Jacob, Saiju
Mayo Clinic
University Hospitals Birmingham NHS Foundation Trust
Citations 1
Fatigue predicts quality of life after leucine‐rich glioma‐inactivated 1‐antibody encephalitis
Binks, Sophie , Maddison, Paul , Coebergh, Jan, Michael, Sophia , Easton, Ava , Nissen, Mette Scheller , Leite, Maria Isabel , Irani, Sarosh R. , Blaabjerg, Morten , Irani, Sarosh R , Binks, Sophie N M , Veldsman, Michele , Handel, Adam E. , Jacob, Saiju , Coebergh, Jan , Ramanathan, Sudarshini , Okai, David , Husain, Masud
Annals of Clinical and Translational Neurology | February 2, 2024 | Volume: 11 | Issue: 4 | Pages: 1053-1058
Abstract Patient‐reported quality‐of‐life (QoL) and carer impacts are not reported after leucine‐rich glioma‐inactivated 1‐antibody encephalitis (LGI1‐Ab‐E). From 60 patients, 85% (51 out of 60) showed one abnormal score across QoL assessments and 11 multimodal validated questionnaires. Compared to the premorbid state, QoL significantly deteriorated ( p < 0.001) and, at a median of 41 months, fatigue was its most important predictor ( p = 0.025). In total, 51% (26 out of 51) of carers reported significant burden. An abbreviated five‐item battery explained most variance in QoL. Wide‐ranging impacts post‐LGI1‐Ab‐E include decreased QoL and high caregiver strain. We identify a rapid method to capture QoL in routine clinic or clinical trial settings.