Citations 2
Activity of Lysin CF-296 Alone and in Addition to Daptomycin in a Rat Model of Experimental Methicillin-Resistant Staphylococcus aureus Osteomyelitis
Karau, Melissa J. , Schmidt-Malan, Suzannah M., Mandrekar, Jay , Lehoux, Dario , Schuch, Raymond , Cassino, Cara, Patel, Robin , Patel, Robin , Schuch, Raymond
Antimicrobial Agents and Chemotherapy | March 16, 2021 | Volume: 65 | Issue: 6 | Pages: No page available
Exebacase in Addition to Daptomycin Is More Active than Daptomycin or Exebacase Alone in Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats
Karau, Melissa J. , Schmidt-Malan, Suzannah M., GreenwoodâQuaintance, Kerryl E. , Mandrekar, Jayawant N. , Lehoux, Dario , Schuch, Raymond , Cassino, Cara, Patel, Robin , Mandrekar, Jayawant, Schuch, Raymond , Patel, Robin , Yan, Qun
Antimicrobial Agents and Chemotherapy | July 30, 2019 | Volume: 63 | Issue: 10 | Pages: No page available
Bacteriophage-derived lysins are being developed as anti-infective agents. In an acute osteomyelitis methicillin-resistant Staphylococcus aureus (MRSA) model, rats receiving no treatment or treatment with daptomycin, exebacase (CF-301), or daptomycin plus exebacase had means of 5.13, 4.09, 4.65, and 3.57 log 10 CFU/gram of bone, respectively.