Back to Authors

Yan, Qun

0000-0001-7347-618X

Mayo Clinic

Central South University

Citations 4

Exebacase in Addition to Daptomycin Is More Active than Daptomycin or Exebacase Alone in Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats
Karau, Melissa J. , Schmidt-Malan, Suzannah M., Greenwood‐Quaintance, Kerryl E. , Mandrekar, Jayawant N. , Lehoux, Dario , Schuch, Raymond , Cassino, Cara, Patel, Robin , Mandrekar, Jayawant, Schuch, Raymond , Patel, Robin , Yan, Qun

Antimicrobial Agents and Chemotherapy | July 30, 2019 | Volume: 63 | Issue: 10 | Pages: No page available

10.1128/aac.01235-19 Get It

Bacteriophage-derived lysins are being developed as anti-infective agents. In an acute osteomyelitis methicillin-resistant Staphylococcus aureus (MRSA) model, rats receiving no treatment or treatment with daptomycin, exebacase (CF-301), or daptomycin plus exebacase had means of 5.13, 4.09, 4.65, and 3.57 log 10 CFU/gram of bone, respectively.
Evaluation of the CosmosID Bioinformatics Platform for Prosthetic Joint-Associated Sonicate Fluid Shotgun Metagenomic Data Analysis
Wi, Yu Mi , Thoendel, Matthew , Raval, Yash S. , Greenwood‐Quaintance, Kerryl E. , Jeraldo, Patricio , Patel, Robin , Yan, Qun , Thoendel, Matthew J, Jeraldo, Patricio R , Chia, Nicholas , Patel, Robin , Yan, Qun , Abdel, Matthew P. , Chia, Nicholas , Thoendel, Matthew J , Raval, Yash S.

Journal of Clinical Microbiology | November 9, 2018 | Volume: 57 | Issue: 2 | Pages: No page available

10.1128/jcm.01182-18 Get It

We previously demonstrated that shotgun metagenomic sequencing can detect bacteria in sonicate fluid, providing a diagnosis of prosthetic joint infection (PJI). A limitation of the approach that we used is that data analysis was time-consuming and specialized bioinformatics expertise was required, both of which are barriers to routine clinical use.
Evaluation of Oritavancin Combinations with Rifampin, Gentamicin, or Linezolid against Prosthetic Joint Infection-Associated Methicillin-Resistant Staphylococcus aureus Biofilms by Time-Kill Assays
Karau, Melissa J. , Raval, Yash S. , Patel, Robin , Yan, Qun , Patel, Robin , Yan, Qun , Raval, Yash S.

Antimicrobial Agents and Chemotherapy | July 13, 2018 | Volume: 62 | Issue: 10 | Pages: No page available

10.1128/aac.00943-18 Get It

The antibiofilm activity of oritavancin in combination with rifampin, gentamicin, or linezolid was evaluated against 10 prosthetic joint infection (PJI)-related methicillin-resistant Staphylococcus aureus (MRSA) isolates by time-kill assays. Oritavancin combined with rifampin demonstrated statistically significant bacterial reductions compared with those of either antimicrobial alone for all 10 isolates ( P ≤ 0.001), with synergy being observed for 80% of the isolates.
Evaluation of Non-Tissue Culture- versus Tissue Culture-Treated Microplates for Oritavancin Susceptibility Testing
Karau, Melissa J. , Patel, Robin , Yan, Qun , Patel, Robin , Yan, Qun

Journal of Clinical Microbiology | January 24, 2018 | Volume: 56 | Issue: 4 | Pages: No page available

10.1128/jcm.02001-17 Get It