, Weiqiang , Grever, Michael R. , Plass, Christoph , Byrd, John C. , Byrd, John C. , Wierda, William G. , Gribben, John G. , Rai, Kanti R., Kay, Neil E. , Kipps, Thomas J. , Barrientos, Jacqueline , Byrd, John C
Blood | May 28, 2014 | Volume: 124 | Issue: 1 | Pages: 42-48
Key Points Methylation analysis at ZAP-70 CpG+223 in CLL provides superior prognostic information vs IGHV status or CD38 or ZAP-70 expression. A pyrosequencing method for the feasible assessment of CpG+223 methylation in CLL samples is provided.