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Krieger, Stephen

0009-0000-8348-7923

Mayo Clinic

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Citations 1

Spinal cord imaging for multiple sclerosis: Advances, priorities, and opportunities
Laule, Cornelia , Cohen-Adad, Julien, Witt, Atlee , Luca, Gabriele C. De, Granziera, Cristina , Keegan, B. Mark , Kerbrat, Anne , Klawiter, Eric C, Kolind, Shannon , O’Grady, Kristin P. , Oh, Jiwon, Sivakolundu, Dinesh K. , Smith, Seth A, Vavasour, Irene M, Mainero, Caterina , Alonso-Ortiz, Eva, Krieger, Stephen , Li, David , Shinohara, Russell T, Henry, Roland G, Cooperative, North American Imaging in Multiple Sclerosis (NAIMS), Witt, Atlee A , De Luca, Gabriele C , Bagnato, Francesca R. , Gauthier, Susan A , Bakshi, Rohit , Beck, Erin S , Krieger, Stephen , Keegan, B Mark , Kollind, Shannon H , Granziera, Cristina , O'Grady, Kristin P , Cohen-Adad, Julien , DeLuca, Gabriele C. , Kerbrat, Anne , Klawiter, Eric C. , Oh, Jiwon , Schilling, Kurt G. , Smith, Seth A. , Tozlu, Ceren , Vavasour, Irene M. , Alonso‐Ortiz, Eva , Brier, Matthew R. , Hemond, Christopher C , Li, David K.B. , Shinohara, Russell Taki , Henry, Roland G.

Multiple Sclerosis Journal | June 1, 2026 | Volume: No volume available | Issue: No issue available | Pages: No page available

10.1177/13524585261444600 Get It

The spinal cord plays a central role in the pathophysiology and clinical manifestations of multiple sclerosis (MS), yet remains under-studied compared with the brain. This review summarizes key insights from the 2025 North American Imaging in MS Spinal Cord Imaging Workshop, highlighting recent advances, ongoing challenges, and future opportunities in MS spinal cord imaging. We review pathological studies and outline the clinical relevance of spinal cord lesions and atrophy for diagnosis, prognosis, and disease monitoring, highlighting emerging biomarkers of progression independent of relapse activity. Correlations between magnetic resonance imaging, histopathology, and clinical outcomes support the validation and translational potential of advanced spinal cord imaging techniques. Finally, we discuss spinal cord–specific processing pipelines and reproducibility challenges. Collectively, these insights underscore the need to integrate advanced and quantitative spinal cord imaging into clinical trials, research studies, and—when feasible—clinical care, to fully capture the extent of MS pathology, and ultimately improve patient outcomes.