Arshad, Faraz

Abstract Disclosure: M. Kakakhel: None. M. Hussein: None. S. Fatima: None. F. Arshad: None. D. Rizwan: None. A. Qadeer: None. M. Khawar: None. R. Haider: None. S. Batool: None. H. Jawad: None. N.U. saleem: None. H. Ahmad: None. F. Ahmed: None. R. Kirchoff: None. R. Kirchoff: None. Background: With a global prevalence of 586,000 cases of thyroid cancer, thyroid cancer is the 10th most common malignancy. Despite advancements in early detection and treatment, the incidence of thyroid cancer continues to increase in the United States. This study aims to assess disparities in mortality trends stratified by age, sex, race, geography, urbanization status, and location of death, to guide clinical decision making. Methodology: Mortality data on thyroid cancer were extracted from the CDC-WONDER database, from 1999 to 2020. Age-adjusted mortality rates (AAMRs) and crude mortality rates (CMRs) per 100,000 were stratified by age, sex, race, geography, urbanization status, and place of death. Joinpoint regression software was used to determine annual percent change (APC) and average APC. Results: From 1999 to 2020, a total of 46,777 deaths attributed to thyroid cancer occurred in the United States, among individuals aged ≥ 25 years. The overall AAMRs showed a positive trend, increasing from 0.6 per 100,000 (95% CI: 0.5-0.6) in 1999, to 0.7 (95% CI: 0.7 - 0.7) in 2020. 56.63% of those deaths, or 26,493 deaths, occurred in women. When stratified by age group, the 85+ age group had the highest CMR of 9 (95% CI: 8.3-9.7). The racial group with the highest AAMRs were Whites, with an AAMR of 0.7 per 100,000. Mortalities in the South region accounted for 33.5% of total deaths. Moreover, metro areas also had higher mortality rates than non-metro areas. Information regarding place of death was only available for 8242 deaths, with 2763 of them occurring in medical settings. Conclusion: Mortality rates in all population groups increased from 1999 to 2020, with variations in mortality rates noted among them. Risk stratification of high-risk groups, such as older people and women, and targeted interventions are key for addressing disparities in mortality rates. Presentation: Saturday, July 12, 2025

Abstract Disclosure: M. Kakakhel: None. S. Cheema: None. R. Haider: None. M. Filal: None. A. Ullah: None. M.U. Hussain: None. M.A. Sadiq: None. T. Asghar: None. F. Arshad: None. N.K. Binashikhbubkr: None. H. Jawad: None. A. Abdullah: None. M. Qadri: None. A. Qadeer: None. M. Khawar: None. H. Ahmad: None. F. Ahmed: None. R. Alcaraz: None. Background: Hypertension is a major global health issue, affecting nearly half of U.S. adults. It is a leading risk factor for cardiovascular diseases like stroke, heart attack, and heart failure. Additionally, it is often linked to endocrine disorders, which can result in secondary hypertension. Endocrine disorders contributed to a concerning 2,383,332 deaths in the United States between 1999 and 2020, with many of these individuals having underlying hypertension. Methods: Death certificate data for adults aged 25 and older were obtained from the CDC-WONDER database. Crude mortality rates (CMR) and age-adjusted mortality rates (AAMRs) per 100,000 individuals were computed. Temporal trends were analyzed by calculating the annual percent change (APC) and the average annual percent change (AAPC) in the rates using Joinpoint regression analysis. Results: The age-adjusted mortality rate (AAMR) rose sharply from 10.7 (95% CI:10.6-10.9) in 1999 to 24.9 (95% CI: 9.5 to 56.7) in 2001, then continued to increase steadily to 36.5 (95% CI: 0.6 to 2.1) by 2018. From 2018 onwards, the rate spiked significantly, reaching 51.7 (95% CI: 9.3 to 23.5) in 2020, which coincided with the COVID-19 pandemic. Men had higher overall AAMR i.e. 36.6 as compared to women 28.4 during the span of this study. Stratifying by race, Non-Hispanic Blacks or African Americans had the highest overall age-adjusted mortality rate at 64.4 vs non-Hispanic whites, who had the lowest rate at 27.6. Southern states exhibited the highest mortality rates among the census region followed by the Western, Midwestern, and Northeastern regions. In contrast, the Annual Mortality Rates (AAMRs) displayed similar patterns across all regions. Regarding age, people aged 85 and above had the highest mortality rate among all the age groups while ages 25-34 had the lowest. Conclusion: Endocrine disorders associated with underlying hypertension showed an increasing trend throughout the study period, peaking during the COVID-19 pandemic. These findings account for immediate targeted interventions directed at the most vulnerable demographic and geographical groups Presentation: Monday, July 14, 2025