Citations 1
Relationship of circulating levels of long-chain fatty acids to persistent organ failure in acute pancreatitis
Phillips, Anna Evans , Hinton, Alice , Pothoulakis, Ioannis , Lee, Peter J. , Lahooti, Ila , Whitcomb, David C. , Singh, Vijay , Whitcomb, David C , Wilson, Annette Scierka , Greer, Phil J. , Culp, Stacey , Paragomi, Pedram , Papachristou, Georgios I.
American Journal of Physiology-Gastrointestinal and Liver Physiology | July 18, 2023 | Volume: 325 | Issue: 3 | Pages: G279-G285
Drivers of the inflammatory response in acute pancreatitis remain incompletely understood. Unsaturated fatty acids, specifically palmitoleic, appear to have an association with more severe acute pancreatitis. This finding presents a new clinical understanding of fatty acid toxicity and highlights a potential future target for treatment in severe acute pancreatitis.